TOP2B: The First Thirty Years

Type II DNA topoisomerases (EC 5.99.1.3) are enzymes that catalyse topological changes in DNA in an ATP dependent manner. Strand passage reactions involve passing one double stranded DNA duplex (transported helix) through a transient enzyme-bridged break in another (gated helix). This activity is re...

Descripción completa

Detalles Bibliográficos
Autores principales: Austin, Caroline A., Lee, Ka C., Swan, Rebecca L., Khazeem, Mushtaq M., Manville, Catriona M., Cridland, Peter, Treumann, Achim, Porter, Andrew, Morris, Nick J., Cowell, Ian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163646/
https://www.ncbi.nlm.nih.gov/pubmed/30223465
http://dx.doi.org/10.3390/ijms19092765
_version_ 1783359411392086016
author Austin, Caroline A.
Lee, Ka C.
Swan, Rebecca L.
Khazeem, Mushtaq M.
Manville, Catriona M.
Cridland, Peter
Treumann, Achim
Porter, Andrew
Morris, Nick J.
Cowell, Ian G.
author_facet Austin, Caroline A.
Lee, Ka C.
Swan, Rebecca L.
Khazeem, Mushtaq M.
Manville, Catriona M.
Cridland, Peter
Treumann, Achim
Porter, Andrew
Morris, Nick J.
Cowell, Ian G.
author_sort Austin, Caroline A.
collection PubMed
description Type II DNA topoisomerases (EC 5.99.1.3) are enzymes that catalyse topological changes in DNA in an ATP dependent manner. Strand passage reactions involve passing one double stranded DNA duplex (transported helix) through a transient enzyme-bridged break in another (gated helix). This activity is required for a range of cellular processes including transcription. Vertebrates have two isoforms: topoisomerase IIα and β. Topoisomerase IIβ was first reported in 1987. Here we review the research on DNA topoisomerase IIβ over the 30 years since its discovery.
format Online
Article
Text
id pubmed-6163646
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-61636462018-10-10 TOP2B: The First Thirty Years Austin, Caroline A. Lee, Ka C. Swan, Rebecca L. Khazeem, Mushtaq M. Manville, Catriona M. Cridland, Peter Treumann, Achim Porter, Andrew Morris, Nick J. Cowell, Ian G. Int J Mol Sci Review Type II DNA topoisomerases (EC 5.99.1.3) are enzymes that catalyse topological changes in DNA in an ATP dependent manner. Strand passage reactions involve passing one double stranded DNA duplex (transported helix) through a transient enzyme-bridged break in another (gated helix). This activity is required for a range of cellular processes including transcription. Vertebrates have two isoforms: topoisomerase IIα and β. Topoisomerase IIβ was first reported in 1987. Here we review the research on DNA topoisomerase IIβ over the 30 years since its discovery. MDPI 2018-09-14 /pmc/articles/PMC6163646/ /pubmed/30223465 http://dx.doi.org/10.3390/ijms19092765 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Austin, Caroline A.
Lee, Ka C.
Swan, Rebecca L.
Khazeem, Mushtaq M.
Manville, Catriona M.
Cridland, Peter
Treumann, Achim
Porter, Andrew
Morris, Nick J.
Cowell, Ian G.
TOP2B: The First Thirty Years
title TOP2B: The First Thirty Years
title_full TOP2B: The First Thirty Years
title_fullStr TOP2B: The First Thirty Years
title_full_unstemmed TOP2B: The First Thirty Years
title_short TOP2B: The First Thirty Years
title_sort top2b: the first thirty years
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163646/
https://www.ncbi.nlm.nih.gov/pubmed/30223465
http://dx.doi.org/10.3390/ijms19092765
work_keys_str_mv AT austincarolinea top2bthefirstthirtyyears
AT leekac top2bthefirstthirtyyears
AT swanrebeccal top2bthefirstthirtyyears
AT khazeemmushtaqm top2bthefirstthirtyyears
AT manvillecatrionam top2bthefirstthirtyyears
AT cridlandpeter top2bthefirstthirtyyears
AT treumannachim top2bthefirstthirtyyears
AT porterandrew top2bthefirstthirtyyears
AT morrisnickj top2bthefirstthirtyyears
AT cowelliang top2bthefirstthirtyyears

Ejemplares similares