Advances in Imaging Specific Mediators of Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is characterized by chronic remitting and relapsing inflammation of the lower gastrointestinal tract. The etiology underlying IBD remains unknown, but it is thought to involve a hypersensitive immune response to environmental antigens, including the microbiota. Diagn...

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Detalles Bibliográficos
Autores principales: Dmochowska, Nicole, Wardill, Hannah R., Hughes, Patrick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164364/
https://www.ncbi.nlm.nih.gov/pubmed/30134572
http://dx.doi.org/10.3390/ijms19092471
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author Dmochowska, Nicole
Wardill, Hannah R.
Hughes, Patrick A.
author_facet Dmochowska, Nicole
Wardill, Hannah R.
Hughes, Patrick A.
author_sort Dmochowska, Nicole
collection PubMed
description Inflammatory bowel disease (IBD) is characterized by chronic remitting and relapsing inflammation of the lower gastrointestinal tract. The etiology underlying IBD remains unknown, but it is thought to involve a hypersensitive immune response to environmental antigens, including the microbiota. Diagnosis and monitoring of IBD is heavily reliant on endoscopy, which is invasive and does not provide information regarding specific mediators. This review describes recent developments in imaging of IBD with a focus on positron emission tomography (PET) and single-photon emission computed tomography (SPECT) of inflammatory mediators, and how these developments may be applied to the microbiota.
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spelling pubmed-61643642018-10-10 Advances in Imaging Specific Mediators of Inflammatory Bowel Disease Dmochowska, Nicole Wardill, Hannah R. Hughes, Patrick A. Int J Mol Sci Review Inflammatory bowel disease (IBD) is characterized by chronic remitting and relapsing inflammation of the lower gastrointestinal tract. The etiology underlying IBD remains unknown, but it is thought to involve a hypersensitive immune response to environmental antigens, including the microbiota. Diagnosis and monitoring of IBD is heavily reliant on endoscopy, which is invasive and does not provide information regarding specific mediators. This review describes recent developments in imaging of IBD with a focus on positron emission tomography (PET) and single-photon emission computed tomography (SPECT) of inflammatory mediators, and how these developments may be applied to the microbiota. MDPI 2018-08-21 /pmc/articles/PMC6164364/ /pubmed/30134572 http://dx.doi.org/10.3390/ijms19092471 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dmochowska, Nicole
Wardill, Hannah R.
Hughes, Patrick A.
Advances in Imaging Specific Mediators of Inflammatory Bowel Disease
title Advances in Imaging Specific Mediators of Inflammatory Bowel Disease
title_full Advances in Imaging Specific Mediators of Inflammatory Bowel Disease
title_fullStr Advances in Imaging Specific Mediators of Inflammatory Bowel Disease
title_full_unstemmed Advances in Imaging Specific Mediators of Inflammatory Bowel Disease
title_short Advances in Imaging Specific Mediators of Inflammatory Bowel Disease
title_sort advances in imaging specific mediators of inflammatory bowel disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164364/
https://www.ncbi.nlm.nih.gov/pubmed/30134572
http://dx.doi.org/10.3390/ijms19092471
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