Cargando…

Cu(II)(atsm) Attenuates Neuroinflammation

Background: Neuroinflammation and biometal dyshomeostasis are key pathological features of several neurodegenerative diseases, including Alzheimer’s disease (AD). Inflammation and biometals are linked at the molecular level through regulation of metal buffering proteins such as the metallothioneins....

Descripción completa

Detalles Bibliográficos
Autores principales:	Choo, Xin Yi, Liddell, Jeffrey R., Huuskonen, Mikko T., Grubman, Alexandra, Moujalled, Diane, Roberts, Jessica, Kysenius, Kai, Patten, Lauren, Quek, Hazel, Oikari, Lotta E., Duncan, Clare, James, Simon A., McInnes, Lachlan E., Hayne, David J., Donnelly, Paul S., Pollari, Eveliina, Vähätalo, Suvi, Lejavová, Katarína, Kettunen, Mikko I., Malm, Tarja, Koistinaho, Jari, White, Anthony R., Kanninen, Katja M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165894/ https://www.ncbi.nlm.nih.gov/pubmed/30319344 http://dx.doi.org/10.3389/fnins.2018.00668

Ejemplares similares

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy
por: Huuskonen, Mikko T., et al.
Publicado: (2016)

Lack of collagen XV is protective after ischemic stroke in mice
por: Dhungana, Hiramani, et al.
Publicado: (2017)

Copper-ATSM as a Treatment for ALS: Support from Mutant SOD1 Models and Beyond
por: Nikseresht, Sara, et al.
Publicado: (2020)

Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation
por: Dhungana, Hiramani, et al.
Publicado: (2017)

Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications
por: Malm, Tarja, et al.
Publicado: (2011)

Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis
por: Pollari, Eveliina, et al.
Publicado: (2011)

Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder
por: Savchenko, Ekaterina, et al.
Publicado: (2017)

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis
por: Korhonen, Paula, et al.
Publicado: (2019)

Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway
por: Kanninen, Katja, et al.
Publicado: (2011)

Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
por: Kolosowska, Natalia, et al.
Publicado: (2020)

Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice
por: Puris, Elena, et al.
Publicado: (2021)

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo
por: Keuters, Meike Hedwig, et al.
Publicado: (2021)

Production of monocytic cells from bone marrow stem cells: therapeutic usage in Alzheimer’s disease
por: Magga, Johanna, et al.
Publicado: (2012)

Phosphorylation of hnRNP K controls cytosolic accumulation of TDP-43
por: White, Anthony, et al.
Publicado: (2013)

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease
por: Gynther, Mikko, et al.
Publicado: (2022)

Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's disease
por: Magga, Johanna, et al.
Publicado: (2010)

Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation
por: Byts, Nadiya, et al.
Publicado: (2022)

Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer’s Disease
por: Belaya, Irina, et al.
Publicado: (2021)

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex
por: Choo, Xin Yi, et al.
Publicado: (2022)

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration
por: Abdalkader, Moataz, et al.
Publicado: (2018)

Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes
por: Liddell, Jeffrey R., et al.
Publicado: (2016)

The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis
por: Pollari, Eveliina, et al.
Publicado: (2014)

Glycogen Synthase Kinase-3β: A Mediator of Inflammation in Alzheimer's Disease?
por: Koistinaho, Jari, et al.
Publicado: (2011)

Animal Models of Alzheimer’s Disease: Utilization of Transgenic Alzheimer’s Disease Models in Studies of Amyloid Beta Clearance
por: Malm, Tarja, et al.
Publicado: (2012)

ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
por: Lemarchant, Sighild, et al.
Publicado: (2016)

Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
por: Lemarchant, Sighild, et al.
Publicado: (2016)

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death
por: Martiskainen, Henna, et al.
Publicado: (2017)

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress
por: Moujalled, Diane, et al.
Publicado: (2013)

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder
por: Grubman, Alexandra, et al.
Publicado: (2014)

(64)Cu-ATSM and (18)FDG PET uptake and (64)Cu-ATSM autoradiography in spontaneous canine tumors: comparison with pimonidazole hypoxia immunohistochemistry
por: Hansen, Anders E, et al.
Publicado: (2012)

CuATSM efficacy is independently replicated in a SOD1 mouse model of ALS while unmetallated ATSM therapy fails to reveal benefits
por: Vieira, Fernando G., et al.
Publicado: (2017)

Gender-Specific Mechanism of Synaptic Impairment and Its Prevention by GCSF in a Mouse Model of ALS
por: Naumenko, Nikolay, et al.
Publicado: (2011)

Gene dysregulation is restored in the Parkinson’s disease MPTP neurotoxic mice model upon treatment of the therapeutic drug Cu(II)(atsm)
por: Cheng, Lesley, et al.
Publicado: (2016)

Cellular Uptake of the ATSM−Cu(II) Complex under Hypoxic Conditions
por: Walke, Gulshan R., et al.
Publicado: (2021)

Molecular mechanisms of cell death in neurological diseases
por: Moujalled, Diane, et al.
Publicado: (2021)

Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy
por: Leinonen, Henri, et al.
Publicado: (2017)

Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer’s disease
por: Puli, Lakshman, et al.
Publicado: (2012)

Does the ATSM-Cu(II) Biomarker Integrate into the Human Cellular Copper Cycle?
por: Walke, Gulshan R., et al.
Publicado: (2019)

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer’s disease
por: Belaya, Irina, et al.
Publicado: (2020)

Alzheimer’s Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes
por: Gynther, Mikko, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_bar6fbnb5e5qijjhhm64uphvj7