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Carnosine Supplementation Improves Serum Resistin Concentrations in Overweight or Obese Otherwise Healthy Adults: A Pilot Randomized Trial

Adipokines play an important role in the regulation of glucose metabolism. We have previously shown that carnosine supplementation in overweight or obese non-diabetic individuals improves glucose metabolism but does not change adiponectin concentrations. However, its effect on other adipokines has n...

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Autores principales: Baye, Estifanos, Ukropec, Jozef, de Courten, Maximilian P. J., Mousa, Aya, Kurdiova, Timea, Johnson, Josphin, Wilson, Kirsty, Plebanski, Magdalena, Aldini, Giancarlo, Ukropcova, Barbara, de Courten, Barbora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165206/
https://www.ncbi.nlm.nih.gov/pubmed/30205427
http://dx.doi.org/10.3390/nu10091258
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author Baye, Estifanos
Ukropec, Jozef
de Courten, Maximilian P. J.
Mousa, Aya
Kurdiova, Timea
Johnson, Josphin
Wilson, Kirsty
Plebanski, Magdalena
Aldini, Giancarlo
Ukropcova, Barbara
de Courten, Barbora
author_facet Baye, Estifanos
Ukropec, Jozef
de Courten, Maximilian P. J.
Mousa, Aya
Kurdiova, Timea
Johnson, Josphin
Wilson, Kirsty
Plebanski, Magdalena
Aldini, Giancarlo
Ukropcova, Barbara
de Courten, Barbora
author_sort Baye, Estifanos
collection PubMed
description Adipokines play an important role in the regulation of glucose metabolism. We have previously shown that carnosine supplementation in overweight or obese non-diabetic individuals improves glucose metabolism but does not change adiponectin concentrations. However, its effect on other adipokines has not been investigated. Herein we further determined the effect of carnosine supplementation on serum adipsin, resistin and leptin. Twenty-two overweight or obese otherwise healthy adults were randomly assigned to receive either 2 g of carnosine (n = 13) or identically looking placebo (n = 9) for 12 weeks. Serum adipsin, leptin and resistin were analyzed using a bead-based multiplex assay. Carnosine supplementation decreased serum resistin concentrations compared to placebo (mean change from baseline: −35 ± 83 carnosine vs. 35 ± 55 ng/mL placebo, p = 0.04). There was a trend for a reduction in serum leptin concentrations after carnosine supplementation (−76 ± 165 ng/mL carnosine vs. 20 ± 28 ng/mL placebo, p = 0.06). The changes in leptin and resistin concentrations were inversely related to the change in concentration for urinary carnosine (r = −0.72, p = 0.0002; r = −0.67, p = 0.0009, respectively), carnosine-propanal (r = −0.56, p = 0.005; r = −0.63, p = 0.001, respectively) and carnosine-propanol (r = −0.61, p = 0.002; r = −0.60, p = 0.002, respectively). There were no differences between groups in change in adipsin concentrations. Our findings show carnosine supplementation may normalize some, but not all, of the serum adipokine concentrations involved in glucose metabolism, in overweight and obese individuals. Further clinical trials with larger samples are needed to confirm these results.
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spelling pubmed-61652062018-10-10 Carnosine Supplementation Improves Serum Resistin Concentrations in Overweight or Obese Otherwise Healthy Adults: A Pilot Randomized Trial Baye, Estifanos Ukropec, Jozef de Courten, Maximilian P. J. Mousa, Aya Kurdiova, Timea Johnson, Josphin Wilson, Kirsty Plebanski, Magdalena Aldini, Giancarlo Ukropcova, Barbara de Courten, Barbora Nutrients Article Adipokines play an important role in the regulation of glucose metabolism. We have previously shown that carnosine supplementation in overweight or obese non-diabetic individuals improves glucose metabolism but does not change adiponectin concentrations. However, its effect on other adipokines has not been investigated. Herein we further determined the effect of carnosine supplementation on serum adipsin, resistin and leptin. Twenty-two overweight or obese otherwise healthy adults were randomly assigned to receive either 2 g of carnosine (n = 13) or identically looking placebo (n = 9) for 12 weeks. Serum adipsin, leptin and resistin were analyzed using a bead-based multiplex assay. Carnosine supplementation decreased serum resistin concentrations compared to placebo (mean change from baseline: −35 ± 83 carnosine vs. 35 ± 55 ng/mL placebo, p = 0.04). There was a trend for a reduction in serum leptin concentrations after carnosine supplementation (−76 ± 165 ng/mL carnosine vs. 20 ± 28 ng/mL placebo, p = 0.06). The changes in leptin and resistin concentrations were inversely related to the change in concentration for urinary carnosine (r = −0.72, p = 0.0002; r = −0.67, p = 0.0009, respectively), carnosine-propanal (r = −0.56, p = 0.005; r = −0.63, p = 0.001, respectively) and carnosine-propanol (r = −0.61, p = 0.002; r = −0.60, p = 0.002, respectively). There were no differences between groups in change in adipsin concentrations. Our findings show carnosine supplementation may normalize some, but not all, of the serum adipokine concentrations involved in glucose metabolism, in overweight and obese individuals. Further clinical trials with larger samples are needed to confirm these results. MDPI 2018-09-07 /pmc/articles/PMC6165206/ /pubmed/30205427 http://dx.doi.org/10.3390/nu10091258 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baye, Estifanos
Ukropec, Jozef
de Courten, Maximilian P. J.
Mousa, Aya
Kurdiova, Timea
Johnson, Josphin
Wilson, Kirsty
Plebanski, Magdalena
Aldini, Giancarlo
Ukropcova, Barbara
de Courten, Barbora
Carnosine Supplementation Improves Serum Resistin Concentrations in Overweight or Obese Otherwise Healthy Adults: A Pilot Randomized Trial
title Carnosine Supplementation Improves Serum Resistin Concentrations in Overweight or Obese Otherwise Healthy Adults: A Pilot Randomized Trial
title_full Carnosine Supplementation Improves Serum Resistin Concentrations in Overweight or Obese Otherwise Healthy Adults: A Pilot Randomized Trial
title_fullStr Carnosine Supplementation Improves Serum Resistin Concentrations in Overweight or Obese Otherwise Healthy Adults: A Pilot Randomized Trial
title_full_unstemmed Carnosine Supplementation Improves Serum Resistin Concentrations in Overweight or Obese Otherwise Healthy Adults: A Pilot Randomized Trial
title_short Carnosine Supplementation Improves Serum Resistin Concentrations in Overweight or Obese Otherwise Healthy Adults: A Pilot Randomized Trial
title_sort carnosine supplementation improves serum resistin concentrations in overweight or obese otherwise healthy adults: a pilot randomized trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165206/
https://www.ncbi.nlm.nih.gov/pubmed/30205427
http://dx.doi.org/10.3390/nu10091258
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