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Porous Titanium Scaffolds Fabricated by Metal Injection Moulding for Biomedical Applications

Biocompatible titanium scaffolds with up to 40% interconnected porosity were manufactured through the metal injection moulding process and the space holder technique. The mechanical properties of the manufactured scaffold showed a high level of compatibility with those of the cortical human bone. Si...

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Autores principales: Dehghan-Manshadi, Ali, Chen, Yunhui, Shi, Zhiming, Bermingham, Michael, StJohn, David, Dargusch, Matthew, Qian, Ma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163891/
https://www.ncbi.nlm.nih.gov/pubmed/30200402
http://dx.doi.org/10.3390/ma11091573
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author Dehghan-Manshadi, Ali
Chen, Yunhui
Shi, Zhiming
Bermingham, Michael
StJohn, David
Dargusch, Matthew
Qian, Ma
author_facet Dehghan-Manshadi, Ali
Chen, Yunhui
Shi, Zhiming
Bermingham, Michael
StJohn, David
Dargusch, Matthew
Qian, Ma
author_sort Dehghan-Manshadi, Ali
collection PubMed
description Biocompatible titanium scaffolds with up to 40% interconnected porosity were manufactured through the metal injection moulding process and the space holder technique. The mechanical properties of the manufactured scaffold showed a high level of compatibility with those of the cortical human bone. Sintering at 1250 °C produced scaffolds with 36% porosity and more than 90% interconnected pores, a compressive yield stress of 220 MPa and a Young’s modulus of 7.80 GPa, all suitable for bone tissue engineering. Increasing the sintering temperature to 1300 °C increased the Young’s modulus to 22.0 GPa due to reduced porosity, while reducing the sintering temperature to 1150 °C lowered the yield stress to 120 MPa, indicative of insufficient sintering. Electrochemical studies revealed that samples sintered at 1150 °C have a higher corrosion rate compared with those at a sintering temperature of 1250 °C. Overall, it was concluded that sintering at 1250 °C yielded the most desirable results.
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spelling pubmed-61638912018-10-12 Porous Titanium Scaffolds Fabricated by Metal Injection Moulding for Biomedical Applications Dehghan-Manshadi, Ali Chen, Yunhui Shi, Zhiming Bermingham, Michael StJohn, David Dargusch, Matthew Qian, Ma Materials (Basel) Article Biocompatible titanium scaffolds with up to 40% interconnected porosity were manufactured through the metal injection moulding process and the space holder technique. The mechanical properties of the manufactured scaffold showed a high level of compatibility with those of the cortical human bone. Sintering at 1250 °C produced scaffolds with 36% porosity and more than 90% interconnected pores, a compressive yield stress of 220 MPa and a Young’s modulus of 7.80 GPa, all suitable for bone tissue engineering. Increasing the sintering temperature to 1300 °C increased the Young’s modulus to 22.0 GPa due to reduced porosity, while reducing the sintering temperature to 1150 °C lowered the yield stress to 120 MPa, indicative of insufficient sintering. Electrochemical studies revealed that samples sintered at 1150 °C have a higher corrosion rate compared with those at a sintering temperature of 1250 °C. Overall, it was concluded that sintering at 1250 °C yielded the most desirable results. MDPI 2018-09-01 /pmc/articles/PMC6163891/ /pubmed/30200402 http://dx.doi.org/10.3390/ma11091573 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dehghan-Manshadi, Ali
Chen, Yunhui
Shi, Zhiming
Bermingham, Michael
StJohn, David
Dargusch, Matthew
Qian, Ma
Porous Titanium Scaffolds Fabricated by Metal Injection Moulding for Biomedical Applications
title Porous Titanium Scaffolds Fabricated by Metal Injection Moulding for Biomedical Applications
title_full Porous Titanium Scaffolds Fabricated by Metal Injection Moulding for Biomedical Applications
title_fullStr Porous Titanium Scaffolds Fabricated by Metal Injection Moulding for Biomedical Applications
title_full_unstemmed Porous Titanium Scaffolds Fabricated by Metal Injection Moulding for Biomedical Applications
title_short Porous Titanium Scaffolds Fabricated by Metal Injection Moulding for Biomedical Applications
title_sort porous titanium scaffolds fabricated by metal injection moulding for biomedical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163891/
https://www.ncbi.nlm.nih.gov/pubmed/30200402
http://dx.doi.org/10.3390/ma11091573
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