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Inside the Endometrial Cell Signaling Subway: Mind the Gap(s)

Endometrial cells perceive and respond to their microenvironment forming the basis of endometrial homeostasis. Errors in endometrial cell signaling are responsible for a wide spectrum of endometrial pathologies ranging from infertility to cancer. Intensive research over the years has been decoding t...

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Autores principales: Makieva, Sofia, Giacomini, Elisa, Ottolina, Jessica, Sanchez, Ana Maria, Papaleo, Enrico, Viganò, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164241/
https://www.ncbi.nlm.nih.gov/pubmed/30134622
http://dx.doi.org/10.3390/ijms19092477
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author Makieva, Sofia
Giacomini, Elisa
Ottolina, Jessica
Sanchez, Ana Maria
Papaleo, Enrico
Viganò, Paola
author_facet Makieva, Sofia
Giacomini, Elisa
Ottolina, Jessica
Sanchez, Ana Maria
Papaleo, Enrico
Viganò, Paola
author_sort Makieva, Sofia
collection PubMed
description Endometrial cells perceive and respond to their microenvironment forming the basis of endometrial homeostasis. Errors in endometrial cell signaling are responsible for a wide spectrum of endometrial pathologies ranging from infertility to cancer. Intensive research over the years has been decoding the sophisticated molecular means by which endometrial cells communicate to each other and with the embryo. The objective of this review is to provide the scientific community with the first overview of key endometrial cell signaling pathways operating throughout the menstrual cycle. On this basis, a comprehensive and critical assessment of the literature was performed to provide the tools for the authorship of this narrative review summarizing the pivotal components and signaling cascades operating during seven endometrial cell fate “routes”: proliferation, decidualization, implantation, migration, breakdown, regeneration, and angiogenesis. Albeit schematically presented as separate transit routes in a subway network and narrated in a distinct fashion, the majority of the time these routes overlap or occur simultaneously within endometrial cells. This review facilitates identification of novel trajectories of research in endometrial cellular communication and signaling. The meticulous study of endometrial signaling pathways potentiates both the discovery of novel therapeutic targets to tackle disease and vanguard fertility approaches.
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spelling pubmed-61642412018-10-10 Inside the Endometrial Cell Signaling Subway: Mind the Gap(s) Makieva, Sofia Giacomini, Elisa Ottolina, Jessica Sanchez, Ana Maria Papaleo, Enrico Viganò, Paola Int J Mol Sci Review Endometrial cells perceive and respond to their microenvironment forming the basis of endometrial homeostasis. Errors in endometrial cell signaling are responsible for a wide spectrum of endometrial pathologies ranging from infertility to cancer. Intensive research over the years has been decoding the sophisticated molecular means by which endometrial cells communicate to each other and with the embryo. The objective of this review is to provide the scientific community with the first overview of key endometrial cell signaling pathways operating throughout the menstrual cycle. On this basis, a comprehensive and critical assessment of the literature was performed to provide the tools for the authorship of this narrative review summarizing the pivotal components and signaling cascades operating during seven endometrial cell fate “routes”: proliferation, decidualization, implantation, migration, breakdown, regeneration, and angiogenesis. Albeit schematically presented as separate transit routes in a subway network and narrated in a distinct fashion, the majority of the time these routes overlap or occur simultaneously within endometrial cells. This review facilitates identification of novel trajectories of research in endometrial cellular communication and signaling. The meticulous study of endometrial signaling pathways potentiates both the discovery of novel therapeutic targets to tackle disease and vanguard fertility approaches. MDPI 2018-08-21 /pmc/articles/PMC6164241/ /pubmed/30134622 http://dx.doi.org/10.3390/ijms19092477 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Makieva, Sofia
Giacomini, Elisa
Ottolina, Jessica
Sanchez, Ana Maria
Papaleo, Enrico
Viganò, Paola
Inside the Endometrial Cell Signaling Subway: Mind the Gap(s)
title Inside the Endometrial Cell Signaling Subway: Mind the Gap(s)
title_full Inside the Endometrial Cell Signaling Subway: Mind the Gap(s)
title_fullStr Inside the Endometrial Cell Signaling Subway: Mind the Gap(s)
title_full_unstemmed Inside the Endometrial Cell Signaling Subway: Mind the Gap(s)
title_short Inside the Endometrial Cell Signaling Subway: Mind the Gap(s)
title_sort inside the endometrial cell signaling subway: mind the gap(s)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164241/
https://www.ncbi.nlm.nih.gov/pubmed/30134622
http://dx.doi.org/10.3390/ijms19092477
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