Cargando…
Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology
The endometrium is an accessible source of mesenchymal stem cells. Most investigations of endometrial mesenchymal stem cells (eMSCs) have been conducted in humans. In animals, particularly in livestock, eMSC research is scarce. Such cells have been described in the bovine, ovine, caprine, porcine, a...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163755/ https://www.ncbi.nlm.nih.gov/pubmed/30231577 http://dx.doi.org/10.3390/bioengineering5030075 |
_version_ | 1783359437478559744 |
---|---|
author | Lara, Evelyn Rivera, Nathaly Cabezas, Joel Navarrete, Felipe Saravia, Fernando Rodríguez-Alvarez, Lleretny Castro, Fidel Ovidio |
author_facet | Lara, Evelyn Rivera, Nathaly Cabezas, Joel Navarrete, Felipe Saravia, Fernando Rodríguez-Alvarez, Lleretny Castro, Fidel Ovidio |
author_sort | Lara, Evelyn |
collection | PubMed |
description | The endometrium is an accessible source of mesenchymal stem cells. Most investigations of endometrial mesenchymal stem cells (eMSCs) have been conducted in humans. In animals, particularly in livestock, eMSC research is scarce. Such cells have been described in the bovine, ovine, caprine, porcine, and equine endometrium. Here we provide the state of the art of eMSCs in farm animals with a focus on the bovine species. In bovines, eMSCs have been identified during the phases of the estrous cycle, during which their functionality and the presence of eMSC-specific markers has been shown to change. Moreover, postpartum inflammation related to endometritis affects the presence and functionality of eMSCs, and prostaglandin E(2) (PGE(2)) may be the mediator of such changes. We demonstrated that exposure to PGE(2) in vitro modifies the transcriptomic profile of eMSCs, showing its potential role in the fate of stem cell activation, migration, and homing during pathological uterine inflammation in endometritis and in healthy puerperal endometrium. Farm animal research on eMSCs can be of great value in translational research for certain uterine pathologies and for immunomodulation of local responses to pathogens, hormones, and other substances. Further research is necessary in areas such as in vivo location of the niches and their immunomodulatory and anti-infective properties. |
format | Online Article Text |
id | pubmed-6163755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61637552018-10-11 Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology Lara, Evelyn Rivera, Nathaly Cabezas, Joel Navarrete, Felipe Saravia, Fernando Rodríguez-Alvarez, Lleretny Castro, Fidel Ovidio Bioengineering (Basel) Review The endometrium is an accessible source of mesenchymal stem cells. Most investigations of endometrial mesenchymal stem cells (eMSCs) have been conducted in humans. In animals, particularly in livestock, eMSC research is scarce. Such cells have been described in the bovine, ovine, caprine, porcine, and equine endometrium. Here we provide the state of the art of eMSCs in farm animals with a focus on the bovine species. In bovines, eMSCs have been identified during the phases of the estrous cycle, during which their functionality and the presence of eMSC-specific markers has been shown to change. Moreover, postpartum inflammation related to endometritis affects the presence and functionality of eMSCs, and prostaglandin E(2) (PGE(2)) may be the mediator of such changes. We demonstrated that exposure to PGE(2) in vitro modifies the transcriptomic profile of eMSCs, showing its potential role in the fate of stem cell activation, migration, and homing during pathological uterine inflammation in endometritis and in healthy puerperal endometrium. Farm animal research on eMSCs can be of great value in translational research for certain uterine pathologies and for immunomodulation of local responses to pathogens, hormones, and other substances. Further research is necessary in areas such as in vivo location of the niches and their immunomodulatory and anti-infective properties. MDPI 2018-09-18 /pmc/articles/PMC6163755/ /pubmed/30231577 http://dx.doi.org/10.3390/bioengineering5030075 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lara, Evelyn Rivera, Nathaly Cabezas, Joel Navarrete, Felipe Saravia, Fernando Rodríguez-Alvarez, Lleretny Castro, Fidel Ovidio Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology |
title | Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology |
title_full | Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology |
title_fullStr | Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology |
title_full_unstemmed | Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology |
title_short | Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology |
title_sort | endometrial stem cells in farm animals: potential role in uterine physiology and pathology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163755/ https://www.ncbi.nlm.nih.gov/pubmed/30231577 http://dx.doi.org/10.3390/bioengineering5030075 |
work_keys_str_mv | AT laraevelyn endometrialstemcellsinfarmanimalspotentialroleinuterinephysiologyandpathology AT riveranathaly endometrialstemcellsinfarmanimalspotentialroleinuterinephysiologyandpathology AT cabezasjoel endometrialstemcellsinfarmanimalspotentialroleinuterinephysiologyandpathology AT navarretefelipe endometrialstemcellsinfarmanimalspotentialroleinuterinephysiologyandpathology AT saraviafernando endometrialstemcellsinfarmanimalspotentialroleinuterinephysiologyandpathology AT rodriguezalvarezlleretny endometrialstemcellsinfarmanimalspotentialroleinuterinephysiologyandpathology AT castrofidelovidio endometrialstemcellsinfarmanimalspotentialroleinuterinephysiologyandpathology |