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Neurocognitive and Psychosocial Outcomes in Pediatric Brain Tumor Survivors

The late neurocognitive and psychosocial effects of treatment for pediatric brain tumor (PBT) represent important areas of clinical focus and ongoing research. Neurocognitive sequelae and associated problems with learning and socioemotional development negatively impact PBT survivors’ overall health...

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Autores principales: Stavinoha, Peter L., Askins, Martha A., Powell, Stephanie K., Pillay Smiley, Natasha, Robert, Rhonda S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164803/
https://www.ncbi.nlm.nih.gov/pubmed/30208602
http://dx.doi.org/10.3390/bioengineering5030073
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author Stavinoha, Peter L.
Askins, Martha A.
Powell, Stephanie K.
Pillay Smiley, Natasha
Robert, Rhonda S.
author_facet Stavinoha, Peter L.
Askins, Martha A.
Powell, Stephanie K.
Pillay Smiley, Natasha
Robert, Rhonda S.
author_sort Stavinoha, Peter L.
collection PubMed
description The late neurocognitive and psychosocial effects of treatment for pediatric brain tumor (PBT) represent important areas of clinical focus and ongoing research. Neurocognitive sequelae and associated problems with learning and socioemotional development negatively impact PBT survivors’ overall health-related quality of life, educational attainment and employment rates. Multiple factors including tumor features and associated complications, treatment methods, individual protective and vulnerability factors and accessibility of environmental supports contribute to the neurocognitive and psychosocial outcomes in PBT survivors. Declines in overall measured intelligence are common and may persist years after treatment. Core deficits in attention, processing speed and working memory are postulated to underlie problems with overall intellectual development, academic achievement and career attainment. Additionally, psychological problems after PBT can include depression, anxiety and psychosocial adjustment issues. Several intervention paradigms are briefly described, though to date research on innovative, specific and effective interventions for neurocognitive late effects is still in its early stages. This article reviews the existing research for understanding PBT late effects and highlights the need for innovative research to enhance neurocognitive and psychosocial outcomes in PBT survivors.
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spelling pubmed-61648032018-10-11 Neurocognitive and Psychosocial Outcomes in Pediatric Brain Tumor Survivors Stavinoha, Peter L. Askins, Martha A. Powell, Stephanie K. Pillay Smiley, Natasha Robert, Rhonda S. Bioengineering (Basel) Review The late neurocognitive and psychosocial effects of treatment for pediatric brain tumor (PBT) represent important areas of clinical focus and ongoing research. Neurocognitive sequelae and associated problems with learning and socioemotional development negatively impact PBT survivors’ overall health-related quality of life, educational attainment and employment rates. Multiple factors including tumor features and associated complications, treatment methods, individual protective and vulnerability factors and accessibility of environmental supports contribute to the neurocognitive and psychosocial outcomes in PBT survivors. Declines in overall measured intelligence are common and may persist years after treatment. Core deficits in attention, processing speed and working memory are postulated to underlie problems with overall intellectual development, academic achievement and career attainment. Additionally, psychological problems after PBT can include depression, anxiety and psychosocial adjustment issues. Several intervention paradigms are briefly described, though to date research on innovative, specific and effective interventions for neurocognitive late effects is still in its early stages. This article reviews the existing research for understanding PBT late effects and highlights the need for innovative research to enhance neurocognitive and psychosocial outcomes in PBT survivors. MDPI 2018-09-11 /pmc/articles/PMC6164803/ /pubmed/30208602 http://dx.doi.org/10.3390/bioengineering5030073 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Stavinoha, Peter L.
Askins, Martha A.
Powell, Stephanie K.
Pillay Smiley, Natasha
Robert, Rhonda S.
Neurocognitive and Psychosocial Outcomes in Pediatric Brain Tumor Survivors
title Neurocognitive and Psychosocial Outcomes in Pediatric Brain Tumor Survivors
title_full Neurocognitive and Psychosocial Outcomes in Pediatric Brain Tumor Survivors
title_fullStr Neurocognitive and Psychosocial Outcomes in Pediatric Brain Tumor Survivors
title_full_unstemmed Neurocognitive and Psychosocial Outcomes in Pediatric Brain Tumor Survivors
title_short Neurocognitive and Psychosocial Outcomes in Pediatric Brain Tumor Survivors
title_sort neurocognitive and psychosocial outcomes in pediatric brain tumor survivors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164803/
https://www.ncbi.nlm.nih.gov/pubmed/30208602
http://dx.doi.org/10.3390/bioengineering5030073
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