Cargando…

Poor Vitamin Status is Associated with Skeletal Muscle Loss and Mucositis in Head and Neck Cancer Patients

Mucositis and muscle wasting are two common toxicity effects of cancer treatment in head and neck cancer (HNC). There is limited data evaluating cancer treatment toxicities in relation to vitamin status. This study aimed to assess changes in vitamin status during HNC treatment in relation to body co...

Descripción completa

Detalles Bibliográficos
Autores principales: Nejatinamini, Sara, Debenham, Brock J., Clugston, Robin D., Mawani, Asifa, Parliament, Matthew, Wismer, Wendy V., Mazurak, Vera C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165496/
https://www.ncbi.nlm.nih.gov/pubmed/30189611
http://dx.doi.org/10.3390/nu10091236
_version_ 1783359851094605824
author Nejatinamini, Sara
Debenham, Brock J.
Clugston, Robin D.
Mawani, Asifa
Parliament, Matthew
Wismer, Wendy V.
Mazurak, Vera C.
author_facet Nejatinamini, Sara
Debenham, Brock J.
Clugston, Robin D.
Mawani, Asifa
Parliament, Matthew
Wismer, Wendy V.
Mazurak, Vera C.
author_sort Nejatinamini, Sara
collection PubMed
description Mucositis and muscle wasting are two common toxicity effects of cancer treatment in head and neck cancer (HNC). There is limited data evaluating cancer treatment toxicities in relation to vitamin status. This study aimed to assess changes in vitamin status during HNC treatment in relation to body composition, inflammation and mucositis. In this prospective cohort study, dietary intakes (3-day food record), plasma levels of vitamins and C-reactive protein (CRP) were assessed at baseline (at diagnosis) and post-treatment (after 6–8 weeks of radiation therapy with or without chemotherapy). Computed tomography images were used to quantify body composition. Mucositis information was collected from health records of patients. Twenty-eight HNC patients (age 60 ± 10 years) completed both study time points. Patients who developed mucositis had significantly lower dietary intake of vitamins and plasma 25-hydroxy vitamin D (25-OHD) and all-trans retinol levels (p < 0.02). Patients lost a considerable amount of muscle mass (3.4 kg) and fat mass (3.6 kg) over the course of treatment. There was a trend toward greater muscle loss in patients with 25-OHD < 50 nmol/L compared to patients with 25-OHD ≥ 50 nmol/L (p = 0.07). A significant negative correlation was found between plasma all-trans retinol and CRP level at the end of treatment (p = 0.03). Poor vitamin status could be a contributing factor in developing treatment-induced toxicities.
format Online
Article
Text
id pubmed-6165496
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-61654962018-10-10 Poor Vitamin Status is Associated with Skeletal Muscle Loss and Mucositis in Head and Neck Cancer Patients Nejatinamini, Sara Debenham, Brock J. Clugston, Robin D. Mawani, Asifa Parliament, Matthew Wismer, Wendy V. Mazurak, Vera C. Nutrients Article Mucositis and muscle wasting are two common toxicity effects of cancer treatment in head and neck cancer (HNC). There is limited data evaluating cancer treatment toxicities in relation to vitamin status. This study aimed to assess changes in vitamin status during HNC treatment in relation to body composition, inflammation and mucositis. In this prospective cohort study, dietary intakes (3-day food record), plasma levels of vitamins and C-reactive protein (CRP) were assessed at baseline (at diagnosis) and post-treatment (after 6–8 weeks of radiation therapy with or without chemotherapy). Computed tomography images were used to quantify body composition. Mucositis information was collected from health records of patients. Twenty-eight HNC patients (age 60 ± 10 years) completed both study time points. Patients who developed mucositis had significantly lower dietary intake of vitamins and plasma 25-hydroxy vitamin D (25-OHD) and all-trans retinol levels (p < 0.02). Patients lost a considerable amount of muscle mass (3.4 kg) and fat mass (3.6 kg) over the course of treatment. There was a trend toward greater muscle loss in patients with 25-OHD < 50 nmol/L compared to patients with 25-OHD ≥ 50 nmol/L (p = 0.07). A significant negative correlation was found between plasma all-trans retinol and CRP level at the end of treatment (p = 0.03). Poor vitamin status could be a contributing factor in developing treatment-induced toxicities. MDPI 2018-09-05 /pmc/articles/PMC6165496/ /pubmed/30189611 http://dx.doi.org/10.3390/nu10091236 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nejatinamini, Sara
Debenham, Brock J.
Clugston, Robin D.
Mawani, Asifa
Parliament, Matthew
Wismer, Wendy V.
Mazurak, Vera C.
Poor Vitamin Status is Associated with Skeletal Muscle Loss and Mucositis in Head and Neck Cancer Patients
title Poor Vitamin Status is Associated with Skeletal Muscle Loss and Mucositis in Head and Neck Cancer Patients
title_full Poor Vitamin Status is Associated with Skeletal Muscle Loss and Mucositis in Head and Neck Cancer Patients
title_fullStr Poor Vitamin Status is Associated with Skeletal Muscle Loss and Mucositis in Head and Neck Cancer Patients
title_full_unstemmed Poor Vitamin Status is Associated with Skeletal Muscle Loss and Mucositis in Head and Neck Cancer Patients
title_short Poor Vitamin Status is Associated with Skeletal Muscle Loss and Mucositis in Head and Neck Cancer Patients
title_sort poor vitamin status is associated with skeletal muscle loss and mucositis in head and neck cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165496/
https://www.ncbi.nlm.nih.gov/pubmed/30189611
http://dx.doi.org/10.3390/nu10091236
work_keys_str_mv AT nejatinaminisara poorvitaminstatusisassociatedwithskeletalmusclelossandmucositisinheadandneckcancerpatients
AT debenhambrockj poorvitaminstatusisassociatedwithskeletalmusclelossandmucositisinheadandneckcancerpatients
AT clugstonrobind poorvitaminstatusisassociatedwithskeletalmusclelossandmucositisinheadandneckcancerpatients
AT mawaniasifa poorvitaminstatusisassociatedwithskeletalmusclelossandmucositisinheadandneckcancerpatients
AT parliamentmatthew poorvitaminstatusisassociatedwithskeletalmusclelossandmucositisinheadandneckcancerpatients
AT wismerwendyv poorvitaminstatusisassociatedwithskeletalmusclelossandmucositisinheadandneckcancerpatients
AT mazurakverac poorvitaminstatusisassociatedwithskeletalmusclelossandmucositisinheadandneckcancerpatients