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Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review

Magnetic nanoparticles (MNPs) have great potential in biomedical and clinical applications because of their many unique properties. This contribution provides an overview of the MNPs mainly used in the field of amyloid diseases. The first part discusses their use in understanding the amyloid mechani...

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Autores principales: Pansieri, Jonathan, Gerstenmayer, Matthieu, Lux, François, Mériaux, Sebastien, Tillement, Olivier, Forge, Vincent, Larrat, Benoit, Marquette, Christel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164038/
https://www.ncbi.nlm.nih.gov/pubmed/30231587
http://dx.doi.org/10.3390/nano8090740
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author Pansieri, Jonathan
Gerstenmayer, Matthieu
Lux, François
Mériaux, Sebastien
Tillement, Olivier
Forge, Vincent
Larrat, Benoit
Marquette, Christel
author_facet Pansieri, Jonathan
Gerstenmayer, Matthieu
Lux, François
Mériaux, Sebastien
Tillement, Olivier
Forge, Vincent
Larrat, Benoit
Marquette, Christel
author_sort Pansieri, Jonathan
collection PubMed
description Magnetic nanoparticles (MNPs) have great potential in biomedical and clinical applications because of their many unique properties. This contribution provides an overview of the MNPs mainly used in the field of amyloid diseases. The first part discusses their use in understanding the amyloid mechanisms of fibrillation, with emphasis on their ability to control aggregation of amyloidogenic proteins. The second part deals with the functionalization by various moieties of numerous MNPs’ surfaces (molecules, peptides, antibody fragments, or whole antibodies of MNPs) for the detection and the quantification of amyloid aggregates. The last part of this review focuses on the use of MNPs for magnetic-resonance-based amyloid imaging in biomedical fields, with particular attention to the application of gadolinium-based paramagnetic nanoparticles (AGuIX), which have been recently developed. Biocompatible AGuIX nanoparticles show favorable characteristics for in vivo use, such as nanometric and straightforward functionalization. Their properties have enabled their application in MRI. Here, we report that AGuIX nanoparticles grafted with the Pittsburgh compound B can actively target amyloid aggregates in the brain, beyond the blood–brain barrier, and remain the first step in observing amyloid plaques in a mouse model of Alzheimer’s disease.
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spelling pubmed-61640382018-10-10 Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review Pansieri, Jonathan Gerstenmayer, Matthieu Lux, François Mériaux, Sebastien Tillement, Olivier Forge, Vincent Larrat, Benoit Marquette, Christel Nanomaterials (Basel) Review Magnetic nanoparticles (MNPs) have great potential in biomedical and clinical applications because of their many unique properties. This contribution provides an overview of the MNPs mainly used in the field of amyloid diseases. The first part discusses their use in understanding the amyloid mechanisms of fibrillation, with emphasis on their ability to control aggregation of amyloidogenic proteins. The second part deals with the functionalization by various moieties of numerous MNPs’ surfaces (molecules, peptides, antibody fragments, or whole antibodies of MNPs) for the detection and the quantification of amyloid aggregates. The last part of this review focuses on the use of MNPs for magnetic-resonance-based amyloid imaging in biomedical fields, with particular attention to the application of gadolinium-based paramagnetic nanoparticles (AGuIX), which have been recently developed. Biocompatible AGuIX nanoparticles show favorable characteristics for in vivo use, such as nanometric and straightforward functionalization. Their properties have enabled their application in MRI. Here, we report that AGuIX nanoparticles grafted with the Pittsburgh compound B can actively target amyloid aggregates in the brain, beyond the blood–brain barrier, and remain the first step in observing amyloid plaques in a mouse model of Alzheimer’s disease. MDPI 2018-09-18 /pmc/articles/PMC6164038/ /pubmed/30231587 http://dx.doi.org/10.3390/nano8090740 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pansieri, Jonathan
Gerstenmayer, Matthieu
Lux, François
Mériaux, Sebastien
Tillement, Olivier
Forge, Vincent
Larrat, Benoit
Marquette, Christel
Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review
title Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review
title_full Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review
title_fullStr Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review
title_full_unstemmed Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review
title_short Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review
title_sort magnetic nanoparticles applications for amyloidosis study and detection: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164038/
https://www.ncbi.nlm.nih.gov/pubmed/30231587
http://dx.doi.org/10.3390/nano8090740
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