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A Comparison of Vitamin E Status and Associated Pregnancy Outcomes in Maternal–Infant Dyads between a Nigerian and a United States Population

Oxidative stress is associated with adverse pregnancy outcomes, and vitamin E has powerful anti-oxidant properties with the potential to impact health outcomes. Tocopherol isomers of vitamin E differ in their ability to modulate inflammation and vary in concentration in diets containing high proport...

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Autores principales: Cave, Caleb, Hanson, Corrine, Schumacher, Marina, Lyden, Elizabeth, Furtado, Jeremy, Obaro, Stephen, Delair, Shirley, Kocmich, Nicholas, Rezac, Amy, Izevbigie, NI, Van Ormer, Matthew, Kamil, Ammar, McGinn, Elizabeth, Rilett, Katherine, Elliott, Elizabeth, Johnson, Rebecca, Weishaar, Kara, Olateju, EK, Akaba, GA, Anigilaje, EA, Tahiru, Tahiru, Anderson-Berry, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163868/
https://www.ncbi.nlm.nih.gov/pubmed/30223433
http://dx.doi.org/10.3390/nu10091300
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author Cave, Caleb
Hanson, Corrine
Schumacher, Marina
Lyden, Elizabeth
Furtado, Jeremy
Obaro, Stephen
Delair, Shirley
Kocmich, Nicholas
Rezac, Amy
Izevbigie, NI
Van Ormer, Matthew
Kamil, Ammar
McGinn, Elizabeth
Rilett, Katherine
Elliott, Elizabeth
Johnson, Rebecca
Weishaar, Kara
Olateju, EK
Akaba, GA
Anigilaje, EA
Tahiru, Tahiru
Anderson-Berry, Ann
author_facet Cave, Caleb
Hanson, Corrine
Schumacher, Marina
Lyden, Elizabeth
Furtado, Jeremy
Obaro, Stephen
Delair, Shirley
Kocmich, Nicholas
Rezac, Amy
Izevbigie, NI
Van Ormer, Matthew
Kamil, Ammar
McGinn, Elizabeth
Rilett, Katherine
Elliott, Elizabeth
Johnson, Rebecca
Weishaar, Kara
Olateju, EK
Akaba, GA
Anigilaje, EA
Tahiru, Tahiru
Anderson-Berry, Ann
author_sort Cave, Caleb
collection PubMed
description Oxidative stress is associated with adverse pregnancy outcomes, and vitamin E has powerful anti-oxidant properties with the potential to impact health outcomes. Tocopherol isomers of vitamin E differ in their ability to modulate inflammation and vary in concentration in diets containing high proportions of processed versus unprocessed foods. The purpose of this study was to compare vitamin E status and associated pregnancy outcomes (mode of delivery, chorioamnionitis, APGARs (measure of appearance, pulse, grimace, activity, respiration), gestational age at delivery, and fetal growth) between maternal–infant dyads in a developed and a developing nation to identify potentially modifiable differences that may impact pregnancy and neonatal outcomes and provide a way to improve maternal and neonatal health. Plasma tocopherol levels were evaluated in 189 Midwestern United States (US) mother–infant pairs and 99 Central Nigerian mother–infant pairs. Maternal and infant concentrations of α-, γ-, and δ-tocopherol were measured using HPLC with diode-array detection. Descriptive statistics were calculated and tocopherol concentrations were associated with clinical outcomes such as mode of delivery, chorioamnionitis, APGARS, and fetal growth. Alpha- and γ-tocopherol levels were higher in the US mothers, (alpha: 12,357.9 (175.23–34,687.75) vs. 8333.1 (1576.59–16,248.40) (mcg/L); p < 0.001) (gamma: 340.7 (224.59–4385.95) vs. 357.5 (66.36–1775.31) (mcg/L); p < 0.001), while δ-tocopherol levels were higher in the Nigerian mothers (delta: 261.7 (24.70–1324.71) vs. 368.9 (43.06–1886.47) (mcg/L); p < 0.001). US infants had higher γ-tocopherol levels than Nigerian infants (203.1 (42.53–1953.23) vs. 113.8 (0.00–823.00) (mcg/L); p < 0.001), while both the Nigerian mothers and infants had higher α:γ-tocopherol ratios (8.5 vs. 26.2, and 8.9 vs. 18.8, respectively; p < 0.001). Our results in both populations show associations between increased circulating γ-tocopherol and negative outcomes like Caesarian sections, in contrast to the associations with positive outcomes such as vaginal delivery seen with increased α:γ-tocopherol ratios. Growth was positively associated with α- and γ-tocopherols in cord blood in the US population, and with cord blood δ-tocopherols in the Nigerian population. Tocopherol levels likely impact health outcomes in pregnancy in a complicated metabolism across the maternal–fetal axis that appears to be potentially influenced by culture and available diet.
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spelling pubmed-61638682018-10-10 A Comparison of Vitamin E Status and Associated Pregnancy Outcomes in Maternal–Infant Dyads between a Nigerian and a United States Population Cave, Caleb Hanson, Corrine Schumacher, Marina Lyden, Elizabeth Furtado, Jeremy Obaro, Stephen Delair, Shirley Kocmich, Nicholas Rezac, Amy Izevbigie, NI Van Ormer, Matthew Kamil, Ammar McGinn, Elizabeth Rilett, Katherine Elliott, Elizabeth Johnson, Rebecca Weishaar, Kara Olateju, EK Akaba, GA Anigilaje, EA Tahiru, Tahiru Anderson-Berry, Ann Nutrients Article Oxidative stress is associated with adverse pregnancy outcomes, and vitamin E has powerful anti-oxidant properties with the potential to impact health outcomes. Tocopherol isomers of vitamin E differ in their ability to modulate inflammation and vary in concentration in diets containing high proportions of processed versus unprocessed foods. The purpose of this study was to compare vitamin E status and associated pregnancy outcomes (mode of delivery, chorioamnionitis, APGARs (measure of appearance, pulse, grimace, activity, respiration), gestational age at delivery, and fetal growth) between maternal–infant dyads in a developed and a developing nation to identify potentially modifiable differences that may impact pregnancy and neonatal outcomes and provide a way to improve maternal and neonatal health. Plasma tocopherol levels were evaluated in 189 Midwestern United States (US) mother–infant pairs and 99 Central Nigerian mother–infant pairs. Maternal and infant concentrations of α-, γ-, and δ-tocopherol were measured using HPLC with diode-array detection. Descriptive statistics were calculated and tocopherol concentrations were associated with clinical outcomes such as mode of delivery, chorioamnionitis, APGARS, and fetal growth. Alpha- and γ-tocopherol levels were higher in the US mothers, (alpha: 12,357.9 (175.23–34,687.75) vs. 8333.1 (1576.59–16,248.40) (mcg/L); p < 0.001) (gamma: 340.7 (224.59–4385.95) vs. 357.5 (66.36–1775.31) (mcg/L); p < 0.001), while δ-tocopherol levels were higher in the Nigerian mothers (delta: 261.7 (24.70–1324.71) vs. 368.9 (43.06–1886.47) (mcg/L); p < 0.001). US infants had higher γ-tocopherol levels than Nigerian infants (203.1 (42.53–1953.23) vs. 113.8 (0.00–823.00) (mcg/L); p < 0.001), while both the Nigerian mothers and infants had higher α:γ-tocopherol ratios (8.5 vs. 26.2, and 8.9 vs. 18.8, respectively; p < 0.001). Our results in both populations show associations between increased circulating γ-tocopherol and negative outcomes like Caesarian sections, in contrast to the associations with positive outcomes such as vaginal delivery seen with increased α:γ-tocopherol ratios. Growth was positively associated with α- and γ-tocopherols in cord blood in the US population, and with cord blood δ-tocopherols in the Nigerian population. Tocopherol levels likely impact health outcomes in pregnancy in a complicated metabolism across the maternal–fetal axis that appears to be potentially influenced by culture and available diet. MDPI 2018-09-14 /pmc/articles/PMC6163868/ /pubmed/30223433 http://dx.doi.org/10.3390/nu10091300 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cave, Caleb
Hanson, Corrine
Schumacher, Marina
Lyden, Elizabeth
Furtado, Jeremy
Obaro, Stephen
Delair, Shirley
Kocmich, Nicholas
Rezac, Amy
Izevbigie, NI
Van Ormer, Matthew
Kamil, Ammar
McGinn, Elizabeth
Rilett, Katherine
Elliott, Elizabeth
Johnson, Rebecca
Weishaar, Kara
Olateju, EK
Akaba, GA
Anigilaje, EA
Tahiru, Tahiru
Anderson-Berry, Ann
A Comparison of Vitamin E Status and Associated Pregnancy Outcomes in Maternal–Infant Dyads between a Nigerian and a United States Population
title A Comparison of Vitamin E Status and Associated Pregnancy Outcomes in Maternal–Infant Dyads between a Nigerian and a United States Population
title_full A Comparison of Vitamin E Status and Associated Pregnancy Outcomes in Maternal–Infant Dyads between a Nigerian and a United States Population
title_fullStr A Comparison of Vitamin E Status and Associated Pregnancy Outcomes in Maternal–Infant Dyads between a Nigerian and a United States Population
title_full_unstemmed A Comparison of Vitamin E Status and Associated Pregnancy Outcomes in Maternal–Infant Dyads between a Nigerian and a United States Population
title_short A Comparison of Vitamin E Status and Associated Pregnancy Outcomes in Maternal–Infant Dyads between a Nigerian and a United States Population
title_sort comparison of vitamin e status and associated pregnancy outcomes in maternal–infant dyads between a nigerian and a united states population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163868/
https://www.ncbi.nlm.nih.gov/pubmed/30223433
http://dx.doi.org/10.3390/nu10091300
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