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The Dual Role of MicroRNAs in Colorectal Cancer Progression

Colorectal cancer (CRC) is responsible for one of the major cancer incidence and mortality worldwide. It is well known that MicroRNAs (miRNAs) play vital roles in maintaining the cell development and other physiological processes, as well as, the aberrant expression of numerous miRNAs involved in CR...

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Autores principales: Ding, Lei, Lan, Zhenwei, Xiong, Xianhui, Ao, Hongshun, Feng, Yingting, Gu, Huan, Yu, Min, Cui, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164944/
https://www.ncbi.nlm.nih.gov/pubmed/30227605
http://dx.doi.org/10.3390/ijms19092791
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author Ding, Lei
Lan, Zhenwei
Xiong, Xianhui
Ao, Hongshun
Feng, Yingting
Gu, Huan
Yu, Min
Cui, Qinghua
author_facet Ding, Lei
Lan, Zhenwei
Xiong, Xianhui
Ao, Hongshun
Feng, Yingting
Gu, Huan
Yu, Min
Cui, Qinghua
author_sort Ding, Lei
collection PubMed
description Colorectal cancer (CRC) is responsible for one of the major cancer incidence and mortality worldwide. It is well known that MicroRNAs (miRNAs) play vital roles in maintaining the cell development and other physiological processes, as well as, the aberrant expression of numerous miRNAs involved in CRC progression. MiRNAs are a class of small, endogenous, non-coding, single-stranded RNAs that bind to the 3’-untranslated region (3′-UTR) complementary sequences of their target mRNA, resulting in mRNA degradation or inhibition of its translation as a post-transcriptional regulators. Moreover, miRNAs also can target the long non-coding RNA (lncRNA) to regulate the expression of its target genes involved in proliferation and metastasis of CRC. The functions of these dysregulated miRNAs appear to be context specific, with evidence of having a dual role in both oncogenes and tumor suppression depending on the cellular environment in which they are expressed. Therefore, the unique expression profiles of miRNAs relate to the diagnosis, prognosis, and therapeutic outcome in CRC. In this review, we focused on several oncogenic and tumor-suppressive miRNAs specific to CRC, and assess their functions to uncover the molecular mechanisms of tumor initiation and progression in CRC. These data promised that miRNAs can be used as early detection biomarkers and potential therapeutic target in CRC patients.
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spelling pubmed-61649442018-10-10 The Dual Role of MicroRNAs in Colorectal Cancer Progression Ding, Lei Lan, Zhenwei Xiong, Xianhui Ao, Hongshun Feng, Yingting Gu, Huan Yu, Min Cui, Qinghua Int J Mol Sci Review Colorectal cancer (CRC) is responsible for one of the major cancer incidence and mortality worldwide. It is well known that MicroRNAs (miRNAs) play vital roles in maintaining the cell development and other physiological processes, as well as, the aberrant expression of numerous miRNAs involved in CRC progression. MiRNAs are a class of small, endogenous, non-coding, single-stranded RNAs that bind to the 3’-untranslated region (3′-UTR) complementary sequences of their target mRNA, resulting in mRNA degradation or inhibition of its translation as a post-transcriptional regulators. Moreover, miRNAs also can target the long non-coding RNA (lncRNA) to regulate the expression of its target genes involved in proliferation and metastasis of CRC. The functions of these dysregulated miRNAs appear to be context specific, with evidence of having a dual role in both oncogenes and tumor suppression depending on the cellular environment in which they are expressed. Therefore, the unique expression profiles of miRNAs relate to the diagnosis, prognosis, and therapeutic outcome in CRC. In this review, we focused on several oncogenic and tumor-suppressive miRNAs specific to CRC, and assess their functions to uncover the molecular mechanisms of tumor initiation and progression in CRC. These data promised that miRNAs can be used as early detection biomarkers and potential therapeutic target in CRC patients. MDPI 2018-09-17 /pmc/articles/PMC6164944/ /pubmed/30227605 http://dx.doi.org/10.3390/ijms19092791 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ding, Lei
Lan, Zhenwei
Xiong, Xianhui
Ao, Hongshun
Feng, Yingting
Gu, Huan
Yu, Min
Cui, Qinghua
The Dual Role of MicroRNAs in Colorectal Cancer Progression
title The Dual Role of MicroRNAs in Colorectal Cancer Progression
title_full The Dual Role of MicroRNAs in Colorectal Cancer Progression
title_fullStr The Dual Role of MicroRNAs in Colorectal Cancer Progression
title_full_unstemmed The Dual Role of MicroRNAs in Colorectal Cancer Progression
title_short The Dual Role of MicroRNAs in Colorectal Cancer Progression
title_sort dual role of micrornas in colorectal cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164944/
https://www.ncbi.nlm.nih.gov/pubmed/30227605
http://dx.doi.org/10.3390/ijms19092791
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