Breast Cancer Stem Cells

Breast cancer stem cells (BCSC) have been implicated in tumor initiation, progression, metastasis, recurrence, and resistance to therapy. The origins of BCSCs remain controversial due to tumor heterogeneity and the presence of such small side populations for study, but nonetheless, cell surface mark...

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Detalles Bibliográficos
Autores principales: Crabtree, Judy S., Miele, Lucio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163894/
https://www.ncbi.nlm.nih.gov/pubmed/30018256
http://dx.doi.org/10.3390/biomedicines6030077
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author Crabtree, Judy S.
Miele, Lucio
author_facet Crabtree, Judy S.
Miele, Lucio
author_sort Crabtree, Judy S.
collection PubMed
description Breast cancer stem cells (BCSC) have been implicated in tumor initiation, progression, metastasis, recurrence, and resistance to therapy. The origins of BCSCs remain controversial due to tumor heterogeneity and the presence of such small side populations for study, but nonetheless, cell surface markers and their correlation with BCSC functionality continue to be identified. BCSCs are driven by persistent activation of developmental pathways, such as Notch, Wnt, Hippo, and Hedgehog and new treatment strategies that are aimed at these pathways are in preclinical and clinical development.
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spelling pubmed-61638942018-10-11 Breast Cancer Stem Cells Crabtree, Judy S. Miele, Lucio Biomedicines Review Breast cancer stem cells (BCSC) have been implicated in tumor initiation, progression, metastasis, recurrence, and resistance to therapy. The origins of BCSCs remain controversial due to tumor heterogeneity and the presence of such small side populations for study, but nonetheless, cell surface markers and their correlation with BCSC functionality continue to be identified. BCSCs are driven by persistent activation of developmental pathways, such as Notch, Wnt, Hippo, and Hedgehog and new treatment strategies that are aimed at these pathways are in preclinical and clinical development. MDPI 2018-07-17 /pmc/articles/PMC6163894/ /pubmed/30018256 http://dx.doi.org/10.3390/biomedicines6030077 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Crabtree, Judy S.
Miele, Lucio
Breast Cancer Stem Cells
title Breast Cancer Stem Cells
title_full Breast Cancer Stem Cells
title_fullStr Breast Cancer Stem Cells
title_full_unstemmed Breast Cancer Stem Cells
title_short Breast Cancer Stem Cells
title_sort breast cancer stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163894/
https://www.ncbi.nlm.nih.gov/pubmed/30018256
http://dx.doi.org/10.3390/biomedicines6030077
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