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Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines

(1) Background: Graphene oxide is a new carbon-based material that contains functional groups (carboxyl, hydroxyl, carbonyl, epoxy) and therefore can be easily functionalized with organic compounds of interest, yielding hybrid materials with important properties and applications. (2) Methods: Graphe...

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Autores principales: Zarafu, Irina, Turcu, Ioana, Culiță, Daniela C., Petrescu, Simona, Popa, Marcela, Chifiriuc, Mariana C., Limban, Carmen, Telehoiu, Alexandra, Ioniță, Petre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164380/
https://www.ncbi.nlm.nih.gov/pubmed/30217002
http://dx.doi.org/10.3390/ma11091704
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author Zarafu, Irina
Turcu, Ioana
Culiță, Daniela C.
Petrescu, Simona
Popa, Marcela
Chifiriuc, Mariana C.
Limban, Carmen
Telehoiu, Alexandra
Ioniță, Petre
author_facet Zarafu, Irina
Turcu, Ioana
Culiță, Daniela C.
Petrescu, Simona
Popa, Marcela
Chifiriuc, Mariana C.
Limban, Carmen
Telehoiu, Alexandra
Ioniță, Petre
author_sort Zarafu, Irina
collection PubMed
description (1) Background: Graphene oxide is a new carbon-based material that contains functional groups (carboxyl, hydroxyl, carbonyl, epoxy) and therefore can be easily functionalized with organic compounds of interest, yielding hybrid materials with important properties and applications. (2) Methods: Graphene oxide has been obtained by a modified Hummers method and activated by thionyl chloride in order to be covalently functionalized with amines. Thus obtained hybrid materials were characterized by infrared and Raman spectroscopy, elemental analysis and scanning electron microscopy and then tested for their antimicrobial and anti-biofilm activity. (3) Results: Eight amines of interest were used to functionalize grapheme oxide and the materials thus obtained were tested against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacterial strainsin plankonic and biofilm growth state. Both amines, as well as the functionalized materials, exhibited anti-microbial features. Three to five functionalized graphene oxide materials exhibited improved inhibitory activity against planktonic strains as compared with the respective amines. In exchange, the amines alone proved generally more efficient against biofilm-embedded cells. (4) Conclusions: Such hybrid materials may have a wide range of potential use in biomedical applications.
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spelling pubmed-61643802018-10-12 Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines Zarafu, Irina Turcu, Ioana Culiță, Daniela C. Petrescu, Simona Popa, Marcela Chifiriuc, Mariana C. Limban, Carmen Telehoiu, Alexandra Ioniță, Petre Materials (Basel) Article (1) Background: Graphene oxide is a new carbon-based material that contains functional groups (carboxyl, hydroxyl, carbonyl, epoxy) and therefore can be easily functionalized with organic compounds of interest, yielding hybrid materials with important properties and applications. (2) Methods: Graphene oxide has been obtained by a modified Hummers method and activated by thionyl chloride in order to be covalently functionalized with amines. Thus obtained hybrid materials were characterized by infrared and Raman spectroscopy, elemental analysis and scanning electron microscopy and then tested for their antimicrobial and anti-biofilm activity. (3) Results: Eight amines of interest were used to functionalize grapheme oxide and the materials thus obtained were tested against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacterial strainsin plankonic and biofilm growth state. Both amines, as well as the functionalized materials, exhibited anti-microbial features. Three to five functionalized graphene oxide materials exhibited improved inhibitory activity against planktonic strains as compared with the respective amines. In exchange, the amines alone proved generally more efficient against biofilm-embedded cells. (4) Conclusions: Such hybrid materials may have a wide range of potential use in biomedical applications. MDPI 2018-09-13 /pmc/articles/PMC6164380/ /pubmed/30217002 http://dx.doi.org/10.3390/ma11091704 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zarafu, Irina
Turcu, Ioana
Culiță, Daniela C.
Petrescu, Simona
Popa, Marcela
Chifiriuc, Mariana C.
Limban, Carmen
Telehoiu, Alexandra
Ioniță, Petre
Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines
title Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines
title_full Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines
title_fullStr Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines
title_full_unstemmed Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines
title_short Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines
title_sort antimicrobial features of organic functionalized graphene-oxide with selected amines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164380/
https://www.ncbi.nlm.nih.gov/pubmed/30217002
http://dx.doi.org/10.3390/ma11091704
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