Role of Transglutaminase 2 in Migration of Tumor Cells and How Mouse Models Fit

A search for the “magic bullet”, a molecule, the targeting abilities of which could stop the migration of tumor cells, is currently underway, but remains in the early stages. There are still many unknowns regarding the cell migration. The main approach is the employment of mouse models, that are sou...

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Detalles Bibliográficos
Autor principal: Bihorac, Ajna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164270/
https://www.ncbi.nlm.nih.gov/pubmed/30200219
http://dx.doi.org/10.3390/medsci6030070
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author Bihorac, Ajna
author_facet Bihorac, Ajna
author_sort Bihorac, Ajna
collection PubMed
description A search for the “magic bullet”, a molecule, the targeting abilities of which could stop the migration of tumor cells, is currently underway, but remains in the early stages. There are still many unknowns regarding the cell migration. The main approach is the employment of mouse models, that are sources of valuable information, but still cannot answer all of the questions. One of the molecules of interest is Transglutaminase 2 (TG2). It is a well-described molecule involved in numerous pathways and elevated in metastatic tumors. The question remains whether mice and humans can give the same answer considering TG2.
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spelling pubmed-61642702018-10-10 Role of Transglutaminase 2 in Migration of Tumor Cells and How Mouse Models Fit Bihorac, Ajna Med Sci (Basel) Review A search for the “magic bullet”, a molecule, the targeting abilities of which could stop the migration of tumor cells, is currently underway, but remains in the early stages. There are still many unknowns regarding the cell migration. The main approach is the employment of mouse models, that are sources of valuable information, but still cannot answer all of the questions. One of the molecules of interest is Transglutaminase 2 (TG2). It is a well-described molecule involved in numerous pathways and elevated in metastatic tumors. The question remains whether mice and humans can give the same answer considering TG2. MDPI 2018-08-30 /pmc/articles/PMC6164270/ /pubmed/30200219 http://dx.doi.org/10.3390/medsci6030070 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bihorac, Ajna
Role of Transglutaminase 2 in Migration of Tumor Cells and How Mouse Models Fit
title Role of Transglutaminase 2 in Migration of Tumor Cells and How Mouse Models Fit
title_full Role of Transglutaminase 2 in Migration of Tumor Cells and How Mouse Models Fit
title_fullStr Role of Transglutaminase 2 in Migration of Tumor Cells and How Mouse Models Fit
title_full_unstemmed Role of Transglutaminase 2 in Migration of Tumor Cells and How Mouse Models Fit
title_short Role of Transglutaminase 2 in Migration of Tumor Cells and How Mouse Models Fit
title_sort role of transglutaminase 2 in migration of tumor cells and how mouse models fit
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164270/
https://www.ncbi.nlm.nih.gov/pubmed/30200219
http://dx.doi.org/10.3390/medsci6030070
work_keys_str_mv AT bihoracajna roleoftransglutaminase2inmigrationoftumorcellsandhowmousemodelsfit

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