Cargando…
Interferon-Mediated Response to Human Metapneumovirus Infection
Human metapneumovirus (HMPV) is one of the leading causes of respiratory diseases in infants and children worldwide. Although this pathogen infects mainly young children, elderly and immunocompromised people can be also seriously affected. To date, there is no commercial vaccine available against it...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163993/ https://www.ncbi.nlm.nih.gov/pubmed/30231515 http://dx.doi.org/10.3390/v10090505 |
_version_ | 1783359494349127680 |
---|---|
author | Uche, Ifeanyi K. Guerrero-Plata, Antonieta |
author_facet | Uche, Ifeanyi K. Guerrero-Plata, Antonieta |
author_sort | Uche, Ifeanyi K. |
collection | PubMed |
description | Human metapneumovirus (HMPV) is one of the leading causes of respiratory diseases in infants and children worldwide. Although this pathogen infects mainly young children, elderly and immunocompromised people can be also seriously affected. To date, there is no commercial vaccine available against it. Upon HMPV infection, the host innate arm of defense produces interferons (IFNs), which are critical for limiting HMPV replication. In this review, we offer an updated landscape of the HMPV mediated-IFN response in different models as well as some of the defense tactics employed by the virus to circumvent IFN response. |
format | Online Article Text |
id | pubmed-6163993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61639932018-10-11 Interferon-Mediated Response to Human Metapneumovirus Infection Uche, Ifeanyi K. Guerrero-Plata, Antonieta Viruses Review Human metapneumovirus (HMPV) is one of the leading causes of respiratory diseases in infants and children worldwide. Although this pathogen infects mainly young children, elderly and immunocompromised people can be also seriously affected. To date, there is no commercial vaccine available against it. Upon HMPV infection, the host innate arm of defense produces interferons (IFNs), which are critical for limiting HMPV replication. In this review, we offer an updated landscape of the HMPV mediated-IFN response in different models as well as some of the defense tactics employed by the virus to circumvent IFN response. MDPI 2018-09-18 /pmc/articles/PMC6163993/ /pubmed/30231515 http://dx.doi.org/10.3390/v10090505 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Uche, Ifeanyi K. Guerrero-Plata, Antonieta Interferon-Mediated Response to Human Metapneumovirus Infection |
title | Interferon-Mediated Response to Human Metapneumovirus Infection |
title_full | Interferon-Mediated Response to Human Metapneumovirus Infection |
title_fullStr | Interferon-Mediated Response to Human Metapneumovirus Infection |
title_full_unstemmed | Interferon-Mediated Response to Human Metapneumovirus Infection |
title_short | Interferon-Mediated Response to Human Metapneumovirus Infection |
title_sort | interferon-mediated response to human metapneumovirus infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163993/ https://www.ncbi.nlm.nih.gov/pubmed/30231515 http://dx.doi.org/10.3390/v10090505 |
work_keys_str_mv | AT ucheifeanyik interferonmediatedresponsetohumanmetapneumovirusinfection AT guerreroplataantonieta interferonmediatedresponsetohumanmetapneumovirusinfection |