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The Anti-Inflammatory Effects of Vitamin D in Tumorigenesis
In conjunction with the classical functions of regulating intestinal, bone, and kidney calcium and phosphorus absorption, as well as bone mineralization of vitamin D, the population-based association between low vitamin D status and increased cancer risk is now generally accepted. Inflammation is ca...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164284/ https://www.ncbi.nlm.nih.gov/pubmed/30216977 http://dx.doi.org/10.3390/ijms19092736 |
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author | Liu, Wei Zhang, Lei Xu, Hui-Jing Li, Yan Hu, Chuan-Min Yang, Jing-Yan Sun, Mei-Yan |
author_facet | Liu, Wei Zhang, Lei Xu, Hui-Jing Li, Yan Hu, Chuan-Min Yang, Jing-Yan Sun, Mei-Yan |
author_sort | Liu, Wei |
collection | PubMed |
description | In conjunction with the classical functions of regulating intestinal, bone, and kidney calcium and phosphorus absorption, as well as bone mineralization of vitamin D, the population-based association between low vitamin D status and increased cancer risk is now generally accepted. Inflammation is causally related to oncogenesis. It is widely thought that vitamin D plays an important role in the modulation of the inflammation system by regulating the production of inflammatory cytokines and immune cells, which are crucial for the pathogenesis of many immune-related diseases. Mechanistic studies have shown that vitamin D influences inflammatory processes involved in cancer progression, including cytokines, prostaglandins, MAP kinase phosphatase 5 (MKP5), the nuclear factor kappa B (NF-κB) pathway, and immune cells. Multiple studies have shown that vitamin D has the potential to inhibit tumor development by interfering with the inflammation system. The present review summarizes recent studies of the mechanisms of vitamin D on regulating the inflammation system, which contributes to its potential for cancer prevention and therapy. This review helps answer whether inflammation mediates a causal relationship between vitamin D and tumorigenesis. |
format | Online Article Text |
id | pubmed-6164284 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61642842018-10-10 The Anti-Inflammatory Effects of Vitamin D in Tumorigenesis Liu, Wei Zhang, Lei Xu, Hui-Jing Li, Yan Hu, Chuan-Min Yang, Jing-Yan Sun, Mei-Yan Int J Mol Sci Review In conjunction with the classical functions of regulating intestinal, bone, and kidney calcium and phosphorus absorption, as well as bone mineralization of vitamin D, the population-based association between low vitamin D status and increased cancer risk is now generally accepted. Inflammation is causally related to oncogenesis. It is widely thought that vitamin D plays an important role in the modulation of the inflammation system by regulating the production of inflammatory cytokines and immune cells, which are crucial for the pathogenesis of many immune-related diseases. Mechanistic studies have shown that vitamin D influences inflammatory processes involved in cancer progression, including cytokines, prostaglandins, MAP kinase phosphatase 5 (MKP5), the nuclear factor kappa B (NF-κB) pathway, and immune cells. Multiple studies have shown that vitamin D has the potential to inhibit tumor development by interfering with the inflammation system. The present review summarizes recent studies of the mechanisms of vitamin D on regulating the inflammation system, which contributes to its potential for cancer prevention and therapy. This review helps answer whether inflammation mediates a causal relationship between vitamin D and tumorigenesis. MDPI 2018-09-13 /pmc/articles/PMC6164284/ /pubmed/30216977 http://dx.doi.org/10.3390/ijms19092736 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liu, Wei Zhang, Lei Xu, Hui-Jing Li, Yan Hu, Chuan-Min Yang, Jing-Yan Sun, Mei-Yan The Anti-Inflammatory Effects of Vitamin D in Tumorigenesis |
title | The Anti-Inflammatory Effects of Vitamin D in Tumorigenesis |
title_full | The Anti-Inflammatory Effects of Vitamin D in Tumorigenesis |
title_fullStr | The Anti-Inflammatory Effects of Vitamin D in Tumorigenesis |
title_full_unstemmed | The Anti-Inflammatory Effects of Vitamin D in Tumorigenesis |
title_short | The Anti-Inflammatory Effects of Vitamin D in Tumorigenesis |
title_sort | anti-inflammatory effects of vitamin d in tumorigenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164284/ https://www.ncbi.nlm.nih.gov/pubmed/30216977 http://dx.doi.org/10.3390/ijms19092736 |
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