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Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease—First Report on the Prospective Relevance of Intrinsic Iron Release

Intrinsic iron release is discussed to have favorable effects in coronary artery disease (CAD). The aim of this study was to evaluate the prognostic relevance of intrinsic iron release in patients with CAD. Intrinsic iron release was based on a definition including hepcidin and soluble transferrin r...

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Autores principales: Ruhe, Julia, Waldeyer, Christoph, Ojeda, Francisco, Altay, Alev, Schnabel, Renate B., Schäfer, Sarina, Lackner, Karl J, Blankenberg, Stefan, Zeller, Tanja, Karakas, Mahir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164542/
https://www.ncbi.nlm.nih.gov/pubmed/30096922
http://dx.doi.org/10.3390/biom8030072
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author Ruhe, Julia
Waldeyer, Christoph
Ojeda, Francisco
Altay, Alev
Schnabel, Renate B.
Schäfer, Sarina
Lackner, Karl J
Blankenberg, Stefan
Zeller, Tanja
Karakas, Mahir
author_facet Ruhe, Julia
Waldeyer, Christoph
Ojeda, Francisco
Altay, Alev
Schnabel, Renate B.
Schäfer, Sarina
Lackner, Karl J
Blankenberg, Stefan
Zeller, Tanja
Karakas, Mahir
author_sort Ruhe, Julia
collection PubMed
description Intrinsic iron release is discussed to have favorable effects in coronary artery disease (CAD). The aim of this study was to evaluate the prognostic relevance of intrinsic iron release in patients with CAD. Intrinsic iron release was based on a definition including hepcidin and soluble transferrin receptor (sTfR). In a cohort of 811 patients with angiographically documented CAD levels of hepcidin and sTfR were measured at baseline. Systemic body iron release was defined as low levels of hepcidin (<24 ng/mL) and high levels of sTfR (≥2 mg/L). A commercially available ELISA (DRG) was used for measurements of serum hepcidin. Serum sTfR was determined by using an automated immunoassay (). Cardiovascular mortality was the main outcome measure. The criteria of intrinsic iron release were fulfilled in 32.6% of all patients. Significantly lower cardiovascular mortality rates were observed in CAD patients with systemic iron release. After adjustment for body mass index, smoking status, hypertension, diabetes, dyslipidemia, sex, and age, the hazard ratio for future cardiovascular death was 0.41. After an additional adjustment for surrogates of the size of myocardial necrosis (troponin I), anemia (hemoglobin), and cardiac function and heart failure severity (N-terminal pro B-type natriuretic peptide), this association did not change (Hazard ratio 0.37 (95% confidence interval 0.14–0.99), p = 0.047). In conclusion, significantly lower cardiovascular mortality rates were observed in CAD patients with intrinsic iron release shown during follow-up.
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spelling pubmed-61645422018-10-10 Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease—First Report on the Prospective Relevance of Intrinsic Iron Release Ruhe, Julia Waldeyer, Christoph Ojeda, Francisco Altay, Alev Schnabel, Renate B. Schäfer, Sarina Lackner, Karl J Blankenberg, Stefan Zeller, Tanja Karakas, Mahir Biomolecules Article Intrinsic iron release is discussed to have favorable effects in coronary artery disease (CAD). The aim of this study was to evaluate the prognostic relevance of intrinsic iron release in patients with CAD. Intrinsic iron release was based on a definition including hepcidin and soluble transferrin receptor (sTfR). In a cohort of 811 patients with angiographically documented CAD levels of hepcidin and sTfR were measured at baseline. Systemic body iron release was defined as low levels of hepcidin (<24 ng/mL) and high levels of sTfR (≥2 mg/L). A commercially available ELISA (DRG) was used for measurements of serum hepcidin. Serum sTfR was determined by using an automated immunoassay (). Cardiovascular mortality was the main outcome measure. The criteria of intrinsic iron release were fulfilled in 32.6% of all patients. Significantly lower cardiovascular mortality rates were observed in CAD patients with systemic iron release. After adjustment for body mass index, smoking status, hypertension, diabetes, dyslipidemia, sex, and age, the hazard ratio for future cardiovascular death was 0.41. After an additional adjustment for surrogates of the size of myocardial necrosis (troponin I), anemia (hemoglobin), and cardiac function and heart failure severity (N-terminal pro B-type natriuretic peptide), this association did not change (Hazard ratio 0.37 (95% confidence interval 0.14–0.99), p = 0.047). In conclusion, significantly lower cardiovascular mortality rates were observed in CAD patients with intrinsic iron release shown during follow-up. MDPI 2018-08-09 /pmc/articles/PMC6164542/ /pubmed/30096922 http://dx.doi.org/10.3390/biom8030072 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ruhe, Julia
Waldeyer, Christoph
Ojeda, Francisco
Altay, Alev
Schnabel, Renate B.
Schäfer, Sarina
Lackner, Karl J
Blankenberg, Stefan
Zeller, Tanja
Karakas, Mahir
Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease—First Report on the Prospective Relevance of Intrinsic Iron Release
title Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease—First Report on the Prospective Relevance of Intrinsic Iron Release
title_full Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease—First Report on the Prospective Relevance of Intrinsic Iron Release
title_fullStr Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease—First Report on the Prospective Relevance of Intrinsic Iron Release
title_full_unstemmed Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease—First Report on the Prospective Relevance of Intrinsic Iron Release
title_short Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease—First Report on the Prospective Relevance of Intrinsic Iron Release
title_sort intrinsic iron release is associated with lower mortality in patients with stable coronary artery disease—first report on the prospective relevance of intrinsic iron release
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164542/
https://www.ncbi.nlm.nih.gov/pubmed/30096922
http://dx.doi.org/10.3390/biom8030072
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