BK Polyomavirus MicroRNA Levels in Exosomes Are Modulated by Non-Coding Control Region Activity and Down-Regulate Viral Replication When Delivered to Non-Infected Cells Prior to Infection

In immunosuppressed patients, BKPyV-variants emerge carrying rearranged non-coding control-regions (rr-NCCRs) that increase early viral gene region (EVGR) expression and replication capacity. BKPyV also encodes microRNAs, which have been reported to downregulate EVGR-encoded large T-antigen transcri...

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Detalles Bibliográficos
Autores principales: Martelli, Francesco, Wu, Zongsong, Delbue, Serena, Weissbach, Fabian H., Giulioli, Maria Chiara, Ferrante, Pasquale, Hirsch, Hans H., Giannecchini, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164188/
https://www.ncbi.nlm.nih.gov/pubmed/30200237
http://dx.doi.org/10.3390/v10090466

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