The Expanding Role of Radiosurgery for Brain Metastases

Stereotactic radiosurgery (SRS) has become increasingly important in the management of brain metastases due to improving systemic disease control and rising incidence. Initial trials demonstrated SRS with whole-brain radiotherapy (WBRT) improved local control rates compared with WBRT alone. Concerns...

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Autores principales: O’Beirn, Mark, Benghiat, Helen, Meade, Sara, Heyes, Geoff, Sawlani, Vijay, Kong, Anthony, Hartley, Andrew, Sanghera, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165316/
https://www.ncbi.nlm.nih.gov/pubmed/30110927
http://dx.doi.org/10.3390/medicines5030090
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author O’Beirn, Mark
Benghiat, Helen
Meade, Sara
Heyes, Geoff
Sawlani, Vijay
Kong, Anthony
Hartley, Andrew
Sanghera, Paul
author_facet O’Beirn, Mark
Benghiat, Helen
Meade, Sara
Heyes, Geoff
Sawlani, Vijay
Kong, Anthony
Hartley, Andrew
Sanghera, Paul
author_sort O’Beirn, Mark
collection PubMed
description Stereotactic radiosurgery (SRS) has become increasingly important in the management of brain metastases due to improving systemic disease control and rising incidence. Initial trials demonstrated SRS with whole-brain radiotherapy (WBRT) improved local control rates compared with WBRT alone. Concerns with WBRT associated neurocognitive toxicity have contributed to a greater use of SRS alone, including for patients with multiple metastases and following surgical resection. Molecular information, targeted agents, and immunotherapy have also altered the landscape for the management of brain metastases. This review summarises current and emerging data on the role of SRS in the management of brain metastases.
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spelling pubmed-61653162018-10-10 The Expanding Role of Radiosurgery for Brain Metastases O’Beirn, Mark Benghiat, Helen Meade, Sara Heyes, Geoff Sawlani, Vijay Kong, Anthony Hartley, Andrew Sanghera, Paul Medicines (Basel) Review Stereotactic radiosurgery (SRS) has become increasingly important in the management of brain metastases due to improving systemic disease control and rising incidence. Initial trials demonstrated SRS with whole-brain radiotherapy (WBRT) improved local control rates compared with WBRT alone. Concerns with WBRT associated neurocognitive toxicity have contributed to a greater use of SRS alone, including for patients with multiple metastases and following surgical resection. Molecular information, targeted agents, and immunotherapy have also altered the landscape for the management of brain metastases. This review summarises current and emerging data on the role of SRS in the management of brain metastases. MDPI 2018-08-14 /pmc/articles/PMC6165316/ /pubmed/30110927 http://dx.doi.org/10.3390/medicines5030090 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
O’Beirn, Mark
Benghiat, Helen
Meade, Sara
Heyes, Geoff
Sawlani, Vijay
Kong, Anthony
Hartley, Andrew
Sanghera, Paul
The Expanding Role of Radiosurgery for Brain Metastases
title The Expanding Role of Radiosurgery for Brain Metastases
title_full The Expanding Role of Radiosurgery for Brain Metastases
title_fullStr The Expanding Role of Radiosurgery for Brain Metastases
title_full_unstemmed The Expanding Role of Radiosurgery for Brain Metastases
title_short The Expanding Role of Radiosurgery for Brain Metastases
title_sort expanding role of radiosurgery for brain metastases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165316/
https://www.ncbi.nlm.nih.gov/pubmed/30110927
http://dx.doi.org/10.3390/medicines5030090
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