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Effects of Inflammation on Biomarkers of Vitamin A Status among a Cohort of Bolivian Infants

Globally, vitamin A deficiency (VAD) affects nearly 200 million children with negative health consequences. VAD can be measured by a retinol-binding protein (RBP) and serum retinol concentrations. Their concentrations are not always present in a 1:1 molar ratio and are affected by inflammation. This...

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Autores principales: Burke, Rachel M., Whitehead, Ralph D., Figueroa, Janet, Whelan, Denis, Aceituno, Anna M., Rebolledo, Paulina A., Revollo, Rita, Leon, Juan S., Suchdev, Parminder S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164950/
https://www.ncbi.nlm.nih.gov/pubmed/30189693
http://dx.doi.org/10.3390/nu10091240
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author Burke, Rachel M.
Whitehead, Ralph D.
Figueroa, Janet
Whelan, Denis
Aceituno, Anna M.
Rebolledo, Paulina A.
Revollo, Rita
Leon, Juan S.
Suchdev, Parminder S.
author_facet Burke, Rachel M.
Whitehead, Ralph D.
Figueroa, Janet
Whelan, Denis
Aceituno, Anna M.
Rebolledo, Paulina A.
Revollo, Rita
Leon, Juan S.
Suchdev, Parminder S.
author_sort Burke, Rachel M.
collection PubMed
description Globally, vitamin A deficiency (VAD) affects nearly 200 million children with negative health consequences. VAD can be measured by a retinol-binding protein (RBP) and serum retinol concentrations. Their concentrations are not always present in a 1:1 molar ratio and are affected by inflammation. This study sought to quantify VAD and its impact on infant mortality and infectious morbidity during the first 18 months of life in a cohort of mother-infant dyads in El Alto, Bolivia, while accounting for the previously mentioned measurement issues. Healthy mother-infant dyads (n = 461) were enrolled from two hospitals and followed for 12 to 18 months. Three serum samples were collected (at one to two, six to eight, and 12 to 18 months of infant age) and analyzed for RBP, and a random 10% subsample was analyzed for retinol. Linear regression of RBP on retinol was used to generate RBP cut-offs equivalent to retinol <0.7 µmol/L. All measures of RBP and retinol were adjusted for inflammation, which was measured by a C-reactive protein and alpha (1)-acid glycoprotein serum concentrations using linear regression. Infant mortality and morbidity rates were calculated and compared by early VAD status at two months of age. Retinol and RBP were weakly affected by inflammation. This association varied with infant age. Estimated VAD (RBP < 0.7 µmol/L) decreased from 71.0% to 14.8% to 7.7% at two, six to eight, and 12 to 18 months of age. VAD was almost nonexistent in mothers. Early VAD was not significantly associated with infant mortality or morbidity rates. This study confirmed a relationship between inflammation and vitamin A biomarkers for some subsets of the population and suggested that the vitamin A status in early infancy improves with age and may not have significantly affected morbidity in this population of healthy infants.
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spelling pubmed-61649502018-10-10 Effects of Inflammation on Biomarkers of Vitamin A Status among a Cohort of Bolivian Infants Burke, Rachel M. Whitehead, Ralph D. Figueroa, Janet Whelan, Denis Aceituno, Anna M. Rebolledo, Paulina A. Revollo, Rita Leon, Juan S. Suchdev, Parminder S. Nutrients Article Globally, vitamin A deficiency (VAD) affects nearly 200 million children with negative health consequences. VAD can be measured by a retinol-binding protein (RBP) and serum retinol concentrations. Their concentrations are not always present in a 1:1 molar ratio and are affected by inflammation. This study sought to quantify VAD and its impact on infant mortality and infectious morbidity during the first 18 months of life in a cohort of mother-infant dyads in El Alto, Bolivia, while accounting for the previously mentioned measurement issues. Healthy mother-infant dyads (n = 461) were enrolled from two hospitals and followed for 12 to 18 months. Three serum samples were collected (at one to two, six to eight, and 12 to 18 months of infant age) and analyzed for RBP, and a random 10% subsample was analyzed for retinol. Linear regression of RBP on retinol was used to generate RBP cut-offs equivalent to retinol <0.7 µmol/L. All measures of RBP and retinol were adjusted for inflammation, which was measured by a C-reactive protein and alpha (1)-acid glycoprotein serum concentrations using linear regression. Infant mortality and morbidity rates were calculated and compared by early VAD status at two months of age. Retinol and RBP were weakly affected by inflammation. This association varied with infant age. Estimated VAD (RBP < 0.7 µmol/L) decreased from 71.0% to 14.8% to 7.7% at two, six to eight, and 12 to 18 months of age. VAD was almost nonexistent in mothers. Early VAD was not significantly associated with infant mortality or morbidity rates. This study confirmed a relationship between inflammation and vitamin A biomarkers for some subsets of the population and suggested that the vitamin A status in early infancy improves with age and may not have significantly affected morbidity in this population of healthy infants. MDPI 2018-09-05 /pmc/articles/PMC6164950/ /pubmed/30189693 http://dx.doi.org/10.3390/nu10091240 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Burke, Rachel M.
Whitehead, Ralph D.
Figueroa, Janet
Whelan, Denis
Aceituno, Anna M.
Rebolledo, Paulina A.
Revollo, Rita
Leon, Juan S.
Suchdev, Parminder S.
Effects of Inflammation on Biomarkers of Vitamin A Status among a Cohort of Bolivian Infants
title Effects of Inflammation on Biomarkers of Vitamin A Status among a Cohort of Bolivian Infants
title_full Effects of Inflammation on Biomarkers of Vitamin A Status among a Cohort of Bolivian Infants
title_fullStr Effects of Inflammation on Biomarkers of Vitamin A Status among a Cohort of Bolivian Infants
title_full_unstemmed Effects of Inflammation on Biomarkers of Vitamin A Status among a Cohort of Bolivian Infants
title_short Effects of Inflammation on Biomarkers of Vitamin A Status among a Cohort of Bolivian Infants
title_sort effects of inflammation on biomarkers of vitamin a status among a cohort of bolivian infants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164950/
https://www.ncbi.nlm.nih.gov/pubmed/30189693
http://dx.doi.org/10.3390/nu10091240
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