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Susceptibility Genes to Plant Viruses

Plant viruses use cellular factors and resources to replicate and move. Plants respond to viral infection by several mechanisms, including innate immunity, autophagy, and gene silencing, that viruses must evade or suppress. Thus, the establishment of infection is genetically determined by the availa...

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Detalles Bibliográficos
Autor principal: Garcia-Ruiz, Hernan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164914/
https://www.ncbi.nlm.nih.gov/pubmed/30201857
http://dx.doi.org/10.3390/v10090484
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author Garcia-Ruiz, Hernan
author_facet Garcia-Ruiz, Hernan
author_sort Garcia-Ruiz, Hernan
collection PubMed
description Plant viruses use cellular factors and resources to replicate and move. Plants respond to viral infection by several mechanisms, including innate immunity, autophagy, and gene silencing, that viruses must evade or suppress. Thus, the establishment of infection is genetically determined by the availability of host factors necessary for virus replication and movement and by the balance between plant defense and viral suppression of defense responses. Host factors may have antiviral or proviral activities. Proviral factors condition susceptibility to viruses by participating in processes essential to the virus. Here, we review current advances in the identification and characterization of host factors that condition susceptibility to plant viruses. Host factors with proviral activity have been identified for all parts of the virus infection cycle: viral RNA translation, viral replication complex formation, accumulation or activity of virus replication proteins, virus movement, and virion assembly. These factors could be targets of gene editing to engineer resistance to plant viruses.
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spelling pubmed-61649142018-10-11 Susceptibility Genes to Plant Viruses Garcia-Ruiz, Hernan Viruses Review Plant viruses use cellular factors and resources to replicate and move. Plants respond to viral infection by several mechanisms, including innate immunity, autophagy, and gene silencing, that viruses must evade or suppress. Thus, the establishment of infection is genetically determined by the availability of host factors necessary for virus replication and movement and by the balance between plant defense and viral suppression of defense responses. Host factors may have antiviral or proviral activities. Proviral factors condition susceptibility to viruses by participating in processes essential to the virus. Here, we review current advances in the identification and characterization of host factors that condition susceptibility to plant viruses. Host factors with proviral activity have been identified for all parts of the virus infection cycle: viral RNA translation, viral replication complex formation, accumulation or activity of virus replication proteins, virus movement, and virion assembly. These factors could be targets of gene editing to engineer resistance to plant viruses. MDPI 2018-09-10 /pmc/articles/PMC6164914/ /pubmed/30201857 http://dx.doi.org/10.3390/v10090484 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Garcia-Ruiz, Hernan
Susceptibility Genes to Plant Viruses
title Susceptibility Genes to Plant Viruses
title_full Susceptibility Genes to Plant Viruses
title_fullStr Susceptibility Genes to Plant Viruses
title_full_unstemmed Susceptibility Genes to Plant Viruses
title_short Susceptibility Genes to Plant Viruses
title_sort susceptibility genes to plant viruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164914/
https://www.ncbi.nlm.nih.gov/pubmed/30201857
http://dx.doi.org/10.3390/v10090484
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