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A Comparison of Vitamin E Status and Associated Pregnancy Outcomes in Maternal–Infant Dyads between a Nigerian and a United States Population
Oxidative stress is associated with adverse pregnancy outcomes, and vitamin E has powerful anti-oxidant properties with the potential to impact health outcomes. Tocopherol isomers of vitamin E differ in their ability to modulate inflammation and vary in concentration in diets containing high proport...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163868/ https://www.ncbi.nlm.nih.gov/pubmed/30223433 http://dx.doi.org/10.3390/nu10091300 |
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author | Cave, Caleb Hanson, Corrine Schumacher, Marina Lyden, Elizabeth Furtado, Jeremy Obaro, Stephen Delair, Shirley Kocmich, Nicholas Rezac, Amy Izevbigie, NI Van Ormer, Matthew Kamil, Ammar McGinn, Elizabeth Rilett, Katherine Elliott, Elizabeth Johnson, Rebecca Weishaar, Kara Olateju, EK Akaba, GA Anigilaje, EA Tahiru, Tahiru Anderson-Berry, Ann |
author_facet | Cave, Caleb Hanson, Corrine Schumacher, Marina Lyden, Elizabeth Furtado, Jeremy Obaro, Stephen Delair, Shirley Kocmich, Nicholas Rezac, Amy Izevbigie, NI Van Ormer, Matthew Kamil, Ammar McGinn, Elizabeth Rilett, Katherine Elliott, Elizabeth Johnson, Rebecca Weishaar, Kara Olateju, EK Akaba, GA Anigilaje, EA Tahiru, Tahiru Anderson-Berry, Ann |
author_sort | Cave, Caleb |
collection | PubMed |
description | Oxidative stress is associated with adverse pregnancy outcomes, and vitamin E has powerful anti-oxidant properties with the potential to impact health outcomes. Tocopherol isomers of vitamin E differ in their ability to modulate inflammation and vary in concentration in diets containing high proportions of processed versus unprocessed foods. The purpose of this study was to compare vitamin E status and associated pregnancy outcomes (mode of delivery, chorioamnionitis, APGARs (measure of appearance, pulse, grimace, activity, respiration), gestational age at delivery, and fetal growth) between maternal–infant dyads in a developed and a developing nation to identify potentially modifiable differences that may impact pregnancy and neonatal outcomes and provide a way to improve maternal and neonatal health. Plasma tocopherol levels were evaluated in 189 Midwestern United States (US) mother–infant pairs and 99 Central Nigerian mother–infant pairs. Maternal and infant concentrations of α-, γ-, and δ-tocopherol were measured using HPLC with diode-array detection. Descriptive statistics were calculated and tocopherol concentrations were associated with clinical outcomes such as mode of delivery, chorioamnionitis, APGARS, and fetal growth. Alpha- and γ-tocopherol levels were higher in the US mothers, (alpha: 12,357.9 (175.23–34,687.75) vs. 8333.1 (1576.59–16,248.40) (mcg/L); p < 0.001) (gamma: 340.7 (224.59–4385.95) vs. 357.5 (66.36–1775.31) (mcg/L); p < 0.001), while δ-tocopherol levels were higher in the Nigerian mothers (delta: 261.7 (24.70–1324.71) vs. 368.9 (43.06–1886.47) (mcg/L); p < 0.001). US infants had higher γ-tocopherol levels than Nigerian infants (203.1 (42.53–1953.23) vs. 113.8 (0.00–823.00) (mcg/L); p < 0.001), while both the Nigerian mothers and infants had higher α:γ-tocopherol ratios (8.5 vs. 26.2, and 8.9 vs. 18.8, respectively; p < 0.001). Our results in both populations show associations between increased circulating γ-tocopherol and negative outcomes like Caesarian sections, in contrast to the associations with positive outcomes such as vaginal delivery seen with increased α:γ-tocopherol ratios. Growth was positively associated with α- and γ-tocopherols in cord blood in the US population, and with cord blood δ-tocopherols in the Nigerian population. Tocopherol levels likely impact health outcomes in pregnancy in a complicated metabolism across the maternal–fetal axis that appears to be potentially influenced by culture and available diet. |
format | Online Article Text |
id | pubmed-6163868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61638682018-10-10 A Comparison of Vitamin E Status and Associated Pregnancy Outcomes in Maternal–Infant Dyads between a Nigerian and a United States Population Cave, Caleb Hanson, Corrine Schumacher, Marina Lyden, Elizabeth Furtado, Jeremy Obaro, Stephen Delair, Shirley Kocmich, Nicholas Rezac, Amy Izevbigie, NI Van Ormer, Matthew Kamil, Ammar McGinn, Elizabeth Rilett, Katherine Elliott, Elizabeth Johnson, Rebecca Weishaar, Kara Olateju, EK Akaba, GA Anigilaje, EA Tahiru, Tahiru Anderson-Berry, Ann Nutrients Article Oxidative stress is associated with adverse pregnancy outcomes, and vitamin E has powerful anti-oxidant properties with the potential to impact health outcomes. Tocopherol isomers of vitamin E differ in their ability to modulate inflammation and vary in concentration in diets containing high proportions of processed versus unprocessed foods. The purpose of this study was to compare vitamin E status and associated pregnancy outcomes (mode of delivery, chorioamnionitis, APGARs (measure of appearance, pulse, grimace, activity, respiration), gestational age at delivery, and fetal growth) between maternal–infant dyads in a developed and a developing nation to identify potentially modifiable differences that may impact pregnancy and neonatal outcomes and provide a way to improve maternal and neonatal health. Plasma tocopherol levels were evaluated in 189 Midwestern United States (US) mother–infant pairs and 99 Central Nigerian mother–infant pairs. Maternal and infant concentrations of α-, γ-, and δ-tocopherol were measured using HPLC with diode-array detection. Descriptive statistics were calculated and tocopherol concentrations were associated with clinical outcomes such as mode of delivery, chorioamnionitis, APGARS, and fetal growth. Alpha- and γ-tocopherol levels were higher in the US mothers, (alpha: 12,357.9 (175.23–34,687.75) vs. 8333.1 (1576.59–16,248.40) (mcg/L); p < 0.001) (gamma: 340.7 (224.59–4385.95) vs. 357.5 (66.36–1775.31) (mcg/L); p < 0.001), while δ-tocopherol levels were higher in the Nigerian mothers (delta: 261.7 (24.70–1324.71) vs. 368.9 (43.06–1886.47) (mcg/L); p < 0.001). US infants had higher γ-tocopherol levels than Nigerian infants (203.1 (42.53–1953.23) vs. 113.8 (0.00–823.00) (mcg/L); p < 0.001), while both the Nigerian mothers and infants had higher α:γ-tocopherol ratios (8.5 vs. 26.2, and 8.9 vs. 18.8, respectively; p < 0.001). Our results in both populations show associations between increased circulating γ-tocopherol and negative outcomes like Caesarian sections, in contrast to the associations with positive outcomes such as vaginal delivery seen with increased α:γ-tocopherol ratios. Growth was positively associated with α- and γ-tocopherols in cord blood in the US population, and with cord blood δ-tocopherols in the Nigerian population. Tocopherol levels likely impact health outcomes in pregnancy in a complicated metabolism across the maternal–fetal axis that appears to be potentially influenced by culture and available diet. MDPI 2018-09-14 /pmc/articles/PMC6163868/ /pubmed/30223433 http://dx.doi.org/10.3390/nu10091300 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cave, Caleb Hanson, Corrine Schumacher, Marina Lyden, Elizabeth Furtado, Jeremy Obaro, Stephen Delair, Shirley Kocmich, Nicholas Rezac, Amy Izevbigie, NI Van Ormer, Matthew Kamil, Ammar McGinn, Elizabeth Rilett, Katherine Elliott, Elizabeth Johnson, Rebecca Weishaar, Kara Olateju, EK Akaba, GA Anigilaje, EA Tahiru, Tahiru Anderson-Berry, Ann A Comparison of Vitamin E Status and Associated Pregnancy Outcomes in Maternal–Infant Dyads between a Nigerian and a United States Population |
title | A Comparison of Vitamin E Status and Associated Pregnancy Outcomes in Maternal–Infant Dyads between a Nigerian and a United States Population |
title_full | A Comparison of Vitamin E Status and Associated Pregnancy Outcomes in Maternal–Infant Dyads between a Nigerian and a United States Population |
title_fullStr | A Comparison of Vitamin E Status and Associated Pregnancy Outcomes in Maternal–Infant Dyads between a Nigerian and a United States Population |
title_full_unstemmed | A Comparison of Vitamin E Status and Associated Pregnancy Outcomes in Maternal–Infant Dyads between a Nigerian and a United States Population |
title_short | A Comparison of Vitamin E Status and Associated Pregnancy Outcomes in Maternal–Infant Dyads between a Nigerian and a United States Population |
title_sort | comparison of vitamin e status and associated pregnancy outcomes in maternal–infant dyads between a nigerian and a united states population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163868/ https://www.ncbi.nlm.nih.gov/pubmed/30223433 http://dx.doi.org/10.3390/nu10091300 |
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