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Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project

Coffee is one of the most widely consumed drinks around the world, while depression is considered the major contributor to the overall global burden of disease. However, the investigation on coffee consumption and depression is limited and results may be confounded by the overall dietary pattern. We...

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Autores principales: Navarro, Adela M., Abasheva, Daria, Martínez-González, Miguel Á., Ruiz-Estigarribia, Liz, Martín-Calvo, Nerea, Sánchez-Villegas, Almudena, Toledo, Estefanía
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163886/
https://www.ncbi.nlm.nih.gov/pubmed/30235886
http://dx.doi.org/10.3390/nu10091333
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author Navarro, Adela M.
Abasheva, Daria
Martínez-González, Miguel Á.
Ruiz-Estigarribia, Liz
Martín-Calvo, Nerea
Sánchez-Villegas, Almudena
Toledo, Estefanía
author_facet Navarro, Adela M.
Abasheva, Daria
Martínez-González, Miguel Á.
Ruiz-Estigarribia, Liz
Martín-Calvo, Nerea
Sánchez-Villegas, Almudena
Toledo, Estefanía
author_sort Navarro, Adela M.
collection PubMed
description Coffee is one of the most widely consumed drinks around the world, while depression is considered the major contributor to the overall global burden of disease. However, the investigation on coffee consumption and depression is limited and results may be confounded by the overall dietary pattern. We assessed the relationship between coffee intake and the risk of depression, controlling for adherence to the Mediterranean diet. We studied 14,413 university graduates of the ‘Seguimiento Universidad de Navarra’ (SUN) cohort, initially free of depression. We evaluated coffee consumption using a validated food-frequency questionnaire (FFQ). Incident depression cases were adjudicated only if the participant met two criteria simultaneously: (a) validated physician-diagnosed depression together with (b) new onset of habitual antidepressant use. Both criteria were needed; participants meeting only one of them were not classified as cases. Participants who drank at least four cups of coffee per day showed a significantly lower risk of depression than participants who drank less than one cup of coffee per day (HR: 0.37 (95% CI 0.15–0.95)). However, overall, we did not observe an inverse linear dose–response association between coffee consumption and the incidence of depression (p for trend = 0.22).
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spelling pubmed-61638862018-10-10 Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project Navarro, Adela M. Abasheva, Daria Martínez-González, Miguel Á. Ruiz-Estigarribia, Liz Martín-Calvo, Nerea Sánchez-Villegas, Almudena Toledo, Estefanía Nutrients Article Coffee is one of the most widely consumed drinks around the world, while depression is considered the major contributor to the overall global burden of disease. However, the investigation on coffee consumption and depression is limited and results may be confounded by the overall dietary pattern. We assessed the relationship between coffee intake and the risk of depression, controlling for adherence to the Mediterranean diet. We studied 14,413 university graduates of the ‘Seguimiento Universidad de Navarra’ (SUN) cohort, initially free of depression. We evaluated coffee consumption using a validated food-frequency questionnaire (FFQ). Incident depression cases were adjudicated only if the participant met two criteria simultaneously: (a) validated physician-diagnosed depression together with (b) new onset of habitual antidepressant use. Both criteria were needed; participants meeting only one of them were not classified as cases. Participants who drank at least four cups of coffee per day showed a significantly lower risk of depression than participants who drank less than one cup of coffee per day (HR: 0.37 (95% CI 0.15–0.95)). However, overall, we did not observe an inverse linear dose–response association between coffee consumption and the incidence of depression (p for trend = 0.22). MDPI 2018-09-19 /pmc/articles/PMC6163886/ /pubmed/30235886 http://dx.doi.org/10.3390/nu10091333 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Navarro, Adela M.
Abasheva, Daria
Martínez-González, Miguel Á.
Ruiz-Estigarribia, Liz
Martín-Calvo, Nerea
Sánchez-Villegas, Almudena
Toledo, Estefanía
Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project
title Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project
title_full Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project
title_fullStr Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project
title_full_unstemmed Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project
title_short Coffee Consumption and the Risk of Depression in a Middle-Aged Cohort: The SUN Project
title_sort coffee consumption and the risk of depression in a middle-aged cohort: the sun project
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163886/
https://www.ncbi.nlm.nih.gov/pubmed/30235886
http://dx.doi.org/10.3390/nu10091333
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