Cargando…

Andrographolide Protects PC12 Cells Against β-Amyloid-Induced Autophagy-Associated Cell Death Through Activation of the Nrf2-Mediated p62 Signaling Pathway

Recent studies mentioned that Andrographolide (Andro), the main bioactive component of traditional Chinese medicine Andrographis paniculata, may be a potential natural product for treating Alzheimer's disease, but the underlining mechanism remains to be discovered. In this study, we investigate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gu, Lili, Yu, Qingqing, Li, Qin, Zhang, Lingxi, Lu, Hong, Zhang, Xinyue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165383/ https://www.ncbi.nlm.nih.gov/pubmed/30235892 http://dx.doi.org/10.3390/ijms19092844

Ejemplares similares

Andrographolide emeliorates maltol aluminium-induced neurotoxicity via regulating p62-mediated Keap1-Nrf2 pathways in PC12 cells
por: Lu, Jiaqi, et al.
Publicado: (2021)

Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta(25–35) via the Autophagy Pathway
por: Xu, Pengjuan, et al.
Publicado: (2015)

Protective Effects of Walnut Extract Against Amyloid Beta Peptide-Induced Cell Death and Oxidative Stress in PC12 Cells
por: Muthaiyah, Balu, et al.
Publicado: (2011)

Germacrone protects against oxygen-glucose deprivation/reperfusion injury by inhibiting autophagy processes in PC12 cells
por: Zhang, Jianxing, et al.
Publicado: (2020)

Taxifolin synergizes Andrographolide-induced cell death by attenuation of autophagy and augmentation of caspase dependent and independent cell death in HeLa cells
por: Alzaharna, Mazen, et al.
Publicado: (2017)

Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis
por: Hsu, Wei-Lun, et al.
Publicado: (2022)

Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells
por: Yen, Jui-Hung, et al.
Publicado: (2017)

β-Asarone Ameliorates β-Amyloid–Induced Neurotoxicity in PC12 Cells by Activating P13K/Akt/Nrf2 Signaling Pathway
por: Meng, Miaomiao, et al.
Publicado: (2021)

Mitogen-activated protein kinase phosphatase 1 protects PC12 cells from amyloid beta-induced neurotoxicity
por: Gu, Yue, et al.
Publicado: (2018)

Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop
por: Wang, Yang, et al.
Publicado: (2017)

Sulforaphane prevents PC12 cells from oxidative damage via the Nrf2 pathway
por: Bao, Bing, et al.
Publicado: (2019)

Andrographolide alleviates paraquat-induced acute lung injury by activating the Nrf2/HO-1 pathway
por: Zhang, Degang, et al.
Publicado: (2023)

Experimental study on the neurotoxic effect of β-amyloid on the cytoskeleton of PC12 cells
por: Wang, Lai, et al.
Publicado: (2018)

Vincamine Alleviates Amyloid-β 25–35 Peptides-induced Cytotoxicity in PC12 Cells
por: Han, Jianfeng, et al.
Publicado: (2017)

Ferulago angulata Methanolic Extract Protects PC12 Cells Against Beta-amyloid-induced Toxicity
por: Hashemi, Leila, et al.
Publicado: (2023)

Schisandrin B protects PC12 cells by decreasing the expression of amyloid precursor protein and vacuolar protein sorting 35★
por: Yan, Mingmin, et al.
Publicado: (2012)

Administration of Ketamine Causes Autophagy and Apoptosis in the Rat Fetal Hippocampus and in PC12 Cells
por: Li, Xinran, et al.
Publicado: (2018)

Zika Virus Envelope Protein induces G2/M Cell Cycle Arrest and Apoptosis via an Intrinsic Cell Death Signaling Pathway in Neuroendocrine PC12 Cells
por: Liu, Jun, et al.
Publicado: (2018)

Regucalcin confers resistance to amyloid‐β toxicity in neuronally differentiated PC12 cells
por: Murata, Tomiyasu, et al.
Publicado: (2018)

Andrographolide protects mouse astrocytes against hypoxia injury by promoting autophagy and S100B expression
por: Du, Juan, et al.
Publicado: (2018)

Inhibition by Anandamide of 6-Hydroxydopamine-Induced Cell Death in PC12 Cells
por: Mnich, Katarzyna, et al.
Publicado: (2010)

Stabilization of Nrf2 Protein by D3T Provides Protection against Ethanol-Induced Apoptosis in PC12 Cells
por: Dong, Jian, et al.
Publicado: (2011)

Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells
por: Wu, Pei-Shan, et al.
Publicado: (2015)

Andrographolide
por: Yan, Yu, et al.
Publicado: (2018)

Shikonin Protects PC12 Cells Against β-amyloid Peptide-Induced Cell Injury Through Antioxidant and Antiapoptotic Activities
por: Tong, Yuna, et al.
Publicado: (2018)

Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration
por: Tang, Zehan, et al.
Publicado: (2019)

Analogs of imine resveratrol alleviate oxidative stress‐induced neurotoxicity in PC12 cells via activation of Nrf2
por: Zhang, Yin, et al.
Publicado: (2021)

Andrographolide Analogue Induces Apoptosis and Autophagy Mediated Cell Death in U937 Cells by Inhibition of PI3K/Akt/mTOR Pathway
por: Kumar, Deepak, et al.
Publicado: (2015)

The Aqueous Extract of Rhizome of Gastrodia elata Protected Drosophila and PC12 Cells against Beta-Amyloid-Induced Neurotoxicity
por: Ng, Chun-Fai, et al.
Publicado: (2013)

Protective effects of components of the Chinese herb grassleaf sweetflag rhizome on PC12 cells incubated with amyloid-beta42
por: Liang, Zi-hao, et al.
Publicado: (2015)

Protective Effects of Selol Against Sodium Nitroprusside-Induced Cell Death and Oxidative Stress in PC12 Cells
por: Dominiak, Agnieszka, et al.
Publicado: (2016)

Protective effects of nimodipine and lithium against aluminum-induced cell death and oxidative stress in PC12 cells
por: Saberzadeh, Jamileh, et al.
Publicado: (2016)

Marliolide Derivative Induces Melanosome Degradation via Nrf2/p62-Mediated Autophagy
por: Yun, Cheong-Yong, et al.
Publicado: (2021)

Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment
por: Zhang, Zaijun, et al.
Publicado: (2009)

Icariside II, a novel phosphodiesterase 5 inhibitor, protects against H(2)O(2)‐induced PC12 cells death by inhibiting mitochondria‐mediated autophagy
por: Gao, Jianmei, et al.
Publicado: (2016)

Chlorogenic acid protects PC12 cells against corticosterone-induced neurotoxicity related to inhibition of autophagy and apoptosis
por: Shi, Xiaowen, et al.
Publicado: (2019)

Neuroprotective effects of hydrogen sulfide on sodium azide-induced autophagic cell death in PC12 cells
por: Shan, Haiyan, et al.
Publicado: (2017)

Regulation of the NRF2 transcription factor by andrographolide and organic extracts from plant endophytes
por: Wong, Daphne Pei Wen, et al.
Publicado: (2018)

Role of Notch-1 signaling pathway in PC12 cell apoptosis induced by amyloid beta-peptide (25–35)
por: Liang, Huimin, et al.
Publicado: (2014)

Oligomeric Forms of Insulin Amyloid Aggregation Disrupt Outgrowth and Complexity of Neuron-Like PC12 Cells
por: Kachooei, Ehsan, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_9ivi2lrcu54l8rv83d74dngd75