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Widespread Expression of Hedgehog Pathway Components in a Large Panel of Human Tumor Cells and Inhibition of Tumor Growth by GANT61: Implications for Cancer Therapy

The sonic Hedgehog/GLI signaling pathway (HH) is critical for maintaining tissue polarity in development and contributes to tumor stemness. Transcription factors GLI1–3 are the downstream effectors of HH and activate oncogenic targets. To explore the completeness of the expression of HH components i...

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Detalles Bibliográficos
Autores principales:	Réda, Jiri, Vachtenheim, Jiri, Vlčková, Kateřina, Horák, Pavel, Ondrušová, Lubica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163708/ https://www.ncbi.nlm.nih.gov/pubmed/30201866 http://dx.doi.org/10.3390/ijms19092682

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