New Developments in the Synthesis of EMICORON

This paper reports on the modification of two synthetic steps in the usual protocol used for obtaining EMICORON. EMICORON is a benzo[ghi]perylen-diimide, which was synthesized for the first time in our laboratory in 2012, and has shown to have in vivo antitumor activities that interferes with the tu...

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Autores principales: Pitorri, Massimo, Franceschin, Marco, Serafini, Ilaria, Ciccòla, Alessandro, Frezza, Claudio, Bianco, Armandodoriano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165106/
https://www.ncbi.nlm.nih.gov/pubmed/30158479
http://dx.doi.org/10.3390/ht7030022
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author Pitorri, Massimo
Franceschin, Marco
Serafini, Ilaria
Ciccòla, Alessandro
Frezza, Claudio
Bianco, Armandodoriano
author_facet Pitorri, Massimo
Franceschin, Marco
Serafini, Ilaria
Ciccòla, Alessandro
Frezza, Claudio
Bianco, Armandodoriano
author_sort Pitorri, Massimo
collection PubMed
description This paper reports on the modification of two synthetic steps in the usual protocol used for obtaining EMICORON. EMICORON is a benzo[ghi]perylen-diimide, which was synthesized for the first time in our laboratory in 2012, and has shown to have in vivo antitumor activities that interferes with the tumor growth and development using a multi-target mechanism of action. The provided modifications, which involved the reaction times, the reaction conditions, and the work-up procedures, allowed the global yield of the process to be increased from 28% to about 40%. Thus, this new procedure may be more suitable for recovering higher amounts of EMICORON to be used in further preclinical studies.
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spelling pubmed-61651062018-10-11 New Developments in the Synthesis of EMICORON Pitorri, Massimo Franceschin, Marco Serafini, Ilaria Ciccòla, Alessandro Frezza, Claudio Bianco, Armandodoriano High Throughput Article This paper reports on the modification of two synthetic steps in the usual protocol used for obtaining EMICORON. EMICORON is a benzo[ghi]perylen-diimide, which was synthesized for the first time in our laboratory in 2012, and has shown to have in vivo antitumor activities that interferes with the tumor growth and development using a multi-target mechanism of action. The provided modifications, which involved the reaction times, the reaction conditions, and the work-up procedures, allowed the global yield of the process to be increased from 28% to about 40%. Thus, this new procedure may be more suitable for recovering higher amounts of EMICORON to be used in further preclinical studies. MDPI 2018-08-29 /pmc/articles/PMC6165106/ /pubmed/30158479 http://dx.doi.org/10.3390/ht7030022 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pitorri, Massimo
Franceschin, Marco
Serafini, Ilaria
Ciccòla, Alessandro
Frezza, Claudio
Bianco, Armandodoriano
New Developments in the Synthesis of EMICORON
title New Developments in the Synthesis of EMICORON
title_full New Developments in the Synthesis of EMICORON
title_fullStr New Developments in the Synthesis of EMICORON
title_full_unstemmed New Developments in the Synthesis of EMICORON
title_short New Developments in the Synthesis of EMICORON
title_sort new developments in the synthesis of emicoron
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165106/
https://www.ncbi.nlm.nih.gov/pubmed/30158479
http://dx.doi.org/10.3390/ht7030022
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