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White-Tailed Sea Eagle (Haliaeetus albicilla) Die-Off Due to Infection with Highly Pathogenic Avian Influenza Virus, Subtype H5N8, in Germany

In contrast to previous incursions of highly pathogenic avian influenza (HPAIV) H5 viruses, H5N8 clade 2.3.4.4b viruses caused numerous cases of lethal infections in white-tailed sea eagles (Haliaeetus albicilla) affecting mainly young eagles (younger than five years of age) in Germany during winter...

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Autores principales: Krone, Oliver, Globig, Anja, Ulrich, Reiner, Harder, Timm, Schinköthe, Jan, Herrmann, Christof, Gerst, Sascha, Conraths, Franz J., Beer, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163648/
https://www.ncbi.nlm.nih.gov/pubmed/30205456
http://dx.doi.org/10.3390/v10090478
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author Krone, Oliver
Globig, Anja
Ulrich, Reiner
Harder, Timm
Schinköthe, Jan
Herrmann, Christof
Gerst, Sascha
Conraths, Franz J.
Beer, Martin
author_facet Krone, Oliver
Globig, Anja
Ulrich, Reiner
Harder, Timm
Schinköthe, Jan
Herrmann, Christof
Gerst, Sascha
Conraths, Franz J.
Beer, Martin
author_sort Krone, Oliver
collection PubMed
description In contrast to previous incursions of highly pathogenic avian influenza (HPAIV) H5 viruses, H5N8 clade 2.3.4.4b viruses caused numerous cases of lethal infections in white-tailed sea eagles (Haliaeetus albicilla) affecting mainly young eagles (younger than five years of age) in Germany during winter 2016/2017. Until April 2017, 17 HPAIV H5N8-positive white-tailed sea eagles had been detected (three found alive and 14 carcasses) by real-time RT-PCR and partial nucleotide sequence analyses. Severe neurological clinical signs were noticed which were corroborated by immunohistopathology revealing mild to moderate, oligo- to multifocal necrotizing virus-induced polioencephalitis. Lethal lead (Pb) concentrations, a main factor of mortality in sea eagles in previous years, could be ruled out by atomic absorption spectrometry. HPAIV H5 clade 2.3.4.4b reportedly is the first highly pathogenic influenza virus known to induce fatal disease in European white-tailed see eagles. This virus strain may become a new health threat to a highly protected species across its distribution range in Eurasia. Positive cloacal swabs suggest that eagles can spread the virus with their faeces.
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spelling pubmed-61636482018-10-11 White-Tailed Sea Eagle (Haliaeetus albicilla) Die-Off Due to Infection with Highly Pathogenic Avian Influenza Virus, Subtype H5N8, in Germany Krone, Oliver Globig, Anja Ulrich, Reiner Harder, Timm Schinköthe, Jan Herrmann, Christof Gerst, Sascha Conraths, Franz J. Beer, Martin Viruses Communication In contrast to previous incursions of highly pathogenic avian influenza (HPAIV) H5 viruses, H5N8 clade 2.3.4.4b viruses caused numerous cases of lethal infections in white-tailed sea eagles (Haliaeetus albicilla) affecting mainly young eagles (younger than five years of age) in Germany during winter 2016/2017. Until April 2017, 17 HPAIV H5N8-positive white-tailed sea eagles had been detected (three found alive and 14 carcasses) by real-time RT-PCR and partial nucleotide sequence analyses. Severe neurological clinical signs were noticed which were corroborated by immunohistopathology revealing mild to moderate, oligo- to multifocal necrotizing virus-induced polioencephalitis. Lethal lead (Pb) concentrations, a main factor of mortality in sea eagles in previous years, could be ruled out by atomic absorption spectrometry. HPAIV H5 clade 2.3.4.4b reportedly is the first highly pathogenic influenza virus known to induce fatal disease in European white-tailed see eagles. This virus strain may become a new health threat to a highly protected species across its distribution range in Eurasia. Positive cloacal swabs suggest that eagles can spread the virus with their faeces. MDPI 2018-09-07 /pmc/articles/PMC6163648/ /pubmed/30205456 http://dx.doi.org/10.3390/v10090478 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Krone, Oliver
Globig, Anja
Ulrich, Reiner
Harder, Timm
Schinköthe, Jan
Herrmann, Christof
Gerst, Sascha
Conraths, Franz J.
Beer, Martin
White-Tailed Sea Eagle (Haliaeetus albicilla) Die-Off Due to Infection with Highly Pathogenic Avian Influenza Virus, Subtype H5N8, in Germany
title White-Tailed Sea Eagle (Haliaeetus albicilla) Die-Off Due to Infection with Highly Pathogenic Avian Influenza Virus, Subtype H5N8, in Germany
title_full White-Tailed Sea Eagle (Haliaeetus albicilla) Die-Off Due to Infection with Highly Pathogenic Avian Influenza Virus, Subtype H5N8, in Germany
title_fullStr White-Tailed Sea Eagle (Haliaeetus albicilla) Die-Off Due to Infection with Highly Pathogenic Avian Influenza Virus, Subtype H5N8, in Germany
title_full_unstemmed White-Tailed Sea Eagle (Haliaeetus albicilla) Die-Off Due to Infection with Highly Pathogenic Avian Influenza Virus, Subtype H5N8, in Germany
title_short White-Tailed Sea Eagle (Haliaeetus albicilla) Die-Off Due to Infection with Highly Pathogenic Avian Influenza Virus, Subtype H5N8, in Germany
title_sort white-tailed sea eagle (haliaeetus albicilla) die-off due to infection with highly pathogenic avian influenza virus, subtype h5n8, in germany
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163648/
https://www.ncbi.nlm.nih.gov/pubmed/30205456
http://dx.doi.org/10.3390/v10090478
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