Cargando…

Marine Microalgae: Promising Source for New Bioactive Compounds

The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a biological and chemical diversity with metabolic abilities unrivalled in terrestrial systems, which makes them an attractive target for biopr...

Descripción completa

Detalles Bibliográficos
Autores principales: de Vera, Caterina R., Díaz Crespín, Guillermo, Hernández Daranas, Antonio, Montalvão Looga, Sofia, Lillsunde, Katja-Emilia, Tammela, Päivi, Perälä, Merja, Hongisto, Vesa, Virtanen, Johannes, Rischer, Heiko, Muller, Christian D., Norte, Manuel, Fernández, José J., Souto, María L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164378/
https://www.ncbi.nlm.nih.gov/pubmed/30200664
http://dx.doi.org/10.3390/md16090317
_version_ 1783359585806974976
author de Vera, Caterina R.
Díaz Crespín, Guillermo
Hernández Daranas, Antonio
Montalvão Looga, Sofia
Lillsunde, Katja-Emilia
Tammela, Päivi
Perälä, Merja
Hongisto, Vesa
Virtanen, Johannes
Rischer, Heiko
Muller, Christian D.
Norte, Manuel
Fernández, José J.
Souto, María L.
author_facet de Vera, Caterina R.
Díaz Crespín, Guillermo
Hernández Daranas, Antonio
Montalvão Looga, Sofia
Lillsunde, Katja-Emilia
Tammela, Päivi
Perälä, Merja
Hongisto, Vesa
Virtanen, Johannes
Rischer, Heiko
Muller, Christian D.
Norte, Manuel
Fernández, José J.
Souto, María L.
author_sort de Vera, Caterina R.
collection PubMed
description The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a biological and chemical diversity with metabolic abilities unrivalled in terrestrial systems, which makes them an attractive target for bioprospecting as an almost untapped resource of biotechnological applications. Among them, there is no doubt that microalgae could become genuine “cell factories” for the biological synthesis of bioactive substances. Thus, in the course of inter-laboratory collaboration sponsored by the European Union (7th FP) into the MAREX Project focused on the discovery of novel bioactive compounds of marine origin for the European industry, a bioprospecting study on 33 microalgae strains was carried out. The strains were cultured at laboratory scale. Two extracts were prepared for each one (biomass and cell free culture medium) and, thus, screened to provide information on the antimicrobial, the anti-proliferative, and the apoptotic potential of the studied extracts. The outcome of this study provides additional scientific data for the selection of Alexandrium tamarensis WE, Gambierdiscus australes, Prorocentrum arenarium, Prorocentrum hoffmannianum, and Prorocentrum reticulatum (Pr-3) for further investigation and offers support for the continued research of new potential drugs for human therapeutics from cultured microalgae.
format Online
Article
Text
id pubmed-6164378
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-61643782018-10-11 Marine Microalgae: Promising Source for New Bioactive Compounds de Vera, Caterina R. Díaz Crespín, Guillermo Hernández Daranas, Antonio Montalvão Looga, Sofia Lillsunde, Katja-Emilia Tammela, Päivi Perälä, Merja Hongisto, Vesa Virtanen, Johannes Rischer, Heiko Muller, Christian D. Norte, Manuel Fernández, José J. Souto, María L. Mar Drugs Article The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a biological and chemical diversity with metabolic abilities unrivalled in terrestrial systems, which makes them an attractive target for bioprospecting as an almost untapped resource of biotechnological applications. Among them, there is no doubt that microalgae could become genuine “cell factories” for the biological synthesis of bioactive substances. Thus, in the course of inter-laboratory collaboration sponsored by the European Union (7th FP) into the MAREX Project focused on the discovery of novel bioactive compounds of marine origin for the European industry, a bioprospecting study on 33 microalgae strains was carried out. The strains were cultured at laboratory scale. Two extracts were prepared for each one (biomass and cell free culture medium) and, thus, screened to provide information on the antimicrobial, the anti-proliferative, and the apoptotic potential of the studied extracts. The outcome of this study provides additional scientific data for the selection of Alexandrium tamarensis WE, Gambierdiscus australes, Prorocentrum arenarium, Prorocentrum hoffmannianum, and Prorocentrum reticulatum (Pr-3) for further investigation and offers support for the continued research of new potential drugs for human therapeutics from cultured microalgae. MDPI 2018-09-06 /pmc/articles/PMC6164378/ /pubmed/30200664 http://dx.doi.org/10.3390/md16090317 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Vera, Caterina R.
Díaz Crespín, Guillermo
Hernández Daranas, Antonio
Montalvão Looga, Sofia
Lillsunde, Katja-Emilia
Tammela, Päivi
Perälä, Merja
Hongisto, Vesa
Virtanen, Johannes
Rischer, Heiko
Muller, Christian D.
Norte, Manuel
Fernández, José J.
Souto, María L.
Marine Microalgae: Promising Source for New Bioactive Compounds
title Marine Microalgae: Promising Source for New Bioactive Compounds
title_full Marine Microalgae: Promising Source for New Bioactive Compounds
title_fullStr Marine Microalgae: Promising Source for New Bioactive Compounds
title_full_unstemmed Marine Microalgae: Promising Source for New Bioactive Compounds
title_short Marine Microalgae: Promising Source for New Bioactive Compounds
title_sort marine microalgae: promising source for new bioactive compounds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164378/
https://www.ncbi.nlm.nih.gov/pubmed/30200664
http://dx.doi.org/10.3390/md16090317
work_keys_str_mv AT deveracaterinar marinemicroalgaepromisingsourcefornewbioactivecompounds
AT diazcrespinguillermo marinemicroalgaepromisingsourcefornewbioactivecompounds
AT hernandezdaranasantonio marinemicroalgaepromisingsourcefornewbioactivecompounds
AT montalvaoloogasofia marinemicroalgaepromisingsourcefornewbioactivecompounds
AT lillsundekatjaemilia marinemicroalgaepromisingsourcefornewbioactivecompounds
AT tammelapaivi marinemicroalgaepromisingsourcefornewbioactivecompounds
AT peralamerja marinemicroalgaepromisingsourcefornewbioactivecompounds
AT hongistovesa marinemicroalgaepromisingsourcefornewbioactivecompounds
AT virtanenjohannes marinemicroalgaepromisingsourcefornewbioactivecompounds
AT rischerheiko marinemicroalgaepromisingsourcefornewbioactivecompounds
AT mullerchristiand marinemicroalgaepromisingsourcefornewbioactivecompounds
AT nortemanuel marinemicroalgaepromisingsourcefornewbioactivecompounds
AT fernandezjosej marinemicroalgaepromisingsourcefornewbioactivecompounds
AT soutomarial marinemicroalgaepromisingsourcefornewbioactivecompounds