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Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology

The endometrium is an accessible source of mesenchymal stem cells. Most investigations of endometrial mesenchymal stem cells (eMSCs) have been conducted in humans. In animals, particularly in livestock, eMSC research is scarce. Such cells have been described in the bovine, ovine, caprine, porcine, a...

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Autores principales: Lara, Evelyn, Rivera, Nathaly, Cabezas, Joel, Navarrete, Felipe, Saravia, Fernando, Rodríguez-Alvarez, Lleretny, Castro, Fidel Ovidio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163755/
https://www.ncbi.nlm.nih.gov/pubmed/30231577
http://dx.doi.org/10.3390/bioengineering5030075
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author Lara, Evelyn
Rivera, Nathaly
Cabezas, Joel
Navarrete, Felipe
Saravia, Fernando
Rodríguez-Alvarez, Lleretny
Castro, Fidel Ovidio
author_facet Lara, Evelyn
Rivera, Nathaly
Cabezas, Joel
Navarrete, Felipe
Saravia, Fernando
Rodríguez-Alvarez, Lleretny
Castro, Fidel Ovidio
author_sort Lara, Evelyn
collection PubMed
description The endometrium is an accessible source of mesenchymal stem cells. Most investigations of endometrial mesenchymal stem cells (eMSCs) have been conducted in humans. In animals, particularly in livestock, eMSC research is scarce. Such cells have been described in the bovine, ovine, caprine, porcine, and equine endometrium. Here we provide the state of the art of eMSCs in farm animals with a focus on the bovine species. In bovines, eMSCs have been identified during the phases of the estrous cycle, during which their functionality and the presence of eMSC-specific markers has been shown to change. Moreover, postpartum inflammation related to endometritis affects the presence and functionality of eMSCs, and prostaglandin E(2) (PGE(2)) may be the mediator of such changes. We demonstrated that exposure to PGE(2) in vitro modifies the transcriptomic profile of eMSCs, showing its potential role in the fate of stem cell activation, migration, and homing during pathological uterine inflammation in endometritis and in healthy puerperal endometrium. Farm animal research on eMSCs can be of great value in translational research for certain uterine pathologies and for immunomodulation of local responses to pathogens, hormones, and other substances. Further research is necessary in areas such as in vivo location of the niches and their immunomodulatory and anti-infective properties.
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spelling pubmed-61637552018-10-11 Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology Lara, Evelyn Rivera, Nathaly Cabezas, Joel Navarrete, Felipe Saravia, Fernando Rodríguez-Alvarez, Lleretny Castro, Fidel Ovidio Bioengineering (Basel) Review The endometrium is an accessible source of mesenchymal stem cells. Most investigations of endometrial mesenchymal stem cells (eMSCs) have been conducted in humans. In animals, particularly in livestock, eMSC research is scarce. Such cells have been described in the bovine, ovine, caprine, porcine, and equine endometrium. Here we provide the state of the art of eMSCs in farm animals with a focus on the bovine species. In bovines, eMSCs have been identified during the phases of the estrous cycle, during which their functionality and the presence of eMSC-specific markers has been shown to change. Moreover, postpartum inflammation related to endometritis affects the presence and functionality of eMSCs, and prostaglandin E(2) (PGE(2)) may be the mediator of such changes. We demonstrated that exposure to PGE(2) in vitro modifies the transcriptomic profile of eMSCs, showing its potential role in the fate of stem cell activation, migration, and homing during pathological uterine inflammation in endometritis and in healthy puerperal endometrium. Farm animal research on eMSCs can be of great value in translational research for certain uterine pathologies and for immunomodulation of local responses to pathogens, hormones, and other substances. Further research is necessary in areas such as in vivo location of the niches and their immunomodulatory and anti-infective properties. MDPI 2018-09-18 /pmc/articles/PMC6163755/ /pubmed/30231577 http://dx.doi.org/10.3390/bioengineering5030075 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lara, Evelyn
Rivera, Nathaly
Cabezas, Joel
Navarrete, Felipe
Saravia, Fernando
Rodríguez-Alvarez, Lleretny
Castro, Fidel Ovidio
Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology
title Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology
title_full Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology
title_fullStr Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology
title_full_unstemmed Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology
title_short Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology
title_sort endometrial stem cells in farm animals: potential role in uterine physiology and pathology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163755/
https://www.ncbi.nlm.nih.gov/pubmed/30231577
http://dx.doi.org/10.3390/bioengineering5030075
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