Cargando…
YKL-40, Soluble IL-2 Receptor, Angiotensin Converting Enzyme and C-Reactive Protein: Comparison of Markers of Sarcoidosis Activity
The aims of this study were to describe the clinical, radiological and immunological features of a population of sarcoidosis patients and to analyse chitinase-3-like protein 1 (YKL-40), soluble interleukin-2 receptor (sIL-2R), neopterin concentrations and adenosine deaminase (ADA) activity in serum...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164141/ https://www.ncbi.nlm.nih.gov/pubmed/30154391 http://dx.doi.org/10.3390/biom8030084 |
_version_ | 1783359529563455488 |
---|---|
author | Uysal, Pelin Durmus, Sinem Sozer, Volkan Gelisgen, Remise Seyhan, Ekrem Cengiz Erdenen, Fusun Simsek, Gonul Uzun, Hafize |
author_facet | Uysal, Pelin Durmus, Sinem Sozer, Volkan Gelisgen, Remise Seyhan, Ekrem Cengiz Erdenen, Fusun Simsek, Gonul Uzun, Hafize |
author_sort | Uysal, Pelin |
collection | PubMed |
description | The aims of this study were to describe the clinical, radiological and immunological features of a population of sarcoidosis patients and to analyse chitinase-3-like protein 1 (YKL-40), soluble interleukin-2 receptor (sIL-2R), neopterin concentrations and adenosine deaminase (ADA) activity in serum of these patients in order to understand their potential as disease markers. Fifty-nine patients affected by chronic sarcoidosis, in active (20 patients) and inactive (39 patients) phase according to the clinical, radiological and laboratory criteria were studied. Serum YKL-40, sIL-2R, high-sensitive C-reactive protein (hs-CRP), neopterin levels and ADA activities were evaluated and compared with those of 25 healthy controls. Individuals with chronic sarcoidosis were significantly higher serum YKL-40, sIL-2R, neopterin, hs-CRP concentrations, angiotensin converting enzyme (ACE) and ADA activity than those of control subjects. Sarcoidosis patients in the active phase of the disease were significantly higher YKL-40, sIL-2R, hs-CRP levels and ACE activity than those in the inactive phase, while ADA activities and neopterin levels did not display any significant difference between the active and inactive disease groups. In comparison to the other parameters, as panel measurement of the serum YKL-40, sIL-2R, ACE and hs-CRP indicate a greater discrimination between active and inactive disease. The results indicate that serum YKL-40, sIL-2R, ACE and hs-CRP concentrations may be useful marker for monitoring sarcoidosis disease activity. |
format | Online Article Text |
id | pubmed-6164141 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61641412018-10-10 YKL-40, Soluble IL-2 Receptor, Angiotensin Converting Enzyme and C-Reactive Protein: Comparison of Markers of Sarcoidosis Activity Uysal, Pelin Durmus, Sinem Sozer, Volkan Gelisgen, Remise Seyhan, Ekrem Cengiz Erdenen, Fusun Simsek, Gonul Uzun, Hafize Biomolecules Article The aims of this study were to describe the clinical, radiological and immunological features of a population of sarcoidosis patients and to analyse chitinase-3-like protein 1 (YKL-40), soluble interleukin-2 receptor (sIL-2R), neopterin concentrations and adenosine deaminase (ADA) activity in serum of these patients in order to understand their potential as disease markers. Fifty-nine patients affected by chronic sarcoidosis, in active (20 patients) and inactive (39 patients) phase according to the clinical, radiological and laboratory criteria were studied. Serum YKL-40, sIL-2R, high-sensitive C-reactive protein (hs-CRP), neopterin levels and ADA activities were evaluated and compared with those of 25 healthy controls. Individuals with chronic sarcoidosis were significantly higher serum YKL-40, sIL-2R, neopterin, hs-CRP concentrations, angiotensin converting enzyme (ACE) and ADA activity than those of control subjects. Sarcoidosis patients in the active phase of the disease were significantly higher YKL-40, sIL-2R, hs-CRP levels and ACE activity than those in the inactive phase, while ADA activities and neopterin levels did not display any significant difference between the active and inactive disease groups. In comparison to the other parameters, as panel measurement of the serum YKL-40, sIL-2R, ACE and hs-CRP indicate a greater discrimination between active and inactive disease. The results indicate that serum YKL-40, sIL-2R, ACE and hs-CRP concentrations may be useful marker for monitoring sarcoidosis disease activity. MDPI 2018-08-28 /pmc/articles/PMC6164141/ /pubmed/30154391 http://dx.doi.org/10.3390/biom8030084 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Uysal, Pelin Durmus, Sinem Sozer, Volkan Gelisgen, Remise Seyhan, Ekrem Cengiz Erdenen, Fusun Simsek, Gonul Uzun, Hafize YKL-40, Soluble IL-2 Receptor, Angiotensin Converting Enzyme and C-Reactive Protein: Comparison of Markers of Sarcoidosis Activity |
title | YKL-40, Soluble IL-2 Receptor, Angiotensin Converting Enzyme and C-Reactive Protein: Comparison of Markers of Sarcoidosis Activity |
title_full | YKL-40, Soluble IL-2 Receptor, Angiotensin Converting Enzyme and C-Reactive Protein: Comparison of Markers of Sarcoidosis Activity |
title_fullStr | YKL-40, Soluble IL-2 Receptor, Angiotensin Converting Enzyme and C-Reactive Protein: Comparison of Markers of Sarcoidosis Activity |
title_full_unstemmed | YKL-40, Soluble IL-2 Receptor, Angiotensin Converting Enzyme and C-Reactive Protein: Comparison of Markers of Sarcoidosis Activity |
title_short | YKL-40, Soluble IL-2 Receptor, Angiotensin Converting Enzyme and C-Reactive Protein: Comparison of Markers of Sarcoidosis Activity |
title_sort | ykl-40, soluble il-2 receptor, angiotensin converting enzyme and c-reactive protein: comparison of markers of sarcoidosis activity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164141/ https://www.ncbi.nlm.nih.gov/pubmed/30154391 http://dx.doi.org/10.3390/biom8030084 |
work_keys_str_mv | AT uysalpelin ykl40solubleil2receptorangiotensinconvertingenzymeandcreactiveproteincomparisonofmarkersofsarcoidosisactivity AT durmussinem ykl40solubleil2receptorangiotensinconvertingenzymeandcreactiveproteincomparisonofmarkersofsarcoidosisactivity AT sozervolkan ykl40solubleil2receptorangiotensinconvertingenzymeandcreactiveproteincomparisonofmarkersofsarcoidosisactivity AT gelisgenremise ykl40solubleil2receptorangiotensinconvertingenzymeandcreactiveproteincomparisonofmarkersofsarcoidosisactivity AT seyhanekremcengiz ykl40solubleil2receptorangiotensinconvertingenzymeandcreactiveproteincomparisonofmarkersofsarcoidosisactivity AT erdenenfusun ykl40solubleil2receptorangiotensinconvertingenzymeandcreactiveproteincomparisonofmarkersofsarcoidosisactivity AT simsekgonul ykl40solubleil2receptorangiotensinconvertingenzymeandcreactiveproteincomparisonofmarkersofsarcoidosisactivity AT uzunhafize ykl40solubleil2receptorangiotensinconvertingenzymeandcreactiveproteincomparisonofmarkersofsarcoidosisactivity |