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Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues

Pulmonary hypertension (PH) is a common and severe complication of heart failure (HF). Consequently, HF is the leading cause of PH. For many years, specialists have attempted to better understand the pathophysiology of PH in HF, to define its prevalence and its impact on prognosis in order to improv...

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Autores principales: Berthelot, Emmanuelle, Bauer, Fabrice, Eicher, Jean‐Christophe, Flécher, Erwan, Gellen, Barnabas, Guihaire, Julien, Guijarro, Damien, Roul, Gérald, Salvat, Muriel, Tribouilloy, Christophe, Zores, Florian, Lamblin, Nicolas, de Groote, Pascal, Damy, Thibaud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165943/
https://www.ncbi.nlm.nih.gov/pubmed/30030912
http://dx.doi.org/10.1002/ehf2.12316
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author Berthelot, Emmanuelle
Bauer, Fabrice
Eicher, Jean‐Christophe
Flécher, Erwan
Gellen, Barnabas
Guihaire, Julien
Guijarro, Damien
Roul, Gérald
Salvat, Muriel
Tribouilloy, Christophe
Zores, Florian
Lamblin, Nicolas
de Groote, Pascal
Damy, Thibaud
author_facet Berthelot, Emmanuelle
Bauer, Fabrice
Eicher, Jean‐Christophe
Flécher, Erwan
Gellen, Barnabas
Guihaire, Julien
Guijarro, Damien
Roul, Gérald
Salvat, Muriel
Tribouilloy, Christophe
Zores, Florian
Lamblin, Nicolas
de Groote, Pascal
Damy, Thibaud
author_sort Berthelot, Emmanuelle
collection PubMed
description Pulmonary hypertension (PH) is a common and severe complication of heart failure (HF). Consequently, HF is the leading cause of PH. For many years, specialists have attempted to better understand the pathophysiology of PH in HF, to define its prevalence and its impact on prognosis in order to improve the therapeutic management of these patients. Nowadays, despite the recent guidelines published on the subject, several points remain unclear or debated, and until now, no study has demonstrated the efficacy of any treatment. The aim of this review is to report the evolution of the concepts on post‐capillary PH (diagnosis, prevalence, prognosis, and therapeutics). The main issues are raised, focusing especially on the link between structural alterations and haemodynamic abnormalities, to discuss the possible reasons for treatment failures and future potential targets.
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spelling pubmed-61659432018-10-04 Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues Berthelot, Emmanuelle Bauer, Fabrice Eicher, Jean‐Christophe Flécher, Erwan Gellen, Barnabas Guihaire, Julien Guijarro, Damien Roul, Gérald Salvat, Muriel Tribouilloy, Christophe Zores, Florian Lamblin, Nicolas de Groote, Pascal Damy, Thibaud ESC Heart Fail Reviews Pulmonary hypertension (PH) is a common and severe complication of heart failure (HF). Consequently, HF is the leading cause of PH. For many years, specialists have attempted to better understand the pathophysiology of PH in HF, to define its prevalence and its impact on prognosis in order to improve the therapeutic management of these patients. Nowadays, despite the recent guidelines published on the subject, several points remain unclear or debated, and until now, no study has demonstrated the efficacy of any treatment. The aim of this review is to report the evolution of the concepts on post‐capillary PH (diagnosis, prevalence, prognosis, and therapeutics). The main issues are raised, focusing especially on the link between structural alterations and haemodynamic abnormalities, to discuss the possible reasons for treatment failures and future potential targets. John Wiley and Sons Inc. 2018-07-20 /pmc/articles/PMC6165943/ /pubmed/30030912 http://dx.doi.org/10.1002/ehf2.12316 Text en © 2018 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Reviews
Berthelot, Emmanuelle
Bauer, Fabrice
Eicher, Jean‐Christophe
Flécher, Erwan
Gellen, Barnabas
Guihaire, Julien
Guijarro, Damien
Roul, Gérald
Salvat, Muriel
Tribouilloy, Christophe
Zores, Florian
Lamblin, Nicolas
de Groote, Pascal
Damy, Thibaud
Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues
title Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues
title_full Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues
title_fullStr Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues
title_full_unstemmed Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues
title_short Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues
title_sort pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165943/
https://www.ncbi.nlm.nih.gov/pubmed/30030912
http://dx.doi.org/10.1002/ehf2.12316
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