Cargando…

Platycodon grandiflorum Saponins Ameliorate Cisplatin-Induced Acute Nephrotoxicity through the NF-κB-Mediated Inflammation and PI3K/Akt/Apoptosis Signaling Pathways

Although cisplatin is a potent chemotherapeutic agent against cancers, its clinical application is seriously limited by its severe side effects of nephrotoxicity. Previous studies reported that saponins isolated from the roots of Platycodon grandiflorum (PGS) exerted protective effects in various an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Weizhe, Hou, Jingang, Yan, Xiaotong, Leng, Jing, Li, Rongyan, Zhang, Jing, Xing, Jingjing, Chen, Chen, Wang, Zi, Li, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164643/ https://www.ncbi.nlm.nih.gov/pubmed/30235825 http://dx.doi.org/10.3390/nu10091328

Ejemplares similares

Platycoside N: A New Oleanane-Type Triterpenoid Saponin from the Roots of Platycodon grandiflorum
por: Li, Wei, et al.
Publicado: (2010)

Platycodon saponins from Platycodi Radix (Platycodon grandiflorum) for the Green Synthesis of Gold and Silver Nanoparticles
por: Choi, Yoonho, et al.
Publicado: (2018)

Platycoside O, a New Triterpenoid Saponin from the Roots of Platycodon grandiflorum
por: Fu, Wen-Wei, et al.
Publicado: (2011)

Candidate Genes Involved in the Biosynthesis of Triterpenoid Saponins in Platycodon grandiflorum Identified by Transcriptome Analysis
por: Ma, Chun-Hua, et al.
Publicado: (2016)

Microbial conversion of major ginsenosides in ginseng total saponins by Platycodon grandiflorum endophytes
por: Cui, Lei, et al.
Publicado: (2016)

Evaluation of the Spermicidal and Contraceptive Activity of Platycodin D, a Saponin from Platycodon grandiflorum
por: Lu, Zongliang, et al.
Publicado: (2013)

Triterpenoid Saponins Isolated from Platycodon grandiflorum Inhibit Hepatitis C Virus Replication
por: Kim, Jong-Woo, et al.
Publicado: (2013)

Platyconic Acid A, a Genuine Triterpenoid Saponin from the Roots of Platycodon grandiflorum
por: Choi, Yeon Hee, et al.
Publicado: (2008)

Chromosome-Scale Genome Assembly and Triterpenoid Saponin Biosynthesis in Korean Bellflower (Platycodon grandiflorum)
por: Lee, Dong-Jun, et al.
Publicado: (2023)

Characterization of Saponins from Various Parts of Platycodon grandiflorum Using UPLC-QToF/MS
por: Lee, So-Jeong, et al.
Publicado: (2021)

A novel saponin liposomes based on the couplet medicines of Platycodon grandiflorum–Glycyrrhiza uralensis for targeting lung cancer
por: Guo, Chunjing, et al.
Publicado: (2022)

Platycosides from the Roots of Platycodon grandiflorum and Their Health Benefits
por: Nyakudya, Elijah, et al.
Publicado: (2014)

Chemical Characteristics of Platycodon grandiflorum and its Mechanism in Lung Cancer Treatment
por: Deng, Yaling, et al.
Publicado: (2021)

Exploration of Root-associated Bacteria from the Medicinal Plant Platycodon grandiflorum
por: Huang, Cong-Min, et al.
Publicado: (2019)

Optimization of ultrasonic-assisted extraction of Platycodon grandiflorum polysaccharides and evalution of its structural, antioxidant and hypoglycemic activity
por: Li, Wei, et al.
Publicado: (2023)

Platycodon grandiflorum extract: chemical composition and whitening, antioxidant, and anti-inflammatory effects
por: Ma, Xintong, et al.
Publicado: (2021)

Global Profiling of Various Metabolites in Platycodon grandiflorum by UPLC-QTOF/MS
por: Lee, Jae Won, et al.
Publicado: (2015)

Effects of Polysaccharides from Platycodon grandiflorum on Immunity-Enhancing Activity In Vitro
por: Zhao, Xiaona, et al.
Publicado: (2017)

accD nuclear transfer of Platycodon grandiflorum and the plastid of early Campanulaceae
por: Hong, Chang Pyo, et al.
Publicado: (2017)

Phenolic Constituents from Platycodon grandiflorum Root and Their Anti-Inflammatory Activity
por: Li, Wei, et al.
Publicado: (2021)

Polyacylated Anthocyanins in Bluish-Purple Petals of Chinese Bellflower, Platycodon grandiflorum
por: Kondo, Tadao, et al.
Publicado: (2021)

Effects of Platycodon grandiflorum on Gut Microbiome and Immune System of Immunosuppressed Mouse
por: Jhang, So-Yun, et al.
Publicado: (2021)

Extract of Platycodon grandiflorum Prevents Doxorubicin-induced Cardiotoxicity in Breast Cancer
por: Shi, Youyang, et al.
Publicado: (2023)

Crude Saponin from Platycodon grandiflorum Attenuates Aβ-Induced Neurotoxicity via Antioxidant, Anti-Inflammatory and Anti-Apoptotic Signaling Pathways
por: Ji, Yun-Jeong, et al.
Publicado: (2021)

Platycodon grandiflorum Protects Against Anthracycline-Induced Cardiotoxicity in Early Breast Cancer Patients
por: Hao, Wei, et al.
Publicado: (2020)

Nontargeted Metabolomic Analysis of Four Different Parts of Platycodon grandiflorum Grown in Northeast China
por: Wang, Cuizhu, et al.
Publicado: (2017)

Immunomodulatory effects of fermented Platycodon grandiflorum extract through NF-κB signaling in RAW 264.7 cells
por: Park, Eun-Jung, et al.
Publicado: (2020)

Quality control of Platycodon grandiflorum (Jacq.) A. DC. based on value chains and food chain analysis
por: Jiang, Linlin, et al.
Publicado: (2023)

Root Rot of Balloon Flower (Platycodon grandiflorum) Caused by Fusarium solani and Fusarium oxysporum
por: Jeon, Chi Sung, et al.
Publicado: (2013)

Effects of neutral polysaccharide from Platycodon grandiflorum on high-fat diet-induced obesity via the regulation of gut microbiota and metabolites
por: Song, Jing, et al.
Publicado: (2023)

Protective Effects of Platycodon grandiflorum Aqueous Extract on Thioacetamide-induced Fulminant Hepatic Failure in Mice
por: Lim, Jong-Hwan, et al.
Publicado: (2011)

A Systems-Level Analysis of Mechanisms of Platycodon grandiflorum Based on A Network Pharmacological Approach
por: Park, Musun, et al.
Publicado: (2018)

Improvement of loperamide-hydrochloride-induced intestinal motility disturbance by Platycodon grandiflorum polysaccharides through effects on gut microbes and colonic serotonin
por: Hao, Mengqi, et al.
Publicado: (2023)

Immuno-enhancement effects of Platycodon grandiflorum extracts in splenocytes and a cyclophosphamide-induced immunosuppressed rat model
por: Noh, Eun-Mi, et al.
Publicado: (2019)

Comparative Characterization and Immunomodulatory Activities of Polysaccharides Extracted from the Radix of Platycodon grandiflorum with Different Extraction Methods
por: Xiao, Wanwan, et al.
Publicado: (2022)

Optimization of extraction condition for platycodin D from Platycodon grandiflorum root and verification of its biological activity
por: Jung, Jihyeon, et al.
Publicado: (2023)

Immunostimulatory activity of hydrolyzed and fermented Platycodon grandiflorum extract occurs via the MAPK and NF-κB signaling pathway in RAW 264.7 cells
por: Jung, Jae In, et al.
Publicado: (2022)

Platycodin D, a bioactive component of Platycodon grandiflorum, induces cancer cell death associated with extreme vacuolation
por: Jeon, Daun, et al.
Publicado: (2019)

The Effect of Different Water Extracts from Platycodon grandiflorum on Selected Factors Associated with Pathogenesis of Chronic Bronchitis in Rats
por: Buchwald, Waldemar, et al.
Publicado: (2020)

Immune-enhancing effect of hydrolyzed and fermented Platycodon grandiflorum extract in cyclophosphamide-induced immunosuppressed BALB/c mice
por: Lee, Hyun Sook, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2p8mp7kkn5o8gvln0qe008rca6