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The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas

Neuron glial antigen 2 (NG2) is a chondroitin sulphate proteoglycan 4 (CSPG4) that occurs in developing and adult central nervous systems (CNSs) as a marker of oligodendrocyte precursor cells (OPCs) together with platelet-derived growth factor receptor α (PDGFRα). It behaves variably in different pa...

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Autores principales: Schiffer, Davide, Mellai, Marta, Boldorini, Renzo, Bisogno, Ilaria, Grifoni, Silvia, Corona, Cristiano, Bertero, Luca, Cassoni, Paola, Casalone, Cristina, Annovazzi, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164575/
https://www.ncbi.nlm.nih.gov/pubmed/30213051
http://dx.doi.org/10.3390/ijms19092724
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author Schiffer, Davide
Mellai, Marta
Boldorini, Renzo
Bisogno, Ilaria
Grifoni, Silvia
Corona, Cristiano
Bertero, Luca
Cassoni, Paola
Casalone, Cristina
Annovazzi, Laura
author_facet Schiffer, Davide
Mellai, Marta
Boldorini, Renzo
Bisogno, Ilaria
Grifoni, Silvia
Corona, Cristiano
Bertero, Luca
Cassoni, Paola
Casalone, Cristina
Annovazzi, Laura
author_sort Schiffer, Davide
collection PubMed
description Neuron glial antigen 2 (NG2) is a chondroitin sulphate proteoglycan 4 (CSPG4) that occurs in developing and adult central nervous systems (CNSs) as a marker of oligodendrocyte precursor cells (OPCs) together with platelet-derived growth factor receptor α (PDGFRα). It behaves variably in different pathological conditions, and is possibly involved in the origin and progression of human gliomas. In the latter, NG2/CSPG4 induces cell proliferation and migration, is highly expressed in pericytes, and plays a role in neoangiogenesis. NG2/CSPG4 expression has been demonstrated in oligodendrogliomas, astrocytomas, and glioblastomas (GB), and it correlates with malignancy. In rat tumors transplacentally induced by N-ethyl-N-nitrosourea (ENU), NG2/CSPG4 expression correlates with PDGFRα, Olig2, Sox10, and Nkx2.2, and with new vessel formation. In this review, we attempt to summarize the normal and pathogenic functions of NG2/CSPG4, as well as its potential as a therapeutic target.
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spelling pubmed-61645752018-10-10 The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas Schiffer, Davide Mellai, Marta Boldorini, Renzo Bisogno, Ilaria Grifoni, Silvia Corona, Cristiano Bertero, Luca Cassoni, Paola Casalone, Cristina Annovazzi, Laura Int J Mol Sci Review Neuron glial antigen 2 (NG2) is a chondroitin sulphate proteoglycan 4 (CSPG4) that occurs in developing and adult central nervous systems (CNSs) as a marker of oligodendrocyte precursor cells (OPCs) together with platelet-derived growth factor receptor α (PDGFRα). It behaves variably in different pathological conditions, and is possibly involved in the origin and progression of human gliomas. In the latter, NG2/CSPG4 induces cell proliferation and migration, is highly expressed in pericytes, and plays a role in neoangiogenesis. NG2/CSPG4 expression has been demonstrated in oligodendrogliomas, astrocytomas, and glioblastomas (GB), and it correlates with malignancy. In rat tumors transplacentally induced by N-ethyl-N-nitrosourea (ENU), NG2/CSPG4 expression correlates with PDGFRα, Olig2, Sox10, and Nkx2.2, and with new vessel formation. In this review, we attempt to summarize the normal and pathogenic functions of NG2/CSPG4, as well as its potential as a therapeutic target. MDPI 2018-09-12 /pmc/articles/PMC6164575/ /pubmed/30213051 http://dx.doi.org/10.3390/ijms19092724 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schiffer, Davide
Mellai, Marta
Boldorini, Renzo
Bisogno, Ilaria
Grifoni, Silvia
Corona, Cristiano
Bertero, Luca
Cassoni, Paola
Casalone, Cristina
Annovazzi, Laura
The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas
title The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas
title_full The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas
title_fullStr The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas
title_full_unstemmed The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas
title_short The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas
title_sort significance of chondroitin sulfate proteoglycan 4 (cspg4) in human gliomas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164575/
https://www.ncbi.nlm.nih.gov/pubmed/30213051
http://dx.doi.org/10.3390/ijms19092724
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