Transgenic Silkworm-Based Silk Gland Bioreactor for Large Scale Production of Bioactive Human Platelet-Derived Growth Factor (PDGF-BB) in Silk Cocoons

Human platelet derived growth factor (PDGF) is a major therapeutic protein with great demand in the clinical setting; however, its rate of supply is far from meeting needs. Here, we provide an effective strategy to produce PDGF-BB in large quantities using a transgenic silkworm. The codon-optimized...

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Detalles Bibliográficos
Autores principales: Chen, Wenjing, Wang, Feng, Tian, Chi, Wang, Yuancheng, Xu, Sheng, Wang, Riyuan, Hou, Kai, Zhao, Ping, Yu, Ling, Lu, Zhisong, Xia, Qingyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164493/
https://www.ncbi.nlm.nih.gov/pubmed/30150526
http://dx.doi.org/10.3390/ijms19092533

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