Cargando…
Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues
Pulmonary hypertension (PH) is a common and severe complication of heart failure (HF). Consequently, HF is the leading cause of PH. For many years, specialists have attempted to better understand the pathophysiology of PH in HF, to define its prevalence and its impact on prognosis in order to improv...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165943/ https://www.ncbi.nlm.nih.gov/pubmed/30030912 http://dx.doi.org/10.1002/ehf2.12316 |
_version_ | 1783359938564718592 |
---|---|
author | Berthelot, Emmanuelle Bauer, Fabrice Eicher, Jean‐Christophe Flécher, Erwan Gellen, Barnabas Guihaire, Julien Guijarro, Damien Roul, Gérald Salvat, Muriel Tribouilloy, Christophe Zores, Florian Lamblin, Nicolas de Groote, Pascal Damy, Thibaud |
author_facet | Berthelot, Emmanuelle Bauer, Fabrice Eicher, Jean‐Christophe Flécher, Erwan Gellen, Barnabas Guihaire, Julien Guijarro, Damien Roul, Gérald Salvat, Muriel Tribouilloy, Christophe Zores, Florian Lamblin, Nicolas de Groote, Pascal Damy, Thibaud |
author_sort | Berthelot, Emmanuelle |
collection | PubMed |
description | Pulmonary hypertension (PH) is a common and severe complication of heart failure (HF). Consequently, HF is the leading cause of PH. For many years, specialists have attempted to better understand the pathophysiology of PH in HF, to define its prevalence and its impact on prognosis in order to improve the therapeutic management of these patients. Nowadays, despite the recent guidelines published on the subject, several points remain unclear or debated, and until now, no study has demonstrated the efficacy of any treatment. The aim of this review is to report the evolution of the concepts on post‐capillary PH (diagnosis, prevalence, prognosis, and therapeutics). The main issues are raised, focusing especially on the link between structural alterations and haemodynamic abnormalities, to discuss the possible reasons for treatment failures and future potential targets. |
format | Online Article Text |
id | pubmed-6165943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61659432018-10-04 Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues Berthelot, Emmanuelle Bauer, Fabrice Eicher, Jean‐Christophe Flécher, Erwan Gellen, Barnabas Guihaire, Julien Guijarro, Damien Roul, Gérald Salvat, Muriel Tribouilloy, Christophe Zores, Florian Lamblin, Nicolas de Groote, Pascal Damy, Thibaud ESC Heart Fail Reviews Pulmonary hypertension (PH) is a common and severe complication of heart failure (HF). Consequently, HF is the leading cause of PH. For many years, specialists have attempted to better understand the pathophysiology of PH in HF, to define its prevalence and its impact on prognosis in order to improve the therapeutic management of these patients. Nowadays, despite the recent guidelines published on the subject, several points remain unclear or debated, and until now, no study has demonstrated the efficacy of any treatment. The aim of this review is to report the evolution of the concepts on post‐capillary PH (diagnosis, prevalence, prognosis, and therapeutics). The main issues are raised, focusing especially on the link between structural alterations and haemodynamic abnormalities, to discuss the possible reasons for treatment failures and future potential targets. John Wiley and Sons Inc. 2018-07-20 /pmc/articles/PMC6165943/ /pubmed/30030912 http://dx.doi.org/10.1002/ehf2.12316 Text en © 2018 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Reviews Berthelot, Emmanuelle Bauer, Fabrice Eicher, Jean‐Christophe Flécher, Erwan Gellen, Barnabas Guihaire, Julien Guijarro, Damien Roul, Gérald Salvat, Muriel Tribouilloy, Christophe Zores, Florian Lamblin, Nicolas de Groote, Pascal Damy, Thibaud Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues |
title | Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues |
title_full | Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues |
title_fullStr | Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues |
title_full_unstemmed | Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues |
title_short | Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues |
title_sort | pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165943/ https://www.ncbi.nlm.nih.gov/pubmed/30030912 http://dx.doi.org/10.1002/ehf2.12316 |
work_keys_str_mv | AT berthelotemmanuelle pulmonaryhypertensioninchronicheartfailuredefinitionsadvancesandunansweredissues AT bauerfabrice pulmonaryhypertensioninchronicheartfailuredefinitionsadvancesandunansweredissues AT eicherjeanchristophe pulmonaryhypertensioninchronicheartfailuredefinitionsadvancesandunansweredissues AT flechererwan pulmonaryhypertensioninchronicheartfailuredefinitionsadvancesandunansweredissues AT gellenbarnabas pulmonaryhypertensioninchronicheartfailuredefinitionsadvancesandunansweredissues AT guihairejulien pulmonaryhypertensioninchronicheartfailuredefinitionsadvancesandunansweredissues AT guijarrodamien pulmonaryhypertensioninchronicheartfailuredefinitionsadvancesandunansweredissues AT roulgerald pulmonaryhypertensioninchronicheartfailuredefinitionsadvancesandunansweredissues AT salvatmuriel pulmonaryhypertensioninchronicheartfailuredefinitionsadvancesandunansweredissues AT tribouilloychristophe pulmonaryhypertensioninchronicheartfailuredefinitionsadvancesandunansweredissues AT zoresflorian pulmonaryhypertensioninchronicheartfailuredefinitionsadvancesandunansweredissues AT lamblinnicolas pulmonaryhypertensioninchronicheartfailuredefinitionsadvancesandunansweredissues AT degrootepascal pulmonaryhypertensioninchronicheartfailuredefinitionsadvancesandunansweredissues AT damythibaud pulmonaryhypertensioninchronicheartfailuredefinitionsadvancesandunansweredissues |