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SIRT1 in Secretory Organ Cancer
Mammalian silent information regulator 1 (SIRT1) is reported to play a role in cancers of the secretory organs, including thyroid, pancreatic endocrine, and ovarian tumors [1, 2, 3, 4]. A recent meta-analysis conducted on 37 selected studies of human cancers analyzed the correlations of overall surv...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165890/ https://www.ncbi.nlm.nih.gov/pubmed/30319549 http://dx.doi.org/10.3389/fendo.2018.00569 |
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author | Frazzi, Raffaele |
author_facet | Frazzi, Raffaele |
author_sort | Frazzi, Raffaele |
collection | PubMed |
description | Mammalian silent information regulator 1 (SIRT1) is reported to play a role in cancers of the secretory organs, including thyroid, pancreatic endocrine, and ovarian tumors [1, 2, 3, 4]. A recent meta-analysis conducted on 37 selected studies of human cancers analyzed the correlations of overall survival (OS), disease-free survival (DFS) and relapse-free survival (RFS) with SIRT1 expression [5]. This study reported that SIRT1 overexpression was associated with a worse OS in liver and lung cancers, while it was not correlated with OS in breast cancer, colorectal cancer, or gastric carcinoma. Collectively, the meta-analysis revealed that an unfavorable OS was associated with SIRT1 expression for solid malignancies. Given the growing importance of this class of lysine/histone deacetylases in human endocrine malignancies, a rational and focused literature assessment is desirable in light of future clinical translations. |
format | Online Article Text |
id | pubmed-6165890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61658902018-10-12 SIRT1 in Secretory Organ Cancer Frazzi, Raffaele Front Endocrinol (Lausanne) Endocrinology Mammalian silent information regulator 1 (SIRT1) is reported to play a role in cancers of the secretory organs, including thyroid, pancreatic endocrine, and ovarian tumors [1, 2, 3, 4]. A recent meta-analysis conducted on 37 selected studies of human cancers analyzed the correlations of overall survival (OS), disease-free survival (DFS) and relapse-free survival (RFS) with SIRT1 expression [5]. This study reported that SIRT1 overexpression was associated with a worse OS in liver and lung cancers, while it was not correlated with OS in breast cancer, colorectal cancer, or gastric carcinoma. Collectively, the meta-analysis revealed that an unfavorable OS was associated with SIRT1 expression for solid malignancies. Given the growing importance of this class of lysine/histone deacetylases in human endocrine malignancies, a rational and focused literature assessment is desirable in light of future clinical translations. Frontiers Media S.A. 2018-09-24 /pmc/articles/PMC6165890/ /pubmed/30319549 http://dx.doi.org/10.3389/fendo.2018.00569 Text en Copyright © 2018 Frazzi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Frazzi, Raffaele SIRT1 in Secretory Organ Cancer |
title | SIRT1 in Secretory Organ Cancer |
title_full | SIRT1 in Secretory Organ Cancer |
title_fullStr | SIRT1 in Secretory Organ Cancer |
title_full_unstemmed | SIRT1 in Secretory Organ Cancer |
title_short | SIRT1 in Secretory Organ Cancer |
title_sort | sirt1 in secretory organ cancer |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165890/ https://www.ncbi.nlm.nih.gov/pubmed/30319549 http://dx.doi.org/10.3389/fendo.2018.00569 |
work_keys_str_mv | AT frazziraffaele sirt1insecretoryorgancancer |