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Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project
Coffee is one of the most widely consumed drinks around the world, while depression is considered the major contributor to the overall global burden of disease. However, the investigation on coffee consumption and depression is limited and results may be confounded by the overall dietary pattern. We...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163886/ https://www.ncbi.nlm.nih.gov/pubmed/30235886 http://dx.doi.org/10.3390/nu10091333 |
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author | Navarro, Adela M. Abasheva, Daria Martínez-González, Miguel Á. Ruiz-Estigarribia, Liz Martín-Calvo, Nerea Sánchez-Villegas, Almudena Toledo, Estefanía |
author_facet | Navarro, Adela M. Abasheva, Daria Martínez-González, Miguel Á. Ruiz-Estigarribia, Liz Martín-Calvo, Nerea Sánchez-Villegas, Almudena Toledo, Estefanía |
author_sort | Navarro, Adela M. |
collection | PubMed |
description | Coffee is one of the most widely consumed drinks around the world, while depression is considered the major contributor to the overall global burden of disease. However, the investigation on coffee consumption and depression is limited and results may be confounded by the overall dietary pattern. We assessed the relationship between coffee intake and the risk of depression, controlling for adherence to the Mediterranean diet. We studied 14,413 university graduates of the ‘Seguimiento Universidad de Navarra’ (SUN) cohort, initially free of depression. We evaluated coffee consumption using a validated food-frequency questionnaire (FFQ). Incident depression cases were adjudicated only if the participant met two criteria simultaneously: (a) validated physician-diagnosed depression together with (b) new onset of habitual antidepressant use. Both criteria were needed; participants meeting only one of them were not classified as cases. Participants who drank at least four cups of coffee per day showed a significantly lower risk of depression than participants who drank less than one cup of coffee per day (HR: 0.37 (95% CI 0.15–0.95)). However, overall, we did not observe an inverse linear dose–response association between coffee consumption and the incidence of depression (p for trend = 0.22). |
format | Online Article Text |
id | pubmed-6163886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61638862018-10-10 Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project Navarro, Adela M. Abasheva, Daria Martínez-González, Miguel Á. Ruiz-Estigarribia, Liz Martín-Calvo, Nerea Sánchez-Villegas, Almudena Toledo, Estefanía Nutrients Article Coffee is one of the most widely consumed drinks around the world, while depression is considered the major contributor to the overall global burden of disease. However, the investigation on coffee consumption and depression is limited and results may be confounded by the overall dietary pattern. We assessed the relationship between coffee intake and the risk of depression, controlling for adherence to the Mediterranean diet. We studied 14,413 university graduates of the ‘Seguimiento Universidad de Navarra’ (SUN) cohort, initially free of depression. We evaluated coffee consumption using a validated food-frequency questionnaire (FFQ). Incident depression cases were adjudicated only if the participant met two criteria simultaneously: (a) validated physician-diagnosed depression together with (b) new onset of habitual antidepressant use. Both criteria were needed; participants meeting only one of them were not classified as cases. Participants who drank at least four cups of coffee per day showed a significantly lower risk of depression than participants who drank less than one cup of coffee per day (HR: 0.37 (95% CI 0.15–0.95)). However, overall, we did not observe an inverse linear dose–response association between coffee consumption and the incidence of depression (p for trend = 0.22). MDPI 2018-09-19 /pmc/articles/PMC6163886/ /pubmed/30235886 http://dx.doi.org/10.3390/nu10091333 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Navarro, Adela M. Abasheva, Daria Martínez-González, Miguel Á. Ruiz-Estigarribia, Liz Martín-Calvo, Nerea Sánchez-Villegas, Almudena Toledo, Estefanía Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project |
title | Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project |
title_full | Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project |
title_fullStr | Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project |
title_full_unstemmed | Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project |
title_short | Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project |
title_sort | coffee consumption and the risk of depression in a middle-aged cohort: the sun project |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163886/ https://www.ncbi.nlm.nih.gov/pubmed/30235886 http://dx.doi.org/10.3390/nu10091333 |
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