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Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines
(1) Background: Graphene oxide is a new carbon-based material that contains functional groups (carboxyl, hydroxyl, carbonyl, epoxy) and therefore can be easily functionalized with organic compounds of interest, yielding hybrid materials with important properties and applications. (2) Methods: Graphe...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164380/ https://www.ncbi.nlm.nih.gov/pubmed/30217002 http://dx.doi.org/10.3390/ma11091704 |
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author | Zarafu, Irina Turcu, Ioana Culiță, Daniela C. Petrescu, Simona Popa, Marcela Chifiriuc, Mariana C. Limban, Carmen Telehoiu, Alexandra Ioniță, Petre |
author_facet | Zarafu, Irina Turcu, Ioana Culiță, Daniela C. Petrescu, Simona Popa, Marcela Chifiriuc, Mariana C. Limban, Carmen Telehoiu, Alexandra Ioniță, Petre |
author_sort | Zarafu, Irina |
collection | PubMed |
description | (1) Background: Graphene oxide is a new carbon-based material that contains functional groups (carboxyl, hydroxyl, carbonyl, epoxy) and therefore can be easily functionalized with organic compounds of interest, yielding hybrid materials with important properties and applications. (2) Methods: Graphene oxide has been obtained by a modified Hummers method and activated by thionyl chloride in order to be covalently functionalized with amines. Thus obtained hybrid materials were characterized by infrared and Raman spectroscopy, elemental analysis and scanning electron microscopy and then tested for their antimicrobial and anti-biofilm activity. (3) Results: Eight amines of interest were used to functionalize grapheme oxide and the materials thus obtained were tested against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacterial strainsin plankonic and biofilm growth state. Both amines, as well as the functionalized materials, exhibited anti-microbial features. Three to five functionalized graphene oxide materials exhibited improved inhibitory activity against planktonic strains as compared with the respective amines. In exchange, the amines alone proved generally more efficient against biofilm-embedded cells. (4) Conclusions: Such hybrid materials may have a wide range of potential use in biomedical applications. |
format | Online Article Text |
id | pubmed-6164380 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61643802018-10-12 Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines Zarafu, Irina Turcu, Ioana Culiță, Daniela C. Petrescu, Simona Popa, Marcela Chifiriuc, Mariana C. Limban, Carmen Telehoiu, Alexandra Ioniță, Petre Materials (Basel) Article (1) Background: Graphene oxide is a new carbon-based material that contains functional groups (carboxyl, hydroxyl, carbonyl, epoxy) and therefore can be easily functionalized with organic compounds of interest, yielding hybrid materials with important properties and applications. (2) Methods: Graphene oxide has been obtained by a modified Hummers method and activated by thionyl chloride in order to be covalently functionalized with amines. Thus obtained hybrid materials were characterized by infrared and Raman spectroscopy, elemental analysis and scanning electron microscopy and then tested for their antimicrobial and anti-biofilm activity. (3) Results: Eight amines of interest were used to functionalize grapheme oxide and the materials thus obtained were tested against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacterial strainsin plankonic and biofilm growth state. Both amines, as well as the functionalized materials, exhibited anti-microbial features. Three to five functionalized graphene oxide materials exhibited improved inhibitory activity against planktonic strains as compared with the respective amines. In exchange, the amines alone proved generally more efficient against biofilm-embedded cells. (4) Conclusions: Such hybrid materials may have a wide range of potential use in biomedical applications. MDPI 2018-09-13 /pmc/articles/PMC6164380/ /pubmed/30217002 http://dx.doi.org/10.3390/ma11091704 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zarafu, Irina Turcu, Ioana Culiță, Daniela C. Petrescu, Simona Popa, Marcela Chifiriuc, Mariana C. Limban, Carmen Telehoiu, Alexandra Ioniță, Petre Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines |
title | Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines |
title_full | Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines |
title_fullStr | Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines |
title_full_unstemmed | Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines |
title_short | Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines |
title_sort | antimicrobial features of organic functionalized graphene-oxide with selected amines |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164380/ https://www.ncbi.nlm.nih.gov/pubmed/30217002 http://dx.doi.org/10.3390/ma11091704 |
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