Hyperglycemia-Associated Dysregulation of O-GlcNAcylation and HIF1A Reduces Anticancer Action of Metformin in Ovarian Cancer Cells (SKOV-3)

Although cancer cells need more glucose than normal cells to maintain energy demand, chronic hyperglycemia induces metabolic alteration that may dysregulate signaling pathways, including the O-GlcNAcylation and HIF1A (Hypoxia-inducible factor 1-alpha) pathways. Metformin was demonstrated to evoke me...

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Detalles Bibliográficos
Autores principales: Rogalska, Aneta, Forma, Ewa, Bryś, Magdalena, Śliwińska, Agnieszka, Marczak, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163973/
https://www.ncbi.nlm.nih.gov/pubmed/30217067
http://dx.doi.org/10.3390/ijms19092750

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