SA4503, A Potent Sigma-1 Receptor Ligand, Ameliorates Synaptic Abnormalities and Cognitive Dysfunction in a Mouse Model of ATR-X Syndrome

α-thalassemia X-linked intellectual disability (ATR-X) syndrome is caused by mutations in ATRX. An ATR-X model mouse lacking Atrx exon 2 displays phenotypes that resemble symptoms in the human intellectual disability: cognitive defects and abnormal dendritic spine formation. We herein target activat...

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Detalles Bibliográficos
Autores principales: Yamaguchi, Kouya, Shioda, Norifumi, Yabuki, Yasushi, Zhang, Chen, Han, Feng, Fukunaga, Kohji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163584/
https://www.ncbi.nlm.nih.gov/pubmed/30231518
http://dx.doi.org/10.3390/ijms19092811

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