Cargando…
Susceptibility Genes to Plant Viruses
Plant viruses use cellular factors and resources to replicate and move. Plants respond to viral infection by several mechanisms, including innate immunity, autophagy, and gene silencing, that viruses must evade or suppress. Thus, the establishment of infection is genetically determined by the availa...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164914/ https://www.ncbi.nlm.nih.gov/pubmed/30201857 http://dx.doi.org/10.3390/v10090484 |
_version_ | 1783359713347371008 |
---|---|
author | Garcia-Ruiz, Hernan |
author_facet | Garcia-Ruiz, Hernan |
author_sort | Garcia-Ruiz, Hernan |
collection | PubMed |
description | Plant viruses use cellular factors and resources to replicate and move. Plants respond to viral infection by several mechanisms, including innate immunity, autophagy, and gene silencing, that viruses must evade or suppress. Thus, the establishment of infection is genetically determined by the availability of host factors necessary for virus replication and movement and by the balance between plant defense and viral suppression of defense responses. Host factors may have antiviral or proviral activities. Proviral factors condition susceptibility to viruses by participating in processes essential to the virus. Here, we review current advances in the identification and characterization of host factors that condition susceptibility to plant viruses. Host factors with proviral activity have been identified for all parts of the virus infection cycle: viral RNA translation, viral replication complex formation, accumulation or activity of virus replication proteins, virus movement, and virion assembly. These factors could be targets of gene editing to engineer resistance to plant viruses. |
format | Online Article Text |
id | pubmed-6164914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61649142018-10-11 Susceptibility Genes to Plant Viruses Garcia-Ruiz, Hernan Viruses Review Plant viruses use cellular factors and resources to replicate and move. Plants respond to viral infection by several mechanisms, including innate immunity, autophagy, and gene silencing, that viruses must evade or suppress. Thus, the establishment of infection is genetically determined by the availability of host factors necessary for virus replication and movement and by the balance between plant defense and viral suppression of defense responses. Host factors may have antiviral or proviral activities. Proviral factors condition susceptibility to viruses by participating in processes essential to the virus. Here, we review current advances in the identification and characterization of host factors that condition susceptibility to plant viruses. Host factors with proviral activity have been identified for all parts of the virus infection cycle: viral RNA translation, viral replication complex formation, accumulation or activity of virus replication proteins, virus movement, and virion assembly. These factors could be targets of gene editing to engineer resistance to plant viruses. MDPI 2018-09-10 /pmc/articles/PMC6164914/ /pubmed/30201857 http://dx.doi.org/10.3390/v10090484 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Garcia-Ruiz, Hernan Susceptibility Genes to Plant Viruses |
title | Susceptibility Genes to Plant Viruses |
title_full | Susceptibility Genes to Plant Viruses |
title_fullStr | Susceptibility Genes to Plant Viruses |
title_full_unstemmed | Susceptibility Genes to Plant Viruses |
title_short | Susceptibility Genes to Plant Viruses |
title_sort | susceptibility genes to plant viruses |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164914/ https://www.ncbi.nlm.nih.gov/pubmed/30201857 http://dx.doi.org/10.3390/v10090484 |
work_keys_str_mv | AT garciaruizhernan susceptibilitygenestoplantviruses |