Bacillamidins A–G from a Marine-Derived Bacillus pumilus

Seven long-chain amides, including five previously undescribed bacillamidins A–E (1–5) and two previously reported synthetic analogs, bacillamidins F (6) and G (7), were isolated from extracts of the marine-derived Bacillus pumilus strain RJA1515. The structures of the new compounds were established...

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Autores principales: Zhou, Si-Yu, Hu, Yi-Jie, Meng, Fan-Cheng, Qu, Shen-Yue, Wang, Rui, Andersen, Raymond J., Liao, Zhi-Hua, Chen, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164710/
https://www.ncbi.nlm.nih.gov/pubmed/30208577
http://dx.doi.org/10.3390/md16090326
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author Zhou, Si-Yu
Hu, Yi-Jie
Meng, Fan-Cheng
Qu, Shen-Yue
Wang, Rui
Andersen, Raymond J.
Liao, Zhi-Hua
Chen, Min
author_facet Zhou, Si-Yu
Hu, Yi-Jie
Meng, Fan-Cheng
Qu, Shen-Yue
Wang, Rui
Andersen, Raymond J.
Liao, Zhi-Hua
Chen, Min
author_sort Zhou, Si-Yu
collection PubMed
description Seven long-chain amides, including five previously undescribed bacillamidins A–E (1–5) and two previously reported synthetic analogs, bacillamidins F (6) and G (7), were isolated from extracts of the marine-derived Bacillus pumilus strain RJA1515. The structures of the new compounds were established by extensive analysis of 1D and 2D nuclear magnetic resonance (NMR) data as well as high resolution mass spectrometry (HRMS), and the absolute configurations of the stereogenic carbons of 1–4 were established by comparison of the calculated and the experimental electronic circular dichroism (ECD) spectra. The cytotoxic and antimicrobial activities of 1–7 were evaluated.
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spelling pubmed-61647102018-10-11 Bacillamidins A–G from a Marine-Derived Bacillus pumilus Zhou, Si-Yu Hu, Yi-Jie Meng, Fan-Cheng Qu, Shen-Yue Wang, Rui Andersen, Raymond J. Liao, Zhi-Hua Chen, Min Mar Drugs Article Seven long-chain amides, including five previously undescribed bacillamidins A–E (1–5) and two previously reported synthetic analogs, bacillamidins F (6) and G (7), were isolated from extracts of the marine-derived Bacillus pumilus strain RJA1515. The structures of the new compounds were established by extensive analysis of 1D and 2D nuclear magnetic resonance (NMR) data as well as high resolution mass spectrometry (HRMS), and the absolute configurations of the stereogenic carbons of 1–4 were established by comparison of the calculated and the experimental electronic circular dichroism (ECD) spectra. The cytotoxic and antimicrobial activities of 1–7 were evaluated. MDPI 2018-09-11 /pmc/articles/PMC6164710/ /pubmed/30208577 http://dx.doi.org/10.3390/md16090326 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhou, Si-Yu
Hu, Yi-Jie
Meng, Fan-Cheng
Qu, Shen-Yue
Wang, Rui
Andersen, Raymond J.
Liao, Zhi-Hua
Chen, Min
Bacillamidins A–G from a Marine-Derived Bacillus pumilus
title Bacillamidins A–G from a Marine-Derived Bacillus pumilus
title_full Bacillamidins A–G from a Marine-Derived Bacillus pumilus
title_fullStr Bacillamidins A–G from a Marine-Derived Bacillus pumilus
title_full_unstemmed Bacillamidins A–G from a Marine-Derived Bacillus pumilus
title_short Bacillamidins A–G from a Marine-Derived Bacillus pumilus
title_sort bacillamidins a–g from a marine-derived bacillus pumilus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164710/
https://www.ncbi.nlm.nih.gov/pubmed/30208577
http://dx.doi.org/10.3390/md16090326
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