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Molecular Communication of a Dying Neuron in Stroke

When a main artery of the brain occludes, a cellular response involving multiple cell types follows. Cells directly affected by the lack of glucose and oxygen in the neuronal core die by necrosis. In the periphery surrounding the ischemic core (the so-called penumbra) neurons, astrocytes, microglia,...

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Detalles Bibliográficos
Autores principales: Puig, Berta, Brenna, Santra, Magnus, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164443/
https://www.ncbi.nlm.nih.gov/pubmed/30235837
http://dx.doi.org/10.3390/ijms19092834
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author Puig, Berta
Brenna, Santra
Magnus, Tim
author_facet Puig, Berta
Brenna, Santra
Magnus, Tim
author_sort Puig, Berta
collection PubMed
description When a main artery of the brain occludes, a cellular response involving multiple cell types follows. Cells directly affected by the lack of glucose and oxygen in the neuronal core die by necrosis. In the periphery surrounding the ischemic core (the so-called penumbra) neurons, astrocytes, microglia, oligodendrocytes, pericytes, and endothelial cells react to detrimental factors such as excitotoxicity, oxidative stress, and inflammation in different ways. The fate of the neurons in this area is multifactorial, and communication between all the players is important for survival. This review focuses on the latest research relating to synaptic loss and the release of apoptotic bodies and other extracellular vesicles for cellular communication in stroke. We also point out possible treatment options related to increasing neuronal survival and regeneration in the penumbra.
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spelling pubmed-61644432018-10-10 Molecular Communication of a Dying Neuron in Stroke Puig, Berta Brenna, Santra Magnus, Tim Int J Mol Sci Review When a main artery of the brain occludes, a cellular response involving multiple cell types follows. Cells directly affected by the lack of glucose and oxygen in the neuronal core die by necrosis. In the periphery surrounding the ischemic core (the so-called penumbra) neurons, astrocytes, microglia, oligodendrocytes, pericytes, and endothelial cells react to detrimental factors such as excitotoxicity, oxidative stress, and inflammation in different ways. The fate of the neurons in this area is multifactorial, and communication between all the players is important for survival. This review focuses on the latest research relating to synaptic loss and the release of apoptotic bodies and other extracellular vesicles for cellular communication in stroke. We also point out possible treatment options related to increasing neuronal survival and regeneration in the penumbra. MDPI 2018-09-19 /pmc/articles/PMC6164443/ /pubmed/30235837 http://dx.doi.org/10.3390/ijms19092834 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Puig, Berta
Brenna, Santra
Magnus, Tim
Molecular Communication of a Dying Neuron in Stroke
title Molecular Communication of a Dying Neuron in Stroke
title_full Molecular Communication of a Dying Neuron in Stroke
title_fullStr Molecular Communication of a Dying Neuron in Stroke
title_full_unstemmed Molecular Communication of a Dying Neuron in Stroke
title_short Molecular Communication of a Dying Neuron in Stroke
title_sort molecular communication of a dying neuron in stroke
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164443/
https://www.ncbi.nlm.nih.gov/pubmed/30235837
http://dx.doi.org/10.3390/ijms19092834
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