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Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications

Healthcare-associated infections and the rise of drug-resistant bacteria pose significant challenges to existing antibiotic therapies. Silver nanocomposites are a promising solution to the current crisis, however their therapeutic application requires improved understanding of underpinning structure...

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Autores principales: Isaacs, Mark A., Barbero, Brunella, Durndell, Lee J., Hilton, Anthony C., Olivi, Luca, Parlett, Christopher M. A., Wilson, Karen, Lee, Adam F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165165/
https://www.ncbi.nlm.nih.gov/pubmed/29970796
http://dx.doi.org/10.3390/antibiotics7030055
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author Isaacs, Mark A.
Barbero, Brunella
Durndell, Lee J.
Hilton, Anthony C.
Olivi, Luca
Parlett, Christopher M. A.
Wilson, Karen
Lee, Adam F.
author_facet Isaacs, Mark A.
Barbero, Brunella
Durndell, Lee J.
Hilton, Anthony C.
Olivi, Luca
Parlett, Christopher M. A.
Wilson, Karen
Lee, Adam F.
author_sort Isaacs, Mark A.
collection PubMed
description Healthcare-associated infections and the rise of drug-resistant bacteria pose significant challenges to existing antibiotic therapies. Silver nanocomposites are a promising solution to the current crisis, however their therapeutic application requires improved understanding of underpinning structure-function relationships. A family of chemically and structurally modified mesoporous SBA-15 silicas were synthesized as porous host matrices to tune the physicochemical properties of silver nanoparticles. Physicochemical characterization by transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), X-ray absorption near-edge spectroscopy (XANES) and porosimetry demonstrate that functionalization by a titania monolayer and the incorporation of macroporosity both increase silver nanoparticle dispersion throughout the silica matrix, thereby promoting Ag(2)CO(3) formation and the release of ionic silver in simulated tissue fluid. The Ag(2)CO(3) concentration within functionalized porous architectures is a strong predictor for antibacterial efficacy against a broad spectrum of pathogens, including C. difficile and methicillin-resistant Staphylococcus aureus (MRSA).
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spelling pubmed-61651652018-10-12 Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications Isaacs, Mark A. Barbero, Brunella Durndell, Lee J. Hilton, Anthony C. Olivi, Luca Parlett, Christopher M. A. Wilson, Karen Lee, Adam F. Antibiotics (Basel) Article Healthcare-associated infections and the rise of drug-resistant bacteria pose significant challenges to existing antibiotic therapies. Silver nanocomposites are a promising solution to the current crisis, however their therapeutic application requires improved understanding of underpinning structure-function relationships. A family of chemically and structurally modified mesoporous SBA-15 silicas were synthesized as porous host matrices to tune the physicochemical properties of silver nanoparticles. Physicochemical characterization by transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), X-ray absorption near-edge spectroscopy (XANES) and porosimetry demonstrate that functionalization by a titania monolayer and the incorporation of macroporosity both increase silver nanoparticle dispersion throughout the silica matrix, thereby promoting Ag(2)CO(3) formation and the release of ionic silver in simulated tissue fluid. The Ag(2)CO(3) concentration within functionalized porous architectures is a strong predictor for antibacterial efficacy against a broad spectrum of pathogens, including C. difficile and methicillin-resistant Staphylococcus aureus (MRSA). MDPI 2018-07-03 /pmc/articles/PMC6165165/ /pubmed/29970796 http://dx.doi.org/10.3390/antibiotics7030055 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Isaacs, Mark A.
Barbero, Brunella
Durndell, Lee J.
Hilton, Anthony C.
Olivi, Luca
Parlett, Christopher M. A.
Wilson, Karen
Lee, Adam F.
Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications
title Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications
title_full Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications
title_fullStr Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications
title_full_unstemmed Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications
title_short Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications
title_sort tunable silver-functionalized porous frameworks for antibacterial applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165165/
https://www.ncbi.nlm.nih.gov/pubmed/29970796
http://dx.doi.org/10.3390/antibiotics7030055
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