Cargando…

Antimicrobial Usage in Animal Production: A Review of the Literature with a Focus on Low- and Middle-Income Countries

Antimicrobial use (AMU) in animal production is a key contributor to antimicrobial resistance (AMR) worldwide. As consumption of animal protein and associated animal production is forecast to increase markedly over coming years in low- and middle-income countries (LMICs), accurate monitoring of AMU...

Descripción completa

Detalles Bibliográficos
Autores principales: Cuong, Nguyen V., Padungtod, Pawin, Thwaites, Guy, Carrique-Mas, Juan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164101/
https://www.ncbi.nlm.nih.gov/pubmed/30111750
http://dx.doi.org/10.3390/antibiotics7030075
_version_ 1783359520009879552
author Cuong, Nguyen V.
Padungtod, Pawin
Thwaites, Guy
Carrique-Mas, Juan J.
author_facet Cuong, Nguyen V.
Padungtod, Pawin
Thwaites, Guy
Carrique-Mas, Juan J.
author_sort Cuong, Nguyen V.
collection PubMed
description Antimicrobial use (AMU) in animal production is a key contributor to antimicrobial resistance (AMR) worldwide. As consumption of animal protein and associated animal production is forecast to increase markedly over coming years in low- and middle-income countries (LMICs), accurate monitoring of AMU has become imperative. We summarized data from 89 scientific studies reporting AMU data in animal production published in English since 1998, identified through the ‘ISI Web of Knowledge’ search engine. The aims were as follows: (a) to describe methodologies and metrics used to quantify AMU; (b) to summarize qualitative (on-farm prevalence of use) and quantitative (amounts of antimicrobial active principle) data, in order to identify food animal species at the highest risk of AMU; and (c) to highlight data gaps from LMICs. Only 17/89 (19.1%) studies were conducted in LMICs. Sixty (67.3%) reported quantitative data use, with ‘daily doses per animal-time’ being the most common metric. AMU was greatest in chickens (138 doses/1000 animal-days [inter quartile range (IQR) 91.1–438.3]), followed by swine (40.2 [IQR 8.5–120.4]), and dairy cattle (10.0 [IQR 5.5–13.6]). However, per kg of meat produced, AMU was highest in swine, followed by chickens and cattle. Our review highlights a large deficit of data from LMICs, and provides a reference for comparison with further surveillance and research initiatives aiming to reduce AMU in animal production globally.
format Online
Article
Text
id pubmed-6164101
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-61641012018-10-12 Antimicrobial Usage in Animal Production: A Review of the Literature with a Focus on Low- and Middle-Income Countries Cuong, Nguyen V. Padungtod, Pawin Thwaites, Guy Carrique-Mas, Juan J. Antibiotics (Basel) Review Antimicrobial use (AMU) in animal production is a key contributor to antimicrobial resistance (AMR) worldwide. As consumption of animal protein and associated animal production is forecast to increase markedly over coming years in low- and middle-income countries (LMICs), accurate monitoring of AMU has become imperative. We summarized data from 89 scientific studies reporting AMU data in animal production published in English since 1998, identified through the ‘ISI Web of Knowledge’ search engine. The aims were as follows: (a) to describe methodologies and metrics used to quantify AMU; (b) to summarize qualitative (on-farm prevalence of use) and quantitative (amounts of antimicrobial active principle) data, in order to identify food animal species at the highest risk of AMU; and (c) to highlight data gaps from LMICs. Only 17/89 (19.1%) studies were conducted in LMICs. Sixty (67.3%) reported quantitative data use, with ‘daily doses per animal-time’ being the most common metric. AMU was greatest in chickens (138 doses/1000 animal-days [inter quartile range (IQR) 91.1–438.3]), followed by swine (40.2 [IQR 8.5–120.4]), and dairy cattle (10.0 [IQR 5.5–13.6]). However, per kg of meat produced, AMU was highest in swine, followed by chickens and cattle. Our review highlights a large deficit of data from LMICs, and provides a reference for comparison with further surveillance and research initiatives aiming to reduce AMU in animal production globally. MDPI 2018-08-15 /pmc/articles/PMC6164101/ /pubmed/30111750 http://dx.doi.org/10.3390/antibiotics7030075 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cuong, Nguyen V.
Padungtod, Pawin
Thwaites, Guy
Carrique-Mas, Juan J.
Antimicrobial Usage in Animal Production: A Review of the Literature with a Focus on Low- and Middle-Income Countries
title Antimicrobial Usage in Animal Production: A Review of the Literature with a Focus on Low- and Middle-Income Countries
title_full Antimicrobial Usage in Animal Production: A Review of the Literature with a Focus on Low- and Middle-Income Countries
title_fullStr Antimicrobial Usage in Animal Production: A Review of the Literature with a Focus on Low- and Middle-Income Countries
title_full_unstemmed Antimicrobial Usage in Animal Production: A Review of the Literature with a Focus on Low- and Middle-Income Countries
title_short Antimicrobial Usage in Animal Production: A Review of the Literature with a Focus on Low- and Middle-Income Countries
title_sort antimicrobial usage in animal production: a review of the literature with a focus on low- and middle-income countries
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164101/
https://www.ncbi.nlm.nih.gov/pubmed/30111750
http://dx.doi.org/10.3390/antibiotics7030075
work_keys_str_mv AT cuongnguyenv antimicrobialusageinanimalproductionareviewoftheliteraturewithafocusonlowandmiddleincomecountries
AT padungtodpawin antimicrobialusageinanimalproductionareviewoftheliteraturewithafocusonlowandmiddleincomecountries
AT thwaitesguy antimicrobialusageinanimalproductionareviewoftheliteraturewithafocusonlowandmiddleincomecountries
AT carriquemasjuanj antimicrobialusageinanimalproductionareviewoftheliteraturewithafocusonlowandmiddleincomecountries