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Testosterone Levels and Type 2 Diabetes—No Correlation with Age, Differential Predictive Value in Men and Women

Most studies reporting on the association of circulating testosterone levels with type 2 diabetes in men are of cross-sectional design. Reports on the relevance of altered testosterone levels in women are scarce. Here, we evaluate the role of low serum testosterone levels for incident diabetes in me...

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Autores principales: Karakas, Mahir, Schäfer, Sarina, Appelbaum, Sebastian, Ojeda, Francisco, Kuulasmaa, Kari, Brückmann, Burkhard, Berisha, Filip, Schulte-Steinberg, Benedikt, Jousilahti, Pekka, Blankenberg, Stefan, Palosaari, Tarja, Salomaa, Veikko, Zeller, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165105/
https://www.ncbi.nlm.nih.gov/pubmed/30127326
http://dx.doi.org/10.3390/biom8030076
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author Karakas, Mahir
Schäfer, Sarina
Appelbaum, Sebastian
Ojeda, Francisco
Kuulasmaa, Kari
Brückmann, Burkhard
Berisha, Filip
Schulte-Steinberg, Benedikt
Jousilahti, Pekka
Blankenberg, Stefan
Palosaari, Tarja
Salomaa, Veikko
Zeller, Tanja
author_facet Karakas, Mahir
Schäfer, Sarina
Appelbaum, Sebastian
Ojeda, Francisco
Kuulasmaa, Kari
Brückmann, Burkhard
Berisha, Filip
Schulte-Steinberg, Benedikt
Jousilahti, Pekka
Blankenberg, Stefan
Palosaari, Tarja
Salomaa, Veikko
Zeller, Tanja
author_sort Karakas, Mahir
collection PubMed
description Most studies reporting on the association of circulating testosterone levels with type 2 diabetes in men are of cross-sectional design. Reports on the relevance of altered testosterone levels in women are scarce. Here, we evaluate the role of low serum testosterone levels for incident diabetes in men and women in a population setting of 7706 subjects (3896 females). During a mean follow up time of 13.8 years, 7.8% developed type 2 diabetes. Significant correlations of testosterone with high density lipoprotein (HDL)-cholesterol (R = 0.21, p < 0.001), body-mass-index (R = −0.23, p < 0.001), and waist-to-hip-ratio (R = −0.21, p < 0.001) were found in men. No correlation was found with age in men; in women, the correlation was negligible (R = 0.04, p = 0.012). In men, low testosterone levels predicted high risk of type 2 diabetes, while in women this relationship was opposite. Men with low testosterone levels showed increased risk of future diabetes (hazard ratio (HR) 2.66, 95% confidence interval (CI) 1.91–3.72, p < 0.001 in basic model; HR 1.56 95%, CI 1.10–2.21, p = 0.003). In women, low testosterone levels indicated lower risk with (HR 0.53, 95% CI 0.37–0.77, p = 0.003), while the association lost significance in the fully adjusted model (HR 0.72, 95% CI 0.49–1.05, p = 0.09). Low levels of testosterone predicted future diabetes in men. A borderline opposite association was found in women.
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spelling pubmed-61651052018-10-10 Testosterone Levels and Type 2 Diabetes—No Correlation with Age, Differential Predictive Value in Men and Women Karakas, Mahir Schäfer, Sarina Appelbaum, Sebastian Ojeda, Francisco Kuulasmaa, Kari Brückmann, Burkhard Berisha, Filip Schulte-Steinberg, Benedikt Jousilahti, Pekka Blankenberg, Stefan Palosaari, Tarja Salomaa, Veikko Zeller, Tanja Biomolecules Article Most studies reporting on the association of circulating testosterone levels with type 2 diabetes in men are of cross-sectional design. Reports on the relevance of altered testosterone levels in women are scarce. Here, we evaluate the role of low serum testosterone levels for incident diabetes in men and women in a population setting of 7706 subjects (3896 females). During a mean follow up time of 13.8 years, 7.8% developed type 2 diabetes. Significant correlations of testosterone with high density lipoprotein (HDL)-cholesterol (R = 0.21, p < 0.001), body-mass-index (R = −0.23, p < 0.001), and waist-to-hip-ratio (R = −0.21, p < 0.001) were found in men. No correlation was found with age in men; in women, the correlation was negligible (R = 0.04, p = 0.012). In men, low testosterone levels predicted high risk of type 2 diabetes, while in women this relationship was opposite. Men with low testosterone levels showed increased risk of future diabetes (hazard ratio (HR) 2.66, 95% confidence interval (CI) 1.91–3.72, p < 0.001 in basic model; HR 1.56 95%, CI 1.10–2.21, p = 0.003). In women, low testosterone levels indicated lower risk with (HR 0.53, 95% CI 0.37–0.77, p = 0.003), while the association lost significance in the fully adjusted model (HR 0.72, 95% CI 0.49–1.05, p = 0.09). Low levels of testosterone predicted future diabetes in men. A borderline opposite association was found in women. MDPI 2018-08-20 /pmc/articles/PMC6165105/ /pubmed/30127326 http://dx.doi.org/10.3390/biom8030076 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Karakas, Mahir
Schäfer, Sarina
Appelbaum, Sebastian
Ojeda, Francisco
Kuulasmaa, Kari
Brückmann, Burkhard
Berisha, Filip
Schulte-Steinberg, Benedikt
Jousilahti, Pekka
Blankenberg, Stefan
Palosaari, Tarja
Salomaa, Veikko
Zeller, Tanja
Testosterone Levels and Type 2 Diabetes—No Correlation with Age, Differential Predictive Value in Men and Women
title Testosterone Levels and Type 2 Diabetes—No Correlation with Age, Differential Predictive Value in Men and Women
title_full Testosterone Levels and Type 2 Diabetes—No Correlation with Age, Differential Predictive Value in Men and Women
title_fullStr Testosterone Levels and Type 2 Diabetes—No Correlation with Age, Differential Predictive Value in Men and Women
title_full_unstemmed Testosterone Levels and Type 2 Diabetes—No Correlation with Age, Differential Predictive Value in Men and Women
title_short Testosterone Levels and Type 2 Diabetes—No Correlation with Age, Differential Predictive Value in Men and Women
title_sort testosterone levels and type 2 diabetes—no correlation with age, differential predictive value in men and women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165105/
https://www.ncbi.nlm.nih.gov/pubmed/30127326
http://dx.doi.org/10.3390/biom8030076
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