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Marine Microalgae: Promising Source for New Bioactive Compounds
The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a biological and chemical diversity with metabolic abilities unrivalled in terrestrial systems, which makes them an attractive target for biopr...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164378/ https://www.ncbi.nlm.nih.gov/pubmed/30200664 http://dx.doi.org/10.3390/md16090317 |
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author | de Vera, Caterina R. Díaz Crespín, Guillermo Hernández Daranas, Antonio Montalvão Looga, Sofia Lillsunde, Katja-Emilia Tammela, Päivi Perälä, Merja Hongisto, Vesa Virtanen, Johannes Rischer, Heiko Muller, Christian D. Norte, Manuel Fernández, José J. Souto, María L. |
author_facet | de Vera, Caterina R. Díaz Crespín, Guillermo Hernández Daranas, Antonio Montalvão Looga, Sofia Lillsunde, Katja-Emilia Tammela, Päivi Perälä, Merja Hongisto, Vesa Virtanen, Johannes Rischer, Heiko Muller, Christian D. Norte, Manuel Fernández, José J. Souto, María L. |
author_sort | de Vera, Caterina R. |
collection | PubMed |
description | The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a biological and chemical diversity with metabolic abilities unrivalled in terrestrial systems, which makes them an attractive target for bioprospecting as an almost untapped resource of biotechnological applications. Among them, there is no doubt that microalgae could become genuine “cell factories” for the biological synthesis of bioactive substances. Thus, in the course of inter-laboratory collaboration sponsored by the European Union (7th FP) into the MAREX Project focused on the discovery of novel bioactive compounds of marine origin for the European industry, a bioprospecting study on 33 microalgae strains was carried out. The strains were cultured at laboratory scale. Two extracts were prepared for each one (biomass and cell free culture medium) and, thus, screened to provide information on the antimicrobial, the anti-proliferative, and the apoptotic potential of the studied extracts. The outcome of this study provides additional scientific data for the selection of Alexandrium tamarensis WE, Gambierdiscus australes, Prorocentrum arenarium, Prorocentrum hoffmannianum, and Prorocentrum reticulatum (Pr-3) for further investigation and offers support for the continued research of new potential drugs for human therapeutics from cultured microalgae. |
format | Online Article Text |
id | pubmed-6164378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61643782018-10-11 Marine Microalgae: Promising Source for New Bioactive Compounds de Vera, Caterina R. Díaz Crespín, Guillermo Hernández Daranas, Antonio Montalvão Looga, Sofia Lillsunde, Katja-Emilia Tammela, Päivi Perälä, Merja Hongisto, Vesa Virtanen, Johannes Rischer, Heiko Muller, Christian D. Norte, Manuel Fernández, José J. Souto, María L. Mar Drugs Article The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a biological and chemical diversity with metabolic abilities unrivalled in terrestrial systems, which makes them an attractive target for bioprospecting as an almost untapped resource of biotechnological applications. Among them, there is no doubt that microalgae could become genuine “cell factories” for the biological synthesis of bioactive substances. Thus, in the course of inter-laboratory collaboration sponsored by the European Union (7th FP) into the MAREX Project focused on the discovery of novel bioactive compounds of marine origin for the European industry, a bioprospecting study on 33 microalgae strains was carried out. The strains were cultured at laboratory scale. Two extracts were prepared for each one (biomass and cell free culture medium) and, thus, screened to provide information on the antimicrobial, the anti-proliferative, and the apoptotic potential of the studied extracts. The outcome of this study provides additional scientific data for the selection of Alexandrium tamarensis WE, Gambierdiscus australes, Prorocentrum arenarium, Prorocentrum hoffmannianum, and Prorocentrum reticulatum (Pr-3) for further investigation and offers support for the continued research of new potential drugs for human therapeutics from cultured microalgae. MDPI 2018-09-06 /pmc/articles/PMC6164378/ /pubmed/30200664 http://dx.doi.org/10.3390/md16090317 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article de Vera, Caterina R. Díaz Crespín, Guillermo Hernández Daranas, Antonio Montalvão Looga, Sofia Lillsunde, Katja-Emilia Tammela, Päivi Perälä, Merja Hongisto, Vesa Virtanen, Johannes Rischer, Heiko Muller, Christian D. Norte, Manuel Fernández, José J. Souto, María L. Marine Microalgae: Promising Source for New Bioactive Compounds |
title | Marine Microalgae: Promising Source for New Bioactive Compounds |
title_full | Marine Microalgae: Promising Source for New Bioactive Compounds |
title_fullStr | Marine Microalgae: Promising Source for New Bioactive Compounds |
title_full_unstemmed | Marine Microalgae: Promising Source for New Bioactive Compounds |
title_short | Marine Microalgae: Promising Source for New Bioactive Compounds |
title_sort | marine microalgae: promising source for new bioactive compounds |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164378/ https://www.ncbi.nlm.nih.gov/pubmed/30200664 http://dx.doi.org/10.3390/md16090317 |
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