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Maternal Iodine Status is Associated with Offspring Language Skills in Infancy and Toddlerhood

Inadequate iodine status affects the synthesis of the thyroid hormones and may impair brain development in fetal life. The aim of this study was to explore the association between maternal iodine status in pregnancy measured by urinary iodine concentration (UIC) and child neurodevelopment at age 6,...

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Autores principales: Markhus, Maria Wik, Dahl, Lisbeth, Moe, Vibeke, Abel, Marianne Hope, Brantsæter, Anne Lise, Øyen, Jannike, Meltzer, Helle Margrete, Stormark, Kjell Morten, Graff, Ingvild Eide, Smith, Lars, Kjellevold, Marian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163597/
https://www.ncbi.nlm.nih.gov/pubmed/30205599
http://dx.doi.org/10.3390/nu10091270
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author Markhus, Maria Wik
Dahl, Lisbeth
Moe, Vibeke
Abel, Marianne Hope
Brantsæter, Anne Lise
Øyen, Jannike
Meltzer, Helle Margrete
Stormark, Kjell Morten
Graff, Ingvild Eide
Smith, Lars
Kjellevold, Marian
author_facet Markhus, Maria Wik
Dahl, Lisbeth
Moe, Vibeke
Abel, Marianne Hope
Brantsæter, Anne Lise
Øyen, Jannike
Meltzer, Helle Margrete
Stormark, Kjell Morten
Graff, Ingvild Eide
Smith, Lars
Kjellevold, Marian
author_sort Markhus, Maria Wik
collection PubMed
description Inadequate iodine status affects the synthesis of the thyroid hormones and may impair brain development in fetal life. The aim of this study was to explore the association between maternal iodine status in pregnancy measured by urinary iodine concentration (UIC) and child neurodevelopment at age 6, 12 and 18 months in a population-based cohort. In total, 1036 families from nine locations in Norway were enrolled in the little in Norway cohort. The present study includes n = 851 mother-child pairs with singleton pregnancies, no use of thyroid medication in pregnancy, no severe genetic disorder, data on exposure (UIC) in pregnancy and developmental outcomes (Bayley Scales of Infant and Toddler Development, third edition). Data collection also included general information from questionnaires. We examined associations between UIC (and use of iodine-containing supplements) and repeated measures of developmental outcomes using multivariable mixed models. The median UIC in pregnancy was 78 µg/L (IQR 46–130), classified as insufficient iodine intake according to the WHO. Eighteen percent reported use of iodine-containing multisupplements. A UIC below ~100 was associated with reduced receptive (p = 0.025) and expressive language skills (p = 0.002), but not with reduced cognitive or fine- and gross motor skills. Maternal use of iodine-containing supplements was associated with lower gross motor skills (b = −0.18, 95% CI = −0.33, −0.03, p = 0.02), but not with the other outcome measures. In conclusion, an insufficient iodine intake in pregnancy, reflected in a UIC below ~100 µg/L, was associated with lower infant language skills up to 18 months. The use of iodine-containing supplements was not associated with beneficial effects.
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spelling pubmed-61635972018-10-10 Maternal Iodine Status is Associated with Offspring Language Skills in Infancy and Toddlerhood Markhus, Maria Wik Dahl, Lisbeth Moe, Vibeke Abel, Marianne Hope Brantsæter, Anne Lise Øyen, Jannike Meltzer, Helle Margrete Stormark, Kjell Morten Graff, Ingvild Eide Smith, Lars Kjellevold, Marian Nutrients Article Inadequate iodine status affects the synthesis of the thyroid hormones and may impair brain development in fetal life. The aim of this study was to explore the association between maternal iodine status in pregnancy measured by urinary iodine concentration (UIC) and child neurodevelopment at age 6, 12 and 18 months in a population-based cohort. In total, 1036 families from nine locations in Norway were enrolled in the little in Norway cohort. The present study includes n = 851 mother-child pairs with singleton pregnancies, no use of thyroid medication in pregnancy, no severe genetic disorder, data on exposure (UIC) in pregnancy and developmental outcomes (Bayley Scales of Infant and Toddler Development, third edition). Data collection also included general information from questionnaires. We examined associations between UIC (and use of iodine-containing supplements) and repeated measures of developmental outcomes using multivariable mixed models. The median UIC in pregnancy was 78 µg/L (IQR 46–130), classified as insufficient iodine intake according to the WHO. Eighteen percent reported use of iodine-containing multisupplements. A UIC below ~100 was associated with reduced receptive (p = 0.025) and expressive language skills (p = 0.002), but not with reduced cognitive or fine- and gross motor skills. Maternal use of iodine-containing supplements was associated with lower gross motor skills (b = −0.18, 95% CI = −0.33, −0.03, p = 0.02), but not with the other outcome measures. In conclusion, an insufficient iodine intake in pregnancy, reflected in a UIC below ~100 µg/L, was associated with lower infant language skills up to 18 months. The use of iodine-containing supplements was not associated with beneficial effects. MDPI 2018-09-09 /pmc/articles/PMC6163597/ /pubmed/30205599 http://dx.doi.org/10.3390/nu10091270 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Markhus, Maria Wik
Dahl, Lisbeth
Moe, Vibeke
Abel, Marianne Hope
Brantsæter, Anne Lise
Øyen, Jannike
Meltzer, Helle Margrete
Stormark, Kjell Morten
Graff, Ingvild Eide
Smith, Lars
Kjellevold, Marian
Maternal Iodine Status is Associated with Offspring Language Skills in Infancy and Toddlerhood
title Maternal Iodine Status is Associated with Offspring Language Skills in Infancy and Toddlerhood
title_full Maternal Iodine Status is Associated with Offspring Language Skills in Infancy and Toddlerhood
title_fullStr Maternal Iodine Status is Associated with Offspring Language Skills in Infancy and Toddlerhood
title_full_unstemmed Maternal Iodine Status is Associated with Offspring Language Skills in Infancy and Toddlerhood
title_short Maternal Iodine Status is Associated with Offspring Language Skills in Infancy and Toddlerhood
title_sort maternal iodine status is associated with offspring language skills in infancy and toddlerhood
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163597/
https://www.ncbi.nlm.nih.gov/pubmed/30205599
http://dx.doi.org/10.3390/nu10091270
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