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Molecular Communication of a Dying Neuron in Stroke
When a main artery of the brain occludes, a cellular response involving multiple cell types follows. Cells directly affected by the lack of glucose and oxygen in the neuronal core die by necrosis. In the periphery surrounding the ischemic core (the so-called penumbra) neurons, astrocytes, microglia,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164443/ https://www.ncbi.nlm.nih.gov/pubmed/30235837 http://dx.doi.org/10.3390/ijms19092834 |
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author | Puig, Berta Brenna, Santra Magnus, Tim |
author_facet | Puig, Berta Brenna, Santra Magnus, Tim |
author_sort | Puig, Berta |
collection | PubMed |
description | When a main artery of the brain occludes, a cellular response involving multiple cell types follows. Cells directly affected by the lack of glucose and oxygen in the neuronal core die by necrosis. In the periphery surrounding the ischemic core (the so-called penumbra) neurons, astrocytes, microglia, oligodendrocytes, pericytes, and endothelial cells react to detrimental factors such as excitotoxicity, oxidative stress, and inflammation in different ways. The fate of the neurons in this area is multifactorial, and communication between all the players is important for survival. This review focuses on the latest research relating to synaptic loss and the release of apoptotic bodies and other extracellular vesicles for cellular communication in stroke. We also point out possible treatment options related to increasing neuronal survival and regeneration in the penumbra. |
format | Online Article Text |
id | pubmed-6164443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61644432018-10-10 Molecular Communication of a Dying Neuron in Stroke Puig, Berta Brenna, Santra Magnus, Tim Int J Mol Sci Review When a main artery of the brain occludes, a cellular response involving multiple cell types follows. Cells directly affected by the lack of glucose and oxygen in the neuronal core die by necrosis. In the periphery surrounding the ischemic core (the so-called penumbra) neurons, astrocytes, microglia, oligodendrocytes, pericytes, and endothelial cells react to detrimental factors such as excitotoxicity, oxidative stress, and inflammation in different ways. The fate of the neurons in this area is multifactorial, and communication between all the players is important for survival. This review focuses on the latest research relating to synaptic loss and the release of apoptotic bodies and other extracellular vesicles for cellular communication in stroke. We also point out possible treatment options related to increasing neuronal survival and regeneration in the penumbra. MDPI 2018-09-19 /pmc/articles/PMC6164443/ /pubmed/30235837 http://dx.doi.org/10.3390/ijms19092834 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Puig, Berta Brenna, Santra Magnus, Tim Molecular Communication of a Dying Neuron in Stroke |
title | Molecular Communication of a Dying Neuron in Stroke |
title_full | Molecular Communication of a Dying Neuron in Stroke |
title_fullStr | Molecular Communication of a Dying Neuron in Stroke |
title_full_unstemmed | Molecular Communication of a Dying Neuron in Stroke |
title_short | Molecular Communication of a Dying Neuron in Stroke |
title_sort | molecular communication of a dying neuron in stroke |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164443/ https://www.ncbi.nlm.nih.gov/pubmed/30235837 http://dx.doi.org/10.3390/ijms19092834 |
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