Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin

The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.

Detalles Bibliográficos
Autores principales: Ye, Baijun, Jiang, Peng, Zhang, Tingrong, Sun, Yuanjun, Hao, Xin, Cui, Yingjun, Wang, Liang, Chen, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164609/
https://www.ncbi.nlm.nih.gov/pubmed/30227592
http://dx.doi.org/10.3390/md16090338
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author Ye, Baijun
Jiang, Peng
Zhang, Tingrong
Sun, Yuanjun
Hao, Xin
Cui, Yingjun
Wang, Liang
Chen, Yue
author_facet Ye, Baijun
Jiang, Peng
Zhang, Tingrong
Sun, Yuanjun
Hao, Xin
Cui, Yingjun
Wang, Liang
Chen, Yue
author_sort Ye, Baijun
collection PubMed
description The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.
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spelling pubmed-61646092018-10-11 Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin Ye, Baijun Jiang, Peng Zhang, Tingrong Sun, Yuanjun Hao, Xin Cui, Yingjun Wang, Liang Chen, Yue Mar Drugs Communication The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment. MDPI 2018-09-17 /pmc/articles/PMC6164609/ /pubmed/30227592 http://dx.doi.org/10.3390/md16090338 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Ye, Baijun
Jiang, Peng
Zhang, Tingrong
Sun, Yuanjun
Hao, Xin
Cui, Yingjun
Wang, Liang
Chen, Yue
Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin
title Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin
title_full Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin
title_fullStr Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin
title_full_unstemmed Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin
title_short Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin
title_sort total synthesis of the highly n-methylated peptides carmabin a and dragomabin
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164609/
https://www.ncbi.nlm.nih.gov/pubmed/30227592
http://dx.doi.org/10.3390/md16090338
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