Immunomodulatory drugs downregulate IKZF1 leading to expansion of hematopoietic progenitors with concomitant block of megakaryocytic maturation

The immunomodulatory drugs, lenalidomide and pomalidomide yield high response rates in multiple myeloma patients, but are associated with a high rate of thrombocytopenia and increased risk of secondary hematologic malignancies. Here, we demonstrate that the immunomodulatory drugs induce self-renewal...

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Detalles Bibliográficos
Autores principales: Liu, Ailing, Li, Shirong, Donnenberg, Vera, Fu, Jing, Gollin, Susanne M., Ma, Huihui, Lu, Caisheng, Stolz, Donna B., Mapara, Markus Y., Monaghan, Sara A., Lentzsch, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2018
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165797/
https://www.ncbi.nlm.nih.gov/pubmed/29954930
http://dx.doi.org/10.3324/haematol.2018.188227

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