Who’s Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling

As essential components of the host’s innate immune response, NFκB and interferon signaling are critical determinants of the outcome of infection. Over the past 25 years, numerous Human Cytomegalovirus (HCMV) genes have been identified that antagonize or modulate the signaling of these pathways. Her...

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Autores principales: Goodwin, Christopher M., Ciesla, Jessica H., Munger, Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163874/
https://www.ncbi.nlm.nih.gov/pubmed/30134546
http://dx.doi.org/10.3390/v10090447
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author Goodwin, Christopher M.
Ciesla, Jessica H.
Munger, Joshua
author_facet Goodwin, Christopher M.
Ciesla, Jessica H.
Munger, Joshua
author_sort Goodwin, Christopher M.
collection PubMed
description As essential components of the host’s innate immune response, NFκB and interferon signaling are critical determinants of the outcome of infection. Over the past 25 years, numerous Human Cytomegalovirus (HCMV) genes have been identified that antagonize or modulate the signaling of these pathways. Here we review the biology of the HCMV factors that alter NFκB and interferon signaling, including what is currently known about how these viral genes contribute to infection and persistence, as well as the major outstanding questions that remain.
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spelling pubmed-61638742018-10-11 Who’s Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling Goodwin, Christopher M. Ciesla, Jessica H. Munger, Joshua Viruses Review As essential components of the host’s innate immune response, NFκB and interferon signaling are critical determinants of the outcome of infection. Over the past 25 years, numerous Human Cytomegalovirus (HCMV) genes have been identified that antagonize or modulate the signaling of these pathways. Here we review the biology of the HCMV factors that alter NFκB and interferon signaling, including what is currently known about how these viral genes contribute to infection and persistence, as well as the major outstanding questions that remain. MDPI 2018-08-21 /pmc/articles/PMC6163874/ /pubmed/30134546 http://dx.doi.org/10.3390/v10090447 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Goodwin, Christopher M.
Ciesla, Jessica H.
Munger, Joshua
Who’s Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling
title Who’s Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling
title_full Who’s Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling
title_fullStr Who’s Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling
title_full_unstemmed Who’s Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling
title_short Who’s Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling
title_sort who’s driving? human cytomegalovirus, interferon, and nfκb signaling
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163874/
https://www.ncbi.nlm.nih.gov/pubmed/30134546
http://dx.doi.org/10.3390/v10090447
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