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Protein Kinase C Activity and Delayed Recovery of Sleep-Wake Cycle in Mouse Model of Bipolar Disorder

OBJECTIVE: Previous studies reported the delayed recovery group after circadian rhythm disruption in mice showed higher quinpiroleinduced locomotor activity. This study aimed to compare not only Protein Kinase C (PKC) activities in frontal, striatal, hippocampus and cerebellum, but also relative PKC...

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Autores principales: Moon, Eunsoo, Choe, Byeong-Moo, Park, Je-Min, Chung, Young In, Lee, Byung Dae, Park, Jae-Hong, Lee, Young Min, Jeong, Hee Jeong, Cheon, YongJun, Choi, Yoonmi, Park, Jeonghyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166033/
https://www.ncbi.nlm.nih.gov/pubmed/30235919
http://dx.doi.org/10.30773/pi.2018.05.23
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author Moon, Eunsoo
Choe, Byeong-Moo
Park, Je-Min
Chung, Young In
Lee, Byung Dae
Park, Jae-Hong
Lee, Young Min
Jeong, Hee Jeong
Cheon, YongJun
Choi, Yoonmi
Park, Jeonghyun
author_facet Moon, Eunsoo
Choe, Byeong-Moo
Park, Je-Min
Chung, Young In
Lee, Byung Dae
Park, Jae-Hong
Lee, Young Min
Jeong, Hee Jeong
Cheon, YongJun
Choi, Yoonmi
Park, Jeonghyun
author_sort Moon, Eunsoo
collection PubMed
description OBJECTIVE: Previous studies reported the delayed recovery group after circadian rhythm disruption in mice showed higher quinpiroleinduced locomotor activity. This study aimed to compare not only Protein Kinase C (PKC) activities in frontal, striatal, hippocampus and cerebellum, but also relative PKC activity ratios among brain regions according to recovery of circadian rhythm. METHODS: The circadian rhythm disruption protocol was applied to eight-week-old twenty male Institute Cancer Research mice. The circadian rhythm recovery patterns were collected through motor activities measured by Mlog system. Depressive and manic proneness were examined by forced swim test and quinpirole-induced open field test respectively. Enzyme-linked immunosorbent assay was employed to measure PKC activities. RESULTS: The delayed recovery group presented greater locomotor activities than the early recovery group (p=0.033). The delayed recovery group had significantly lower frontal PKC activity than the other (p=0.041). The former showed lower frontal/cerebellar PKC activity ratio (p=0.047) but higher striatal/frontal (p=0.038) and hippocampal/frontal (p=0.007) PKC activities ratios than the latter. CONCLUSION: These findings support potential mechanism of delayed recovery after circadian disruption in bipolar animal model could be an alteration of relative PKC activities among mood regulation related brain regions. It is required to investigate the PKC downstream signaling related to the delayed recovery pattern.
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spelling pubmed-61660332018-10-11 Protein Kinase C Activity and Delayed Recovery of Sleep-Wake Cycle in Mouse Model of Bipolar Disorder Moon, Eunsoo Choe, Byeong-Moo Park, Je-Min Chung, Young In Lee, Byung Dae Park, Jae-Hong Lee, Young Min Jeong, Hee Jeong Cheon, YongJun Choi, Yoonmi Park, Jeonghyun Psychiatry Investig Original Article OBJECTIVE: Previous studies reported the delayed recovery group after circadian rhythm disruption in mice showed higher quinpiroleinduced locomotor activity. This study aimed to compare not only Protein Kinase C (PKC) activities in frontal, striatal, hippocampus and cerebellum, but also relative PKC activity ratios among brain regions according to recovery of circadian rhythm. METHODS: The circadian rhythm disruption protocol was applied to eight-week-old twenty male Institute Cancer Research mice. The circadian rhythm recovery patterns were collected through motor activities measured by Mlog system. Depressive and manic proneness were examined by forced swim test and quinpirole-induced open field test respectively. Enzyme-linked immunosorbent assay was employed to measure PKC activities. RESULTS: The delayed recovery group presented greater locomotor activities than the early recovery group (p=0.033). The delayed recovery group had significantly lower frontal PKC activity than the other (p=0.041). The former showed lower frontal/cerebellar PKC activity ratio (p=0.047) but higher striatal/frontal (p=0.038) and hippocampal/frontal (p=0.007) PKC activities ratios than the latter. CONCLUSION: These findings support potential mechanism of delayed recovery after circadian disruption in bipolar animal model could be an alteration of relative PKC activities among mood regulation related brain regions. It is required to investigate the PKC downstream signaling related to the delayed recovery pattern. Korean Neuropsychiatric Association 2018-09 2018-09-17 /pmc/articles/PMC6166033/ /pubmed/30235919 http://dx.doi.org/10.30773/pi.2018.05.23 Text en Copyright © 2018 Korean Neuropsychiatric Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Moon, Eunsoo
Choe, Byeong-Moo
Park, Je-Min
Chung, Young In
Lee, Byung Dae
Park, Jae-Hong
Lee, Young Min
Jeong, Hee Jeong
Cheon, YongJun
Choi, Yoonmi
Park, Jeonghyun
Protein Kinase C Activity and Delayed Recovery of Sleep-Wake Cycle in Mouse Model of Bipolar Disorder
title Protein Kinase C Activity and Delayed Recovery of Sleep-Wake Cycle in Mouse Model of Bipolar Disorder
title_full Protein Kinase C Activity and Delayed Recovery of Sleep-Wake Cycle in Mouse Model of Bipolar Disorder
title_fullStr Protein Kinase C Activity and Delayed Recovery of Sleep-Wake Cycle in Mouse Model of Bipolar Disorder
title_full_unstemmed Protein Kinase C Activity and Delayed Recovery of Sleep-Wake Cycle in Mouse Model of Bipolar Disorder
title_short Protein Kinase C Activity and Delayed Recovery of Sleep-Wake Cycle in Mouse Model of Bipolar Disorder
title_sort protein kinase c activity and delayed recovery of sleep-wake cycle in mouse model of bipolar disorder
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166033/
https://www.ncbi.nlm.nih.gov/pubmed/30235919
http://dx.doi.org/10.30773/pi.2018.05.23
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