Cargando…

Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial

Ketogenic diets (KDs) are gaining attention as a potential adjuvant therapy for cancer, but data are limited for KDs’ effects on quality of life. We hypothesized that the KD would (1) improve mental and physical function, including energy levels, (2) reduce hunger, and (3) diminish sweet and starchy...

Descripción completa

Detalles Bibliográficos
Autores principales: Cohen, Caroline W., Fontaine, Kevin R., Arend, Rebecca C., Soleymani, Taraneh, Gower, Barbara A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163837/
https://www.ncbi.nlm.nih.gov/pubmed/30200193
http://dx.doi.org/10.3390/nu10091187
_version_ 1783359457200177152
author Cohen, Caroline W.
Fontaine, Kevin R.
Arend, Rebecca C.
Soleymani, Taraneh
Gower, Barbara A.
author_facet Cohen, Caroline W.
Fontaine, Kevin R.
Arend, Rebecca C.
Soleymani, Taraneh
Gower, Barbara A.
author_sort Cohen, Caroline W.
collection PubMed
description Ketogenic diets (KDs) are gaining attention as a potential adjuvant therapy for cancer, but data are limited for KDs’ effects on quality of life. We hypothesized that the KD would (1) improve mental and physical function, including energy levels, (2) reduce hunger, and (3) diminish sweet and starchy food cravings in women with ovarian or endometrial cancer. Participants were randomized to a KD (70:25:5 energy from fat, protein, and carbohydrate) or the American Cancer Society diet (ACS: high-fiber, lower-fat). Questionnaires were administered at baseline and after 12 weeks on the assigned diet to assess changes in mental and physical health, perceived energy, appetite, and food cravings. We assessed both between-group differences and within-group changes using ANCOVA and paired t-tests, respectively. After 12 weeks, there was a significant between-group difference in adjusted physical function scores (p < 0.05), and KD participants not receiving chemotherapy reported a significant within-group reduction in fatigue (p < 0.05). There were no significant between-group differences in mental function, hunger, or appetite. There was a significant between-group difference in adjusted cravings for starchy foods and fast food fats at 12 weeks (p < 0.05 for both), with the KD group demonstrating less frequent cravings than the ACS. In conclusion, in women with ovarian or endometrial cancer, a KD does not negatively affect quality of life and in fact may improve physical function, increase energy, and diminish specific food cravings. This trial was registered at ClinicalTrials.gov as NCT03171506.
format Online
Article
Text
id pubmed-6163837
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-61638372018-10-10 Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial Cohen, Caroline W. Fontaine, Kevin R. Arend, Rebecca C. Soleymani, Taraneh Gower, Barbara A. Nutrients Article Ketogenic diets (KDs) are gaining attention as a potential adjuvant therapy for cancer, but data are limited for KDs’ effects on quality of life. We hypothesized that the KD would (1) improve mental and physical function, including energy levels, (2) reduce hunger, and (3) diminish sweet and starchy food cravings in women with ovarian or endometrial cancer. Participants were randomized to a KD (70:25:5 energy from fat, protein, and carbohydrate) or the American Cancer Society diet (ACS: high-fiber, lower-fat). Questionnaires were administered at baseline and after 12 weeks on the assigned diet to assess changes in mental and physical health, perceived energy, appetite, and food cravings. We assessed both between-group differences and within-group changes using ANCOVA and paired t-tests, respectively. After 12 weeks, there was a significant between-group difference in adjusted physical function scores (p < 0.05), and KD participants not receiving chemotherapy reported a significant within-group reduction in fatigue (p < 0.05). There were no significant between-group differences in mental function, hunger, or appetite. There was a significant between-group difference in adjusted cravings for starchy foods and fast food fats at 12 weeks (p < 0.05 for both), with the KD group demonstrating less frequent cravings than the ACS. In conclusion, in women with ovarian or endometrial cancer, a KD does not negatively affect quality of life and in fact may improve physical function, increase energy, and diminish specific food cravings. This trial was registered at ClinicalTrials.gov as NCT03171506. MDPI 2018-08-30 /pmc/articles/PMC6163837/ /pubmed/30200193 http://dx.doi.org/10.3390/nu10091187 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cohen, Caroline W.
Fontaine, Kevin R.
Arend, Rebecca C.
Soleymani, Taraneh
Gower, Barbara A.
Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial
title Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial
title_full Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial
title_fullStr Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial
title_full_unstemmed Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial
title_short Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial
title_sort favorable effects of a ketogenic diet on physical function, perceived energy, and food cravings in women with ovarian or endometrial cancer: a randomized, controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163837/
https://www.ncbi.nlm.nih.gov/pubmed/30200193
http://dx.doi.org/10.3390/nu10091187
work_keys_str_mv AT cohencarolinew favorableeffectsofaketogenicdietonphysicalfunctionperceivedenergyandfoodcravingsinwomenwithovarianorendometrialcancerarandomizedcontrolledtrial
AT fontainekevinr favorableeffectsofaketogenicdietonphysicalfunctionperceivedenergyandfoodcravingsinwomenwithovarianorendometrialcancerarandomizedcontrolledtrial
AT arendrebeccac favorableeffectsofaketogenicdietonphysicalfunctionperceivedenergyandfoodcravingsinwomenwithovarianorendometrialcancerarandomizedcontrolledtrial
AT soleymanitaraneh favorableeffectsofaketogenicdietonphysicalfunctionperceivedenergyandfoodcravingsinwomenwithovarianorendometrialcancerarandomizedcontrolledtrial
AT gowerbarbaraa favorableeffectsofaketogenicdietonphysicalfunctionperceivedenergyandfoodcravingsinwomenwithovarianorendometrialcancerarandomizedcontrolledtrial