Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin

The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.

Detalles Bibliográficos
Autores principales: Ye, Baijun, Jiang, Peng, Zhang, Tingrong, Sun, Yuanjun, Hao, Xin, Cui, Yingjun, Wang, Liang, Chen, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164609/
https://www.ncbi.nlm.nih.gov/pubmed/30227592
http://dx.doi.org/10.3390/md16090338

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