Severe tubulointerstitial nephritis: tracking tuberculosis even in the absence of renal granuloma

Extra-pulmonary tuberculosis is frequently located in the kidneys and, in such cases, could be associated with a granulomatous interstitial nephritis. Granulomas are not always detected, especially in human immunodeficiency virus (HIV)-positive patients. We report here a case of tubulointerstitial n...

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Autores principales: Delafosse, Marion, Teuma, Cécile, Miailhes, Patrick, Nouvier, Mathilde, Rabeyrin, Maud, Fouque, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Tubulointerstitial Nephritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165755/
https://www.ncbi.nlm.nih.gov/pubmed/30288262
http://dx.doi.org/10.1093/ckj/sfx157
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author Delafosse, Marion
Teuma, Cécile
Miailhes, Patrick
Nouvier, Mathilde
Rabeyrin, Maud
Fouque, Denis
author_facet Delafosse, Marion
Teuma, Cécile
Miailhes, Patrick
Nouvier, Mathilde
Rabeyrin, Maud
Fouque, Denis
author_sort Delafosse, Marion
collection PubMed
description Extra-pulmonary tuberculosis is frequently located in the kidneys and, in such cases, could be associated with a granulomatous interstitial nephritis. Granulomas are not always detected, especially in human immunodeficiency virus (HIV)-positive patients. We report here a case of tubulointerstitial nephritis without granulomas in an HIV-negative patient. Since all laboratory tests failed to isolate Mycobacterium tuberculosis in the kidney, a targeted biopsy guided by positron emission tomography–computed tomography was performed on a mediastinal node, revealing a positive culture. After 6 months of treatment, no recovery of the renal injury has been observed.
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spelling pubmed-61657552018-10-04 Severe tubulointerstitial nephritis: tracking tuberculosis even in the absence of renal granuloma Delafosse, Marion Teuma, Cécile Miailhes, Patrick Nouvier, Mathilde Rabeyrin, Maud Fouque, Denis Clin Kidney J Tubulointerstitial Nephritis Extra-pulmonary tuberculosis is frequently located in the kidneys and, in such cases, could be associated with a granulomatous interstitial nephritis. Granulomas are not always detected, especially in human immunodeficiency virus (HIV)-positive patients. We report here a case of tubulointerstitial nephritis without granulomas in an HIV-negative patient. Since all laboratory tests failed to isolate Mycobacterium tuberculosis in the kidney, a targeted biopsy guided by positron emission tomography–computed tomography was performed on a mediastinal node, revealing a positive culture. After 6 months of treatment, no recovery of the renal injury has been observed. Oxford University Press 2018-10 2018-01-23 /pmc/articles/PMC6165755/ /pubmed/30288262 http://dx.doi.org/10.1093/ckj/sfx157 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Tubulointerstitial Nephritis
Delafosse, Marion
Teuma, Cécile
Miailhes, Patrick
Nouvier, Mathilde
Rabeyrin, Maud
Fouque, Denis
Severe tubulointerstitial nephritis: tracking tuberculosis even in the absence of renal granuloma
title Severe tubulointerstitial nephritis: tracking tuberculosis even in the absence of renal granuloma
title_full Severe tubulointerstitial nephritis: tracking tuberculosis even in the absence of renal granuloma
title_fullStr Severe tubulointerstitial nephritis: tracking tuberculosis even in the absence of renal granuloma
title_full_unstemmed Severe tubulointerstitial nephritis: tracking tuberculosis even in the absence of renal granuloma
title_short Severe tubulointerstitial nephritis: tracking tuberculosis even in the absence of renal granuloma
title_sort severe tubulointerstitial nephritis: tracking tuberculosis even in the absence of renal granuloma
topic Tubulointerstitial Nephritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165755/
https://www.ncbi.nlm.nih.gov/pubmed/30288262
http://dx.doi.org/10.1093/ckj/sfx157
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