Cargando…
Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers
Silymarin-loaded mucoadhesive microbeads of Chitosan-MMT were developed using the ionotropic gelation technique. Characterization of the microbeads was performed by DSC, XRD, SEM, and FTIR techniques. In vitro mucoadhesion and drug release studies; gastroprotective studies including the measurement...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164251/ https://www.ncbi.nlm.nih.gov/pubmed/30201932 http://dx.doi.org/10.3390/jfb9030052 |
_version_ | 1783359555165487104 |
---|---|
author | Sharma, Ameya Puri, Vivek Kakkar, Vandita Singh, Inderbir |
author_facet | Sharma, Ameya Puri, Vivek Kakkar, Vandita Singh, Inderbir |
author_sort | Sharma, Ameya |
collection | PubMed |
description | Silymarin-loaded mucoadhesive microbeads of Chitosan-MMT were developed using the ionotropic gelation technique. Characterization of the microbeads was performed by DSC, XRD, SEM, and FTIR techniques. In vitro mucoadhesion and drug release studies; gastroprotective studies including the measurement of ulcerative index; the determination of gastric wall mucus; and the determination of percentage protection, biochemical, and histopathological studies were also performed. Microbeads batches were evaluated for particle size (120–140 µm), actual drug content, (49.36–58.18%) and entrapment efficiency (72.52–92.39%).Biochemical estimation of myeloperoxidase was found to be 0.10–0.75 µmoles/g/tissue. Significant reduction in the ulcerative index showed the gastroprotective effect of the formulation. Silymarin-loaded beads of Chitosan-MMT were found to exhibit good mucoadhesion and efficient release of the drug, and were found to be a promising drug carrier system for the treatment of gastric ulcers. |
format | Online Article Text |
id | pubmed-6164251 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61642512018-10-12 Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers Sharma, Ameya Puri, Vivek Kakkar, Vandita Singh, Inderbir J Funct Biomater Article Silymarin-loaded mucoadhesive microbeads of Chitosan-MMT were developed using the ionotropic gelation technique. Characterization of the microbeads was performed by DSC, XRD, SEM, and FTIR techniques. In vitro mucoadhesion and drug release studies; gastroprotective studies including the measurement of ulcerative index; the determination of gastric wall mucus; and the determination of percentage protection, biochemical, and histopathological studies were also performed. Microbeads batches were evaluated for particle size (120–140 µm), actual drug content, (49.36–58.18%) and entrapment efficiency (72.52–92.39%).Biochemical estimation of myeloperoxidase was found to be 0.10–0.75 µmoles/g/tissue. Significant reduction in the ulcerative index showed the gastroprotective effect of the formulation. Silymarin-loaded beads of Chitosan-MMT were found to exhibit good mucoadhesion and efficient release of the drug, and were found to be a promising drug carrier system for the treatment of gastric ulcers. MDPI 2018-09-10 /pmc/articles/PMC6164251/ /pubmed/30201932 http://dx.doi.org/10.3390/jfb9030052 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sharma, Ameya Puri, Vivek Kakkar, Vandita Singh, Inderbir Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers |
title | Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers |
title_full | Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers |
title_fullStr | Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers |
title_full_unstemmed | Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers |
title_short | Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers |
title_sort | formulation and evaluation of silymarin-loaded chitosan-montmorilloite microbeads for the potential treatment of gastric ulcers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164251/ https://www.ncbi.nlm.nih.gov/pubmed/30201932 http://dx.doi.org/10.3390/jfb9030052 |
work_keys_str_mv | AT sharmaameya formulationandevaluationofsilymarinloadedchitosanmontmorilloitemicrobeadsforthepotentialtreatmentofgastriculcers AT purivivek formulationandevaluationofsilymarinloadedchitosanmontmorilloitemicrobeadsforthepotentialtreatmentofgastriculcers AT kakkarvandita formulationandevaluationofsilymarinloadedchitosanmontmorilloitemicrobeadsforthepotentialtreatmentofgastriculcers AT singhinderbir formulationandevaluationofsilymarinloadedchitosanmontmorilloitemicrobeadsforthepotentialtreatmentofgastriculcers |